Suppository Preparation Methods

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What is the purpose of the water number in suppository formulations?

To indicate the level of free acids present

To measure the iodine value of the fat

To assess the rancidity potential of the suppository base

To determine the amount of water that can be incorporated in the fat (correct)

Which suppository manufacturing method is best suited when only a few suppositories need to be prepared?

Hand molding (correct)

Pour molding

Automatic molding

Compression molding

What is the primary advantage of compression molding for making suppositories?

It allows for easy incorporation of the drug

It requires less specialized equipment

It is the fastest method of suppository production

It results in a more uniform product (correct)

Which suppository manufacturing method involves pouring the melted base and drug mixture into molds?

Pour molding Signup and view all the answers

Which suppository manufacturing method is considered the most advanced and efficient?

Automatic molding Signup and view all the answers

What is the primary purpose of the triturating step in the hand molding suppository manufacturing method?

To ensure uniform distribution of the drug in the base Signup and view all the answers

What is the most commonly used method for preparing suppositories?

Pour molding Signup and view all the answers

What is the typical output rate of a rotary automatic molding machine for suppositories?

3,500 - 6,000 suppositories per hour Signup and view all the answers

Which type of suppositories can be stored at room temperature without refrigeration?

Polyethylene glycol suppositories Signup and view all the answers

What is an advantage of using disposable plastic molds over conventional metal molds for suppository preparation?

Mold shapes can be changed with less expense using plastic molds Signup and view all the answers

In the mortar and pestle method for suppository preparation, what facilitates the softening of the base?

Preheating the mortar Signup and view all the answers

Which test is mentioned in the text for suppository quality control?

Melting range test Signup and view all the answers

What is the purpose of coating the cavities with polytetrofluoroethylene (Teflone) in the release of suppositories?

To improve the release of the suppository from the mold Signup and view all the answers

What is the main cause of contraction holes formation at the open end of the suppository mold?

Volume contraction of the melted suppository base after cooling Signup and view all the answers

How can the contraction of the suppository mass be eliminated after cooling the mold?

Both a and b Signup and view all the answers

What is the main problem caused by using a low viscosity suppository base?

Sedimentation of suspended particles Signup and view all the answers

How can the issues caused by using a low viscosity suppository base be overcome?

Both a and b Signup and view all the answers

Which of the following substances are incompatible with PEG-based suppository bases?

All of the above Signup and view all the answers