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Which enzyme is involved in the synthesis of acetylcholine?
What is the term used for drugs that mimic the action of acetylcholine in the autonomic nervous system?
Which type of receptor is always stimulatory and is involved in the release of acetylcholine?
Which receptor subtype is responsible for the excitatory negative chronotropic effect in the cardiovascular system?
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Which receptor subtype is responsible for bronchoconstriction in the respiratory tract?
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Which receptor subtype is responsible for bladder contraction in the urinary tract?
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Which receptor subtype is responsible for miosis in the eye?
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Which of the following is a therapeutic application of Pilocarpine?
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What is the most important and only modifiable risk factor for glaucoma?
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Which of the following is a potential adverse effect of Pilocarpine?
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Which of the following drugs is hydrolyzed by acetylcholinesterases at a relatively slow rate?
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What is the mechanism of action of Pilocarpine when applied locally to the cornea?
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Which drug has both muscarinic as well as nicotinic actions?
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Which drug is structurally related to acetylcholine, in which the acetate is replaced by carbamate?
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Which drug is used for urologic treatment and directly stimulates muscarinic receptors in smooth musculature of the bladder and gastrointestinal tract?
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Which enzyme is involved in the synthesis of acetylcholine?
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What is the term used for drugs that mimic the action of acetylcholine in the autonomic nervous system?
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What is the mechanism of action of Pilocarpine when applied locally to the cornea?
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Which of the following is a therapeutic use of methacholine?
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Which of the following drugs is rarely used therapeutically due to its high potency and non-selectivity of receptors?
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Which receptor subtype is responsible for vasodilation in the cardiovascular system?
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Which drug is used for the treatment of neurogenic urinary retention and postoperative atony?
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Which drug is an irreversible anticholinesterase that phosphorylates acetylcholinesterase, leading to permanent enzyme inactivation?
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Which drug is used topically in the eye to produce miosis and spasm of accommodation, and is also used to treat glaucoma?
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Which drug is an indirect-acting cholinergic agonist that enhances cognitive function in patients with Alzheimer's Disease?
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Which drug is a K+ channel antagonist that prolongs excitability and slows down repolarization, leading to increased VCa2+ activation?
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Which of the following is a contraindication for the use of choline esters?
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What is the therapeutic application of Pilocarpine in patients with Sjogren's syndrome?
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What is the primary effect of acetylcholinesterase (AChE) inhibitors?
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Which enzyme is responsible for hydrolyzing acetylcholine at cholinergic synapses?
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Which organophosphate is more dangerous to humans and livestock compared to malathion?
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What is the main purpose of pralidoxime in reactivating acetylcholinesterase?
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What is the limitation of using pralidoxime as a reactivator for acetylcholinesterase?
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Which of the following AChE inhibitors is reversible and forms a covalent bond with the enzyme?
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Which of the following AChE inhibitors is irreversible and has an extremely stable phosphorus-enzyme bond?
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Which of the following AChE inhibitors is used as a cholinesterase regenerator and can break the phosphorus-enzyme bond?
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Which of the following effects can be produced by anti-AChE agents?
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¿Cuál es el paso limitante de la síntesis de ACh en la neurotransmisión colinérgica?
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¿Qué tipo de receptores se activan directamente por los agonistas colinérgicos?
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¿Cuál de los siguientes fármacos se utiliza en el diagnóstico de la miastenia gravis al aumentar rápidamente la fuerza muscular?
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¿Cuál de los siguientes fármacos se utiliza para revertir los efectos de los bloqueadores neuromusculares no despolarizantes después de la cirugía?
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¿Cuál de los siguientes fármacos se utiliza para el manejo crónico de la miastenia gravis debido a su acción prolongada?
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¿Cuál es el subtipo predominante de receptor colinérgico en el control del músculo liso, las glándulas secretoras y el ojo?
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¿Cuál es el efecto de la acetilcolina (ACh) en el tracto respiratorio?
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¿Cuál es el efecto de la acetilcolina (ACh) en el tracto urinario?
