Test Your Knowledge on Cerebral Perfusion Pressure and Blood Flow in Neurology
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Questions and Answers

Which of the following is true regarding cerebral autoregulation?

  • Cerebral autoregulation is not affected by changes in mean arterial pressure (MAP).
  • Cerebral autoregulation is primarily controlled by changes in intracranial pressure (ICP).
  • Cerebral autoregulation is only effective in maintaining a consistent CBF of 50 mL/100 g/min in healthy brains.
  • Cerebral autoregulation is believed to be intact between a MAP of 60 to 160 mmHg. (correct)

What happens to cerebral blood flow (CBF) when CPP decreases below the lower limit of autoregulation (LLA)?

  • CBF becomes pressure-dependent, and maximal cerebral vasodilation occurs. (correct)
  • CBF increases in response to decreased CPP.
  • CBF remains constant at 50 mL/100 g/min.
  • CBF decreases proportionally to the decrease in CPP.

What can happen when CPP exceeds the upper limit of autoregulation?

  • Cerebral autoregulation becomes more effective at maintaining a consistent CBF.
  • Cerebral vessels are maximally vasoconstricted, and increased perfusion pressure can cause disruptions such as blood-brain barrier (BBB) disruption, cerebral edema, or cerebral hemorrhage. (correct)
  • Cerebral vessels dilate, leading to increased CBF and improved brain function.
  • CVR decreases, leading to decreased CBF and potential cerebral ischemia.

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