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Acetylcholine Synthesis and Degradation
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Acetylcholine Synthesis and Degradation

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Questions and Answers

Which enzyme is responsible for synthesizing acetylcholine from choline and acetyl-CoA?

  • Phenylethanolamine N-methyltransferase (PNMT)
  • Monoamine oxidase (MAO)
  • Choline acetyltransferase (ChAT) (correct)
  • Acetylcholinesterase (AChE)
  • What is acetylcholine transported into synaptic vesicles via?

  • VMAT
  • VGLUT
  • VACIT (correct)
  • SERT
  • Which enzyme degrades acetylcholine in the synaptic cleft?

  • Catechol-O-methyltransferase (COMT)
  • Monoamine oxidase (MAO)
  • Acetylcholinesterase (AChE) (correct)
  • Tyrosine hydroxylase (TH)
  • What is the fate of the acetate after acetylcholine is degraded?

    <p>It is recycled by the nerve terminal.</p> Signup and view all the answers

    Where does acetylcholine bind after being released into the synaptic cleft?

    <p>Acetylcholine receptors on the postsynaptic membrane</p> Signup and view all the answers

    Which of the following molecules are recycled back into the presynaptic neuron?

    <p>Choline and acetate</p> Signup and view all the answers

    Study Notes

    Synthesis of Acetylcholine

    • Acetylcholine is synthesized from choline and acetyl coenzyme A (acetyl-CoA) by the enzyme choline acetyltransferase (ChAT).

    Release of Acetylcholine

    • Acetylcholine is released from the presynaptic nerve terminal into the synaptic cleft.
    • Acetylcholine is transported into synaptic vesicles via VACIT.
    • Acetylcholine is released from vesicles into the synaptic cleft by nerve impulse.

    Binding of Acetylcholine

    • Acetylcholine binds to the acetylcholine receptors on the postsynaptic membrane.
    • Acetylcholine binds to receptors on muscle fibers.

    Degradation of Acetylcholine

    • Acetylcholine is degraded by the enzyme acetylcholinesterase (AChE).
    • The products of degradation are choline and acetate.

    Recycling of Products

    • Choline is recycled back into the presynaptic neuron for the synthesis of new acetylcholine.
    • Acetate is recycled by the nerve terminal.

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    Description

    This diagram illustrates the steps involved in the synthesis and degradation of acetylcholine, a neurotransmitter. Learn about the enzymes and processes involved in this biological process.

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