Tablet Compression Process

<p>Concerns about the safety and environmental impact of organic solvents. (B)</p> Signup and view all the answers

<p>Continuously providing hot air. (B)</p> Signup and view all the answers

<p>Possession of a strong and distinctive odor. (A)</p> Signup and view all the answers

<p>The desired site of drug release and release rate. (B)</p> Signup and view all the answers

<p>Organic solvents for water-insoluble polymers or water for water-soluble polymers. (C)</p> Signup and view all the answers

<p>To remove excess powder and ensure accurate powder weight. (D)</p> Signup and view all the answers

<p>Electrostatic repulsion (D)</p> Signup and view all the answers

<p>They ensure consistency and accuracy in the amount of powder fed into the die. (B)</p> Signup and view all the answers

<p>Air between the granules (D)</p> Signup and view all the answers

<p>The adjustable height of the punches (A)</p> Signup and view all the answers

<p>Ejection (C)</p> Signup and view all the answers

<p>To push the tablet up to the surface of the die table. (A)</p> Signup and view all the answers

<p>Precise recommended dosage. (D)</p> Signup and view all the answers

<p>To check for variations and maintain specifications. (B)</p> Signup and view all the answers

<p>To increase the weight of the tablet. (A)</p> Signup and view all the answers

<p>To prevent moisture penetration into the tablet core (D)</p> Signup and view all the answers

<p>Pharmaceutical Shellac, CAP and PAP (B)</p> Signup and view all the answers

<p>By passing air over the tumbling pans. (C)</p> Signup and view all the answers

<p>Smooth, rounded and polished surfaces. (B)</p> Signup and view all the answers

<p>To round off the tablet edges (A)</p> Signup and view all the answers

<p>To prevent tablets from sticking together during drying (B)</p> Signup and view all the answers

<p>To protect the drug from the gastric environment. (A)</p> Signup and view all the answers

<p>To ensure a uniform application of color (C)</p> Signup and view all the answers

<p>Spray coating (B)</p> Signup and view all the answers

<p>To create a glossy finish (B)</p> Signup and view all the answers

<p>Film coating. (A)</p> Signup and view all the answers

<p>Applying a special edible ink (B)</p> Signup and view all the answers

<p>Variations in the tablet. (A)</p> Signup and view all the answers

<p>Film coating is less time-consuming (C)</p> Signup and view all the answers

A solid dosage form made by compressing powdered medication.

The transfer of powdered medication into the tablet compression machine.

The process of ensuring a consistent amount of powder is fed into the tablet die.

The stage where the powder is compressed into a tablet using pressure.

The stage where the compressed tablet is ejected from the die.

The interlocking of particles, phase transition at contact points, and intermolecular forces that hold the tablet together.

The process of achieving the correct dosage, cleanliness, ease of handling, and minimal waste.

Substances added to the powder to improve tablet properties like flowability, binding, and disintegration.

When the addition of excipients is inaccurate or errors occur during the granulation process of tablet manufacturing.

The process of applying a thin layer of edible material to the surface of a tablet. This is an additional step in tablet production that aims to improve the tablet's properties.

To mask the bitter taste, odor or color of the drug, protect the drug from the stomach's acidic environment, control release of drug from the tablet, and improve the overall appearance of the tablet for better patient acceptance.

A traditional coating method that involves several steps to build a thick layer of sugar over the tablet, making it smooth and shiny.

A modern coating method that uses a thin film of polymers to create a protective barrier over the tablet. It's quicker and more efficient compared to sugar coating.

A specialized coating method where a compressed layer of material is applied directly to the core of the tablet, often using a specific press.

A coating method specifically designed to protect drugs in the stomach and release them in the intestines.

The process of applying coating material to the tablet surface, ensuring uniformity and avoiding cracks.

The first step in sugar coating, sealing tablets involves applying a waterproof layer to prevent water penetration and maintain stability.

Aqueous sugar coatings can be affected by water, potentially leading to instability and premature disintegration. Sealing the tablet core with a water-resistant layer prevents this.

This step involves applying multiple layers of water-insoluble polymers such as Shellac or cellulose acetate phthalate to the tablet core.

A process that adds a significant amount of sugar coating to the tablet core, usually increasing the tablet's weight by 50-100%. This helps to round off the tablet's edges.

To achieve a smooth surface for subsequent color application, the rough surface created after the sub-coating stage is smoothed out using a thick sucrose syrup coating.

Adding a thin layer of sucrose containing water-soluble dyes or water-insoluble pigments to the smooth, subcoated tablet.

This final step involves applying waxes such as beeswax or carnuba wax to achieve a glossy finish for the sugar-coated tablet.

Printing is used to identify different tablets by manufacturer logo, product name, dosage strength, or a code, using edible inks.

Polymers used for coatings that dissolve in the stomach, allowing the drug to be released quickly.

Polymers used for coatings that dissolve in the intestines, allowing the drug to be released slowly.

A liquid used to dissolve polymers for coating tablets. Common examples include water and organic solvents.

A coating process where a liquid solution of polymers, pigments, and excipients is dissolved in an organic solvent or water and then sprayed onto tablets in a pan, followed by drying with hot air.

Coatings made using organic solvents to dissolve polymers. Examples include acetone, ethanol, and methanol.

Coatings made using water as the solvent to dissolve polymers. It's preferred over organic coatings due to its safety and environmental friendliness.

The shift from organic solvents to water as the preferred solvent in film coating. This makes the process more economical, but may require investment in upgrading coating facilities.