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¿Cuál es el tipo de receptor involucrado en la contracción de la vejiga en el tracto urinario?
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¿Cuál es el factor de riesgo más importante y el único modificable para el glaucoma?
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¿Cuál es el porcentaje de pacientes sin tratamiento que desarrollarán ceguera bilateral?
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¿Qué tipo de colinesterasa se encuentra presente en las sinapsis colinérgicas?
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¿Cuál de los siguientes inhibidores de AChE forma un enlace covalente irreversible con la enzima?
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¿Cuál de los siguientes efectos adversos puede producir la metacolina en el sistema cardiovascular?
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¿Cuál de los siguientes fármacos es un agonista parcial que se utiliza para promover las secreciones glandulares?
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¿Cuál de los siguientes fármacos se utiliza como fármaco de elección en emergencias de disminución de presión intraocular?
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¿Cuál de las siguientes afirmaciones es correcta sobre la pilocarpina?
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¿Cuál de los siguientes receptores muscarínicos está involucrado en la modulación de la transmisión colinérgica en los ganglios autónomos?
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¿Cuál es el efecto observado al inyectar ACh intravenosa?
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¿Qué efecto tiene la atropina en la presión sanguínea y la frecuencia cardíaca cuando se administra junto con ACh?
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¿Cuál es el efecto de los receptores M3 en el endotelio del vaso sanguíneo?
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¿Cuál es el mecanismo de acción de los inhibidores de la acetilcolinesterasa?
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¿Cuál es el efecto más prominente de los agentes anti-AChE en el sistema cardiovascular?
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¿Cuál es la principal diferencia entre los agentes anti-AChE y los agonistas colinomiméticos de acción directa?
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¿Cuál es la función principal de la pralidoxima en la reactivación de la acetilcolinesterasa?
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Which Muscarinic agonist?
Bladder Contraction
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Which Muscarinic agonist? Stimulate secreciones
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Which Muscarinic agonist? Negative chronotropic effect
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Which Muscarinic agonist? Vasodilatacion
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Which Muscarinic agonist? Urine Formation
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Which Muscarinic agonist? Miosis
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Study Notes
Acetylcholine Synthesis and Function
- Choline acetyltransferase is the enzyme involved in the synthesis of acetylcholine.
Cholinergic Agonists
- Cholinomimetics are drugs that mimic the action of acetylcholine in the autonomic nervous system.
- Pilocarpine is a cholinomimetic used to treat glaucoma and dry mouth in patients with Sjogren's syndrome.
Muscarinic Receptors
- M1 receptors are involved in bladder contraction in the urinary tract.
- M2 receptors are responsible for the negative chronotropic effect in the cardiovascular system.
- M3 receptors are responsible for bronchoconstriction in the respiratory tract and vasodilation in the cardiovascular system.
- M4 receptors are involved in miosis in the eye.
Cholinesterase Inhibitors
- Acetylcholinesterase (AChE) is the enzyme responsible for hydrolyzing acetylcholine at cholinergic synapses.
- Neurotoxins like organophosphates can inhibit AChE, leading to accumulation of acetylcholine.
- Pralidoxime is used to reactivate AChE inhibited by organophosphates.
Therapeutic Applications
- Methacholine is used to diagnose myasthenia gravis and to treat urinary retention and postoperative atony.
- Pilocarpine is used to treat glaucoma and dry mouth in patients with Sjogren's syndrome.
- Cholinesterase inhibitors like donepezil are used to treat Alzheimer's disease.
Pharmacology
- Bethanechol is a cholinergic agonist used to stimulate gastrointestinal motility and bladder contraction.
- Carbachol is a cholinergic agonist used to treat glaucoma and induce miosis.
- Neostigmine is a cholinesterase inhibitor used to treat myasthenia gravis and reverse the effects of non-depolarizing neuromuscular blockers.
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Description
Test your knowledge on synthetic compounds and their effects on nicotinic receptors. This quiz explores the affinity of synthetic compounds for specific receptors and their impact on cardiac function.