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Questions and Answers
What is the primary mechanism of action of depolarizing NMJ blockers like succinylcholine?
What is the primary mechanism of action of depolarizing NMJ blockers like succinylcholine?
- Preventing the release of acetylcholine
- Blocking the reuptake of acetylcholine
- Inhibiting the synthesis of acetylcholine
- Attaching to the ACh receptor site, causing prolonged depolarization (correct)
Depolarizing NMJ blockers share which therapeutic action with non-depolarizing blockers?
Depolarizing NMJ blockers share which therapeutic action with non-depolarizing blockers?
- Muscle relaxation for surgical procedures (correct)
- Bronchodilation
- Analgesia
- Reversal of neuromuscular blockade by neostigmine
What is a notable characteristic of succinylcholine that makes it suitable for rapid sequence intubation (RSI)?
What is a notable characteristic of succinylcholine that makes it suitable for rapid sequence intubation (RSI)?
- Minimal adverse effects
- Long half-life
- Short half-life (correct)
- Lack of contraindications
Which is a major similarity between depolarizing and non-depolarizing NMJ blockers?
Which is a major similarity between depolarizing and non-depolarizing NMJ blockers?
What specific warning is associated with depolarizing NMJ blockers?
What specific warning is associated with depolarizing NMJ blockers?
Depolarizing NMJ blockers' cautions are MOST similar to which other drug type?
Depolarizing NMJ blockers' cautions are MOST similar to which other drug type?
What is an effect caused by depolarizing NMJ blockers attaching to ACh receptor sites?
What is an effect caused by depolarizing NMJ blockers attaching to ACh receptor sites?
During rapid sequence intubation, what is the MOST important reason for using succinylcholine?
During rapid sequence intubation, what is the MOST important reason for using succinylcholine?
What is the main effect of succinylcholine on the muscle cell?
What is the main effect of succinylcholine on the muscle cell?
If a medication shares the same therapeutic actions, contraindications, and adverse effects as a non-depolarizing agent, what can be inferred?
If a medication shares the same therapeutic actions, contraindications, and adverse effects as a non-depolarizing agent, what can be inferred?
What risks are associated with the black box warning for Depolarizing NMJ Blockers?
What risks are associated with the black box warning for Depolarizing NMJ Blockers?
Flashcards
Succinylcholine: Mechanism of Action
Succinylcholine: Mechanism of Action
Attaches to ACh receptor site on muscle cell, causing prolonged depolarization.
Succinylcholine: Contraindications & Cautions
Succinylcholine: Contraindications & Cautions
Similar to non-depolarizing blockers, but with a Black Box Warning.
Succinylcholine: Adverse Effects
Succinylcholine: Adverse Effects
The same as non-depolarizing neuromuscular blocking agents.
Succinylcholine: Use in RSI
Succinylcholine: Use in RSI
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Study Notes
- Depolarizing NMJ blockers like Succinylcholine attach to ACh receptors on muscle cells, causing prolonged depolarization.
- The therapeutic actions and indications mirror those of non-depolarizing agents.
- Contraindications are the same as non-depolarizing agents.
- Use with caution, includes a black box warning, similar to non-depolarizing agents.
- Adverse effects are similar to non-depolarizing agents.
- Succinylcholine is often the first choice during rapid sequence intubation (RSI) because of its short half-life.
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