12 Questions
What enables a cell to judge the strength of the response?
Graded signaling
Which signaling property is crucial for producing varying patterns of gene expression?
Time
What is the role of adaptors in cellular signaling?
Bridge signaling proteins to create a hub
How does Ras become active in cellular signaling pathways?
Binding to GDP and then converting GDP to GTP
What mediates the assembly of signaling complexes in cells?
Adaptor proteins
Which property of signaling proteins is important for their interaction with each other?
Space proximity
What is the role of G-protein ACTIVATING or EXCHANGE (GAP and GEF) factors in signaling?
Dictate the degree of signaling at the cell membrane
What is the function of ITAM (Immunoreceptor Tyrosine Activation Motif) in signaling?
Providing a site for kinase phosphorylation of tyrosine residues
What is the main role of ZAP-70 in the signaling process described in the text?
Phosphorylating LAT and SLP-76 to initiate downstream signaling modules
How does concentration of receptor-associated Lck increase in the signaling cascade?
Recruiting co-receptors to the TCR/BCR
What is the role of Csk in the signaling cascade described in the text?
Phosphorylates Lck to promote 'off' conformational configuration
Which statement accurately describes the role of second messengers in signal transduction?
Second messengers function downstream of receptor interactions
Test your knowledge on cell signaling properties such as increased cell size, gene expression changes, metabolism changes, and cell proliferation probability. Learn about how graded signaling enables cells to judge response strength and how antigen receptor signaling can vary gene expression patterns.
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