Questions and Answers
What is the trade name for Succinylcholine?
What is the classification of Succinylcholine?
Neuromuscular blocker, depolarizing
What is the mechanism of action of Succinylcholine?
Competes with the acetylcholine receptor of the motor end plate on the muscle cell, results in muscle paralysis.
What are the indications for Succinylcholine?
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Succinylcholine can cause ___ reactions.
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List some adverse reactions of Succinylcholine.
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What are the contraindications for Succinylcholine?
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Use caution with Succinylcholine in patients with ___ and cardiac disease.
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What is the dosage for adults taking Succinylcholine?
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What are some special considerations for administering Succinylcholine?
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Study Notes
Succinylcholine Overview
- Trade name: Anectine
- Classification: Neuromuscular blocker, depolarizing agent
Mechanism of Action
- Competes with acetylcholine at the motor end plate of muscle cells
- Results in muscle paralysis necessary for procedures
Indications
- Used to induce neuromuscular blockade for facilitating endotracheal (ET) intubation
Adverse Reactions
- Anaphylatoid reactions
- Respiratory depression and apnea
- Bronchospasm and cardiac arrhythmias
- Malignant hyperthermia and hypertension
- Hypotension, muscle fasciculation, and post-procedure muscle pain
- Hypersalivation and rash
Contraindications
- Malignant hyperthermia
- Burns and trauma
Cautions
- Use with caution in patients with cardiac, hepatic, and renal diseases
- Consider in cases of peptic ulcer disease, cholinesterase-inhibitor toxicity, and pseudocholinesterase deficiency
- Watch for risks in digitalis toxicity, glaucoma, hyperkalemia, hypothermia, rhabdomyolysis, and myasthenia gravis
Dosage
- Adult IV/IO: 0.6 mg/kg (range 0.3-1.1 mg/kg); IM: 3-4 mg/kg (max 150 mg)
- Pediatric IV/IO: Adolescents and older children: 1 mg/kg; Small children/infants: 2 mg/kg; IM: 3-4 mg/kg (max 150 mg)
Special Considerations
- Pregnancy category: C
- IV administration: Neuromuscular blockade occurs within 0.5-1 minute; IM administration: effects in 2-3 minutes
- In infants and children, IV use can lead to profound bradycardia or asystole, especially after the second dose
- Bradycardia risk can be decreased by pretreatment with atropine
- Prolonged effects noted in cases of poisoning with nerve agents and organophosphate pesticides
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This quiz provides flashcards focused on the drug succinylcholine, including its trade name, classification, mechanism of action, and indications. Ideal for students and healthcare professionals looking to reinforce their knowledge of this neuromuscular blocker.