Podcast
Questions and Answers
Which gene is responsible for regulating the ectopic expression of tissue-specific antigens in the thymus?
Which gene is responsible for regulating the ectopic expression of tissue-specific antigens in the thymus?
- FoxP3 gene
- MHC gene
- AIRE gene (correct)
- HLA gene
What is the key feature of IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-Linked) syndrome?
What is the key feature of IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-Linked) syndrome?
- Inflammatory bowel disease (correct)
- Autoimmune adrenal disease
- Cleft palate
- Candidiasis
What is the main trigger for coeliac disease in predisposed individuals?
What is the main trigger for coeliac disease in predisposed individuals?
- Antibodies
- Gluten (correct)
- Autoantigens
- Viral infection
What is the mechanism of tissue damage in coeliac disease?
What is the mechanism of tissue damage in coeliac disease?
Which of the following best describes autoimmunity?
Which of the following best describes autoimmunity?
What is the purpose of negative selection in the immune system?
What is the purpose of negative selection in the immune system?
What are some mechanisms of peripheral tolerance?
What are some mechanisms of peripheral tolerance?
Which of the following autoimmune diseases is classified as multi-system?
Which of the following autoimmune diseases is classified as multi-system?
Which of the following autoimmune diseases is believed to have a possible link with Coxsackie Virus?
Which of the following autoimmune diseases is believed to have a possible link with Coxsackie Virus?
What is the major defined genetic risk factor for type 1 diabetes?
What is the major defined genetic risk factor for type 1 diabetes?
Which viral infection is thought to be a major requirement for the subsequent development of multiple sclerosis?
Which viral infection is thought to be a major requirement for the subsequent development of multiple sclerosis?
Which therapy has been found to be effective for relapsing-remitting multiple sclerosis?
Which therapy has been found to be effective for relapsing-remitting multiple sclerosis?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
Which immune cells are responsible for damaging tissue directly in autoimmune diseases?
Which immune cells are responsible for damaging tissue directly in autoimmune diseases?
In autoimmune hypothyroidism (Hashimoto's thyroiditis), which immune cells infiltrate the thyroid and contribute to its autoimmune destruction?
In autoimmune hypothyroidism (Hashimoto's thyroiditis), which immune cells infiltrate the thyroid and contribute to its autoimmune destruction?
According to Charles Janeway, what is the most accurate way to consider autoimmune responses?
According to Charles Janeway, what is the most accurate way to consider autoimmune responses?
Which method is used to detect antibodies in blood by adding a detection antibody labeled with a fluorescent marker?
Which method is used to detect antibodies in blood by adding a detection antibody labeled with a fluorescent marker?
What is the target antigen in bullous skin disease pemphigus?
What is the target antigen in bullous skin disease pemphigus?
Which disease is associated with antibodies binding to the endomysium of smooth muscle fibers?
Which disease is associated with antibodies binding to the endomysium of smooth muscle fibers?
Which method is used to detect antibodies in blood by incubating patient serum containing (or not) relevant antibodies with a detection antibody labeled with a fluorescent marker?
Which method is used to detect antibodies in blood by incubating patient serum containing (or not) relevant antibodies with a detection antibody labeled with a fluorescent marker?
Which of the following is a key aim of the lectures on autoimmune diseases?
Which of the following is a key aim of the lectures on autoimmune diseases?
What is the term used to describe immune responses to self-antigens?
What is the term used to describe immune responses to self-antigens?
Which of the following is NOT a learning outcome mentioned in the text?
Which of the following is NOT a learning outcome mentioned in the text?
What are the types of hypersensitivity mentioned in the lectures on autoimmune diseases?
What are the types of hypersensitivity mentioned in the lectures on autoimmune diseases?
Which of the following is the target antigen found in modern immunoassays for coeliac disease?
Which of the following is the target antigen found in modern immunoassays for coeliac disease?
What is the role of INTRINSIC FACTOR in the absorption of Vitamin B12?
What is the role of INTRINSIC FACTOR in the absorption of Vitamin B12?
What is the consequence of autoimmune destruction of the gastric parietal cells in pernicious anaemia?
What is the consequence of autoimmune destruction of the gastric parietal cells in pernicious anaemia?
Which of the following is NOT a possible manifestation of Vitamin B12 depletion in pernicious anaemia?
