Podcast
Questions and Answers
What is the result of modifying the sulfonamide antibacterial with a urea moiety in sulfonylureas?
What is the result of modifying the sulfonamide antibacterial with a urea moiety in sulfonylureas?
- Hypoglycemic effects (correct)
- Increased insulin sensitivity
- Enhanced insulin secretion
- Improved glucose tolerance
What is the characteristic of the sulfonyl group in sulfonylureas?
What is the characteristic of the sulfonyl group in sulfonylureas?
- Presence of a phosphate group and oxygen atoms for hydrogen bonding
- Presence of an acidic amine and oxygen atoms for hydrogen bonding (correct)
- Presence of a hydrophobic group
- Presence of a basic amine and nitrogen atoms for hydrogen bonding
What is the significance of the para position of the phenyl ring in first-generation sulfonylureas?
What is the significance of the para position of the phenyl ring in first-generation sulfonylureas?
- It influences the lipophilicity of the drug
- It has a small lipophilic substituent that enhances activity (correct)
- It affects the binding to the ATP-sensitive K+ channel
- It determines the potency of the drug
What is the effect of having an alkyl or cyclic lipophilic substituent on the non-sulfonyl-attached urea nitrogen in first-generation sulfonylureas?
What is the effect of having an alkyl or cyclic lipophilic substituent on the non-sulfonyl-attached urea nitrogen in first-generation sulfonylureas?
What is the consequence of requiring high doses of first-generation sulfonylureas for effectiveness?
What is the consequence of requiring high doses of first-generation sulfonylureas for effectiveness?
What is the mechanism of action of sulfonylureas in terms of insulin secretion?
What is the mechanism of action of sulfonylureas in terms of insulin secretion?
What is the primary mechanism by which second-generation sulfonylureas achieve their therapeutic effect?
What is the primary mechanism by which second-generation sulfonylureas achieve their therapeutic effect?
Which of the following sulfonylureas is preferred in elderly patients due to its faster onset and shorter duration of action?
Which of the following sulfonylureas is preferred in elderly patients due to its faster onset and shorter duration of action?
What is a common adverse effect of sulfonylureas, particularly in elderly patients, liver disease, and renal disease?
What is a common adverse effect of sulfonylureas, particularly in elderly patients, liver disease, and renal disease?
What is a characteristic of second-generation sulfonylureas compared to first-generation sulfonylureas?
What is a characteristic of second-generation sulfonylureas compared to first-generation sulfonylureas?
Which of the following sulfonylureas has antiplatelet action?
Which of the following sulfonylureas has antiplatelet action?
What is the primary route of excretion for sulfonylureas and their metabolites?
What is the primary route of excretion for sulfonylureas and their metabolites?
What is the primary cause of Type 2 diabetes?
What is the primary cause of Type 2 diabetes?
What is a common adverse effect of insulin use?
What is a common adverse effect of insulin use?
What is the mechanism of action of Sulfonylureas?
What is the mechanism of action of Sulfonylureas?
What is the extrapancreatic action of Sulfonylureas?
What is the extrapancreatic action of Sulfonylureas?
What is a common cause of Acute Insulin Resistance?
What is a common cause of Acute Insulin Resistance?
What is the binding site of Sulfonylureas on pancreatic b-cells?
What is the binding site of Sulfonylureas on pancreatic b-cells?
