Hormones and Cell Signaling Quiz
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Questions and Answers

What is the approximate chance of a thyroid nodule identified on PET scanning being malignant?

  • 10%
  • 33% (correct)
  • 50%
  • 25%
  • Which imaging technique should be performed in an individual with a low serum TSH and a nodular thyroid to confirm the presence of an autonomously functioning nodule?

  • MRI
  • CT scan
  • Thyroid scintigraphy with 99mtechnetium (correct)
  • Ultrasound scan
  • What should be measured in all patients with a goitre or solitary thyroid nodule?

  • Serum T3 only
  • Serum T4 only
  • Serum T3, T4 and TSH (correct)
  • Serum TSH only
  • In which location are thyroglossal duct cysts classically located?

    <p>Midline</p> Signup and view all the answers

    What investigation should be performed urgently if there is any doubt as to the aetiology of an anterior neck swelling?

    <p>Ultrasound scan</p> Signup and view all the answers

    When is further evaluation not necessary for a nodular thyroid?

    <p>If it is autonomously functioning ('hot')</p> Signup and view all the answers

    What should lead to investigations in patients with biochemical thyrotoxicosis or hypothyroidism?

    <p>$Biochemical$ thyrotoxicosis or hypothyroidism</p> Signup and view all the answers

    Where are many receptors located?

    <p>On the cell surface</p> Signup and view all the answers

    What is the preferred treatment for patients with distant metastases of papillary and follicular thyroid cancer?

    <p>131I therapy</p> Signup and view all the answers

    Which type of hormones bind to specific intracellular receptors?

    <p>Steroids</p> Signup and view all the answers

    Which type of thyroid cancer has shown an increasing incidence since 1990?

    <p>Papillary carcinoma</p> Signup and view all the answers

    In which way do some hormones act to affect adjacent cells?

    <p>Paracrinely</p> Signup and view all the answers

    What are some adverse prognostic factors for papillary and follicular thyroid cancer?

    <p>Female sex</p> Signup and view all the answers

    What is the enzyme responsible for the production of estrogens from adrenal androgens in adipose tissue?

    <p>Aromatase</p> Signup and view all the answers

    In which type of multiple endocrine neoplasia (MEN) can medullary carcinoma occur in childhood?

    <p>Type 2a</p> Signup and view all the answers

    Which model of endocrine function involves hormones released into the circulation and acting at distant sites?

    <p>Classical model</p> Signup and view all the answers

    What is the most common outcome for patients with papillary and follicular thyroid cancer?

    <p>Cure with appropriate treatment</p> Signup and view all the answers

    What is often called 'primary' disease when arising within the gland?

    <p>Primary pathology</p> Signup and view all the answers

    Which therapy can be effective in treating those with distant metastases of thyroid cancer?

    <p>$131I$ therapy</p> Signup and view all the answers

    What is often called 'secondary' disease when there is abnormal stimulation of the gland?

    <p>'Secondary' pathology</p> Signup and view all the answers

    What is the rate per 100,000 persons for medullary carcinoma in multiple endocrine neoplasia (MEN) type 2b?

    <p>$666$</p> Signup and view all the answers

    What has been the trend in death rates of thyroid cancer since 1992?

    <p>$Increase$</p> Signup and view all the answers

    In which decade was the rate of new cases of thyroid cancer highest?

    <p>$2010s$</p> Signup and view all the answers

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