Which of the following is NOT a possible manifestation of Vitamin B12 depletion in pernicious anaemia?
What is the purpose of plasmapharesis in antibody-mediated diseases?
What is the purpose of plasmapharesis in antibody-mediated diseases?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
Which field of study overlaps with transplantation work and is complex to understand?
Which field of study overlaps with transplantation work and is complex to understand?
What is the term used to describe the immune system's ability to tolerate self-antigens?
What is the term used to describe the immune system's ability to tolerate self-antigens?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
What is the main trigger for coeliac disease in predisposed individuals?
What is the main trigger for coeliac disease in predisposed individuals?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
What is the most common cause of underactive thyroid in industrialized countries?
What is the most common cause of underactive thyroid in industrialized countries?
Which immune cells infiltrate the thyroid in autoimmune hypothyroidism?
Which immune cells infiltrate the thyroid in autoimmune hypothyroidism?
What is the major difference between studying antibodies and studying auto reactive T cells?
What is the major difference between studying antibodies and studying auto reactive T cells?
Which of the following is NOT a characteristic of autoimmune diseases?
Which of the following is NOT a characteristic of autoimmune diseases?
What is the purpose of positive selection in the immune system?
What is the purpose of positive selection in the immune system?
What is the role of somatic recombination in the generation of adaptive immune receptors?
What is the role of somatic recombination in the generation of adaptive immune receptors?
What is the main difference between autoimmunity and autoimmune disease?
What is the main difference between autoimmunity and autoimmune disease?
Which of the following is a characteristic feature of autoimmune haemolytic anaemia?
Which of the following is a characteristic feature of autoimmune haemolytic anaemia?
What is the main cause of visual symptoms in Graves Disease?
What is the main cause of visual symptoms in Graves Disease?
Which of the following is a common symptom of autoimmune thrombocytopenia?
Which of the following is a common symptom of autoimmune thrombocytopenia?
What is the key feature of plasmapheresis in the treatment of antibody-mediated diseases?
What is the key feature of plasmapheresis in the treatment of antibody-mediated diseases?
Which autoimmune disease is characterized by an antibody that activates the thyroid follicles to produce excessive thyroid hormones, leading to symptoms such as weight loss, rapid heartbeat, and anxiety?
Which autoimmune disease is characterized by an antibody that activates the thyroid follicles to produce excessive thyroid hormones, leading to symptoms such as weight loss, rapid heartbeat, and anxiety?
In which autoimmune disease do antibodies directed against the acetylcholine receptor block the transmission of signals to the muscle, causing muscle weakness and fatigue?
In which autoimmune disease do antibodies directed against the acetylcholine receptor block the transmission of signals to the muscle, causing muscle weakness and fatigue?
Which autoimmune disease is associated with an antibody that activates the muscle, causing the release of histamine and resulting in itchy rash and hives?
Which autoimmune disease is associated with an antibody that activates the muscle, causing the release of histamine and resulting in itchy rash and hives?
Which type of autoimmunity is characterized by the presence of pathogenic autoantibodies that directly cause the disease?
Which type of autoimmunity is characterized by the presence of pathogenic autoantibodies that directly cause the disease?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
Which type of hypersensitivity is associated with tissue damage directly mediated by T cell-dependent mechanisms?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
Which of the following is NOT a possible manifestation of Vitamin B12 depletion in pernicious anaemia?
Which of the following is NOT a possible manifestation of Vitamin B12 depletion in pernicious anaemia?
What is the role of INTRINSIC FACTOR in the absorption of Vitamin B12?
What is the role of INTRINSIC FACTOR in the absorption of Vitamin B12?
According to Charles Janeway, what is the most accurate way to consider autoimmune responses?
According to Charles Janeway, what is the most accurate way to consider autoimmune responses?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
What is the main reason for treating the consequences of autoimmune diseases instead of the immunology itself?
What are some key components required for autoimmune responses?
What are some key components required for autoimmune responses?
Why is it a mistake to think of one part of the immune system working in isolation?
Why is it a mistake to think of one part of the immune system working in isolation?
Which autoimmune diseases are mentioned as examples of more complex diseases?
Which autoimmune diseases are mentioned as examples of more complex diseases?
What is the consequence of autoimmune destruction of the gastric parietal cells in pernicious anaemia?
What is the consequence of autoimmune destruction of the gastric parietal cells in pernicious anaemia?
