Oral Hypoglycemic Agents Overview
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Questions and Answers

How many families are in Oral Hypoglycemic agents?

5 families

What are the 5 families of Oral hypoglycemic agents?

Sulfonylureas, Meglitnides, Biguanides, Thiazolidinediones (glitazones), Alpha-glucosidase inhibitors

Are there any oral insulins?

False

What are the oral hypoglycemic agents indicated for?

<p>Type II diabetes</p> Signup and view all the answers

What should these antidiabetic agents correct?

<p>Hyperglycemia, Prevent microvascular complications, Improve known cardiovascular disease risk factors, Prevent microvascular complications, Correct pathophysiological disturbances responsible for Type II diabetes</p> Signup and view all the answers

What is the first class of Oral Hypoglycemic agents?

<p>Sulfonylureas</p> Signup and view all the answers

Sulfonylureas is the first step therapy available.

<p>True</p> Signup and view all the answers

What do Sulfonylureas promote?

<p>Insulin release</p> Signup and view all the answers

What are the derivatives of the sulfonamide antibiotic?

<p>Sulfonylureas</p> Signup and view all the answers

What should you check if they have a sulfa drug allergy?

<p>Glucotrol, which is a Sulfonylurea</p> Signup and view all the answers

What are the First generation of Sulfonylureas?

<p>Glucotrol, Micronase, Diabeta</p> Signup and view all the answers

What is a common Second generation Sulfonylurea?

<p>Amaryl</p> Signup and view all the answers

For Sulfonylureas, you must have working what?

<p>Beta Cells</p> Signup and view all the answers

How do Sulfonylureas work?

<p>Bind to ATP-sensitive potassium channels, leading to insulin release</p> Signup and view all the answers

What can Sulfonylureas cause?

<p>Hypoglycemia</p> Signup and view all the answers

As a nurse, what should you check first?

<p>Blood sugar</p> Signup and view all the answers

What are other drugs that can decrease blood sugar?

<p>NSAIDs (no ibuprofen), Sulfonamide antibiotics, Alcohol (large amounts), Cimetidine (Tagamet)</p> Signup and view all the answers

Study Notes

Oral Hypoglycemic Agents Overview

  • Five families of oral hypoglycemic agents are recognized.
  • Families include Sulfonylureas, Meglitinides, Biguanides, Thiazolidinediones (glitazones), and Alpha-glucosidase inhibitors.

Specifics on Sulfonylureas

  • Sulfonylureas are the first line of therapy for Type II diabetes.
  • They function as insulin secretagogues, promoting insulin release from beta cells in the pancreas.
  • Individuals with sulfa drug allergies should avoid Sulfonylureas, such as Glucotrol.
  • First generation Sulfonylureas include Glucotrol, Micronase, and Diabeta.
  • The common second generation Sulfonylurea is Amaryl.

Mechanism and Action

  • Designed to correct hyperglycemia and prevent microvascular complications.
  • Aim to improve known cardiovascular disease risk factors and rectify pathophysiological disturbances in Type II diabetes.
  • Require functioning beta cells for efficacy.

Side Effects and Nursing Considerations

  • Sulfonylureas can lead to hypoglycemia.
  • Blood sugar levels should be monitored closely, as these medications increase insulin secretion rather than directly lowering blood sugar.

Drug Interactions

  • Certain drugs can also lower blood sugar levels, including:
    • Nonsteroidal anti-inflammatory drugs (NSAIDs), excluding ibuprofen.
    • Sulfonamide antibiotics.
    • High amounts of alcohol.
    • Cimetidine (Tagamet), which is an H2 blocker that reduces stomach acid.

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Description

This quiz covers the families of oral hypoglycemic agents, focusing on Sulfonylureas and their mechanism of action in treating Type II diabetes. It also addresses essential nursing considerations and potential side effects for patients. Test your knowledge on these critical diabetes management medications.

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