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Questions and Answers
What is the purpose of calculating the amounts of materials needed for the preparation of one or two more suppositories than the number prescribed?
What is the purpose of calculating the amounts of materials needed for the preparation of one or two more suppositories than the number prescribed?
- To compensate for the inevitable loss of some material and ensure having enough material (correct)
- To reduce the total volume of the mold
- To decrease the melting point of the suppositories
- To increase the density of the suppositories
What does the pharmacist need to be certain of when determining the amount of base to be incorporated with the medicaments?
What does the pharmacist need to be certain of when determining the amount of base to be incorporated with the medicaments?
- The shape of the molds
- The melting point of the base
- The required amount of drug is provided in each suppository (correct)
- The color of the suppositories
How can the volume of base be converted to weight?
How can the volume of base be converted to weight?
- By estimating visually
- By measuring the pH
- By using a thermometer
- From the density of the material (correct)
When are added amounts of medicaments considered negligible?
When are added amounts of medicaments considered negligible?
What is the purpose of glycerin suppositories?
What is the purpose of glycerin suppositories?
What components are often found in anti-hemorrhoidal suppositories?
What components are often found in anti-hemorrhoidal suppositories?
What is the purpose of local vaginal suppositories containing nonoxynol-9?
What is the purpose of local vaginal suppositories containing nonoxynol-9?
Which material is used as a base to prolong the release of morphine sulfate in slow-release suppositories?
Which material is used as a base to prolong the release of morphine sulfate in slow-release suppositories?
What is the purpose of moistening the suppositories with water prior to insertion?
What is the purpose of moistening the suppositories with water prior to insertion?
What is the most commonly used polyethylene glycol for suppositories?
What is the most commonly used polyethylene glycol for suppositories?
Why do PEG suppositories not melt at body temperature?
Why do PEG suppositories not melt at body temperature?
What do the numeric designations refer to in polyethylene glycols?
What do the numeric designations refer to in polyethylene glycols?
What is the displacement value (D.V) defined as?
What is the displacement value (D.V) defined as?
If the density of the drug is less than the density of the base, what will happen?
If the density of the drug is less than the density of the base, what will happen?
Using the displacement value method, how much base will be displaced if 0.6g of drug with a displacement value of 1.1 is used?
Using the displacement value method, how much base will be displaced if 0.6g of drug with a displacement value of 1.1 is used?
What is the calculation to determine the amount of base needed using displacement values?
What is the calculation to determine the amount of base needed using displacement values?
Cocoa butter is a water-soluble suppository base
Cocoa butter is a water-soluble suppository base
Glycerinated gelatin is a water-soluble suppository base
Glycerinated gelatin is a water-soluble suppository base
Cocoa butter has wetting and emulsifying properties
Cocoa butter has wetting and emulsifying properties
Suppository bases should remain solid at body temperature
Suppository bases should remain solid at body temperature
PEG suppositories melt at body temperature.
PEG suppositories melt at body temperature.
Moistening the suppositories with water prior to insertion increases their tendency to irritate the tissues.
Moistening the suppositories with water prior to insertion increases their tendency to irritate the tissues.
The numeric designations of polyethylene glycols refer to their chain lengths.
The numeric designations of polyethylene glycols refer to their chain lengths.
PEG 8000 has a melting range of 60°C - 63°C.
PEG 8000 has a melting range of 60°C - 63°C.
Cocoa butter releases fat-soluble drugs readily due to its immiscibility with fluids.
Cocoa butter releases fat-soluble drugs readily due to its immiscibility with fluids.
The pH of rectal fluids is essentially neutral at pH 7.
The pH of rectal fluids is essentially neutral at pH 7.
The particle size of a dispersed drug is not a physicochemical factor of the drug.
The particle size of a dispersed drug is not a physicochemical factor of the drug.
The lipid-water partition coefficient of a drug is not an important consideration in the selection of the suppository base.
The lipid-water partition coefficient of a drug is not an important consideration in the selection of the suppository base.
The displacement value (D.V) is defined as the quantity of base that displaces one part of the drug.
The displacement value (D.V) is defined as the quantity of base that displaces one part of the drug.
If the density of the drug is more than the density of the base, the drug will displace a low amount of base.
If the density of the drug is more than the density of the base, the drug will displace a low amount of base.
The displacement value (D.V) for liquids is 1.5.
The displacement value (D.V) for liquids is 1.5.
When preparing 8 codeine phosphate suppositories with a displacement value of 1.1 and each suppository containing 60mg of codeine phosphate, the total weight of pure base needed is 9.45g.
When preparing 8 codeine phosphate suppositories with a displacement value of 1.1 and each suppository containing 60mg of codeine phosphate, the total weight of pure base needed is 9.45g.
What weight of base would be displaced by the medicament when preparing the medicated suppositories?
What weight of base would be displaced by the medicament when preparing the medicated suppositories?
Which factor must be considered in displacement value calculations when using glycero-gelatin base for suppositories?
Which factor must be considered in displacement value calculations when using glycero-gelatin base for suppositories?
What is the most commonly used base for vaginal suppositories?
What is the most commonly used base for vaginal suppositories?
In the displacement value method, how much base will be displaced if 0.6g of drug with a displacement value of 1.3 is used?
In the displacement value method, how much base will be displaced if 0.6g of drug with a displacement value of 1.3 is used?
Which type of suppository base is suitable for releasing fat-soluble drugs more readily?
Which type of suppository base is suitable for releasing fat-soluble drugs more readily?
What is the main purpose of using a water-soluble or water-miscible suppository base?
What is the main purpose of using a water-soluble or water-miscible suppository base?
What characteristic of suppository bases makes cocoa butter superior for relieving irritation or inflammation in anorectal disorders?
What characteristic of suppository bases makes cocoa butter superior for relieving irritation or inflammation in anorectal disorders?
What is the primary requisite for a suppository base according to the provided text?
What is the primary requisite for a suppository base according to the provided text?
Why does the pharmacist calculate the amounts of materials needed for the preparation of one or two more suppositories than the number prescribed?
Why does the pharmacist calculate the amounts of materials needed for the preparation of one or two more suppositories than the number prescribed?
How can the volume of base required for suppository preparation be determined?
How can the volume of base required for suppository preparation be determined?
Why may added amounts of medicaments be considered negligible in the preparation of suppositories?
Why may added amounts of medicaments be considered negligible in the preparation of suppositories?
Why is it necessary to convert the volume of base to weight from its density?
Why is it necessary to convert the volume of base to weight from its density?
What should be done to the suppository molds to ensure the desired smoothness of the suppositories?
What should be done to the suppository molds to ensure the desired smoothness of the suppositories?
How are suppositories prepared using the compression method?
How are suppositories prepared using the compression method?
What is the oldest and simplest method of preparing suppositories?
What is the oldest and simplest method of preparing suppositories?
How can suppositories be prepared on a large scale in the compression method?
How can suppositories be prepared on a large scale in the compression method?
What is the purpose of buffering vaginal suppositories to an acid pH?
What is the purpose of buffering vaginal suppositories to an acid pH?
What makes vaginal tablets more widely used than commercial vaginal suppositories?
What makes vaginal tablets more widely used than commercial vaginal suppositories?
What type of substances are commonly found in vaginal tablets (vaginal inserts)?
What type of substances are commonly found in vaginal tablets (vaginal inserts)?
What is the purpose of the plastic inserter that accompanies vaginal tablets?
What is the purpose of the plastic inserter that accompanies vaginal tablets?
Why are many vaginal inserts in the form of gelatin capsules?
Why are many vaginal inserts in the form of gelatin capsules?
