Depolarizing Muscle Relaxants

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Questions and Answers

In a patient with atypical pseudocholinesterase, which of the following dibucaine numbers would suggest a heterozygous variant?

  • 90:10
  • 80:20
  • 50:50 (correct)
  • 20:80

Which of the following neuromuscular blocking agents is most likely to cause seizures due to laudanosine release on prolonged infusion?

  • Atracurium (correct)
  • Rocuronium
  • Cisatracurium
  • Vecuronium

A patient with a history of hypertension and coronary artery disease requires neuromuscular blockade for surgery. Which neuromuscular blocking agent should be avoided due to its potential to increase heart rate and blood pressure?

  • Atracurium
  • Cisatracurium
  • Pancuronium (correct)
  • Vecuronium

Which volatile anesthetic agent is least ideal for inhalational induction due to its pungent smell, often causing coughing and laryngospasm?

<p>Desflurane (D)</p> Signup and view all the answers

In a patient undergoing a short surgical procedure, which opioid analgesic would be most suitable given its rapid onset and shortest duration of action?

<p>Remifentanil (D)</p> Signup and view all the answers

A patient with acute liver failure requires neuromuscular blockade. Which agent's duration of action would be least affected by this condition?

<p>Atracurium (A)</p> Signup and view all the answers

A patient undergoing general anesthesia experiences bradycardia and increased oral secretions. Which medication would be most appropriate to administer?

<p>Atropine (C)</p> Signup and view all the answers

A patient with a known history of malignant hyperthermia requires neuromuscular blockade. Which of the following agents is absolutely contraindicated?

<p>Succinylcholine (B)</p> Signup and view all the answers

Which of the following is the most reliable clinical sign of adequate reversal of neuromuscular blockade?

<p>Ability to lift head &gt;5 seconds (D)</p> Signup and view all the answers

During anesthesia, a patient develops unexpected prolonged muscle paralysis following succinylcholine administration. Which of the following conditions is least likely to be the cause?

<p>Hyperkalemia (A)</p> Signup and view all the answers

You are planning a day-care surgery for a patient. Which neuromuscular blocking agent is least suitable?

<p>Pancuronium (B)</p> Signup and view all the answers

Which of the following is a disadvantage of using pancuronium?

<p>Avoidance in cardiac patients (D)</p> Signup and view all the answers

In a patient undergoing a laparoscopic procedure, which of the following considerations regarding post-operative analgesia is most important?

<p>Ensuring pain control methods do not prolong hospital stay (D)</p> Signup and view all the answers

What is the significance of the dibucaine number in the context of pseudocholinesterase activity?

<p>It assesses the qualitative variant and affinity of pseudocholinesterase. (A)</p> Signup and view all the answers

A 2-year-old child is scheduled for a minor surgical procedure. Regarding the use of succinylcholine, which of the following statements is most accurate?

<p>Succinylcholine should be avoided due to possibility of undiagnosed myopathy (D)</p> Signup and view all the answers

A patient needs to be intubated in the ER with RSI, which property would be MOST desirable for the NMB selected?

<p>Rapid onset of action. (C)</p> Signup and view all the answers

After administering succinylcholine, a patient develops bradyarrhythmia. Which medication should be immediately administered?

<p>Atropine (A)</p> Signup and view all the answers

Which of the following statements accurately characterizes the mechanism of action and metabolism of succinylcholine?

<p>It is a depolarizing muscle relaxant metabolized by pseudocholinesterase. (C)</p> Signup and view all the answers

In the context of day care anesthesia, which of the following represents an ideal combination of neuromuscular blocking agent and reversal agent that facilitates rapid recovery and discharge?

<p>Rocuronium and sugammadex (B)</p> Signup and view all the answers

Which of the following is not a reason for prolonged duration of action following succinylcholine administration?

<p>Increased levels of normal pseudocholinesterase (C)</p> Signup and view all the answers

In a patient undergoing a surgical procedure, which of the following clinical scenarios necessitates cautious use or avoidance of succinylcholine?

<p>Hyperkalemia (C)</p> Signup and view all the answers

Which of the following best describes the appropriate initial dose of neostigmine for reversal of neuromuscular blockade?

<p>0.05 - 0.07 mg/kg (B)</p> Signup and view all the answers

Which agent, when combined with rocuronium, allows for rapid reversal of neuromuscular blockade, making it particularly useful in scenarios requiring quick recovery?

<p>Sugammadex (A)</p> Signup and view all the answers

In pediatric anesthesia, what is the primary reason for avoiding the use of un-cuffed endotracheal tubes?

<p>They increase the risk for laryngeal edema (B)</p> Signup and view all the answers

What is the significance of aiming for spontaneous breathing with a normal ETCO2 during reversal from neuromuscular blockade?

<p>It helps avoid the 'curare cleft' and ensures coordinated breathing. (D)</p> Signup and view all the answers

Which of the following is the significance of maintaining the operating room temperature between 27-28°C during pediatric anesthesia?

<p>To minimize the risk of hypothermia. (B)</p> Signup and view all the answers

A child is undergoing anesthesia, and it is determined that a Miller blade will be used. Which statement best describes the Miller blade?

<p>It is straight and designed to directly lift the epiglottis. (A)</p> Signup and view all the answers

What concentration of lignocaine and prilocaine are present in EMLA cream?

<p>2.5% Lignocaine + 2.5% Prilocaine (D)</p> Signup and view all the answers

During caudal anesthesia, at which vertebral junction is the injection typically administered?

<p>S4-S5 (D)</p> Signup and view all the answers

Which of the following is most concerning in the postoperative period following caudal anesthesia among pediatric patients?

<p>Increased risk of infection due to bowel and bladder immaturity (C)</p> Signup and view all the answers

According to the modified Aldrete scoring system, what score indicates that a patient is fit for discharge following anesthesia?

<p>≥ 9 (D)</p> Signup and view all the answers

During day-care anesthesia, which factor would be a contraindication?

<p>Procedure anticipated to take longer than 90 minutes (D)</p> Signup and view all the answers

A patient undergoing day-care anesthesia develops drowsiness, nausea, and vomiting. What medication may be preferred?

<p>Ondansetron (C)</p> Signup and view all the answers

Compared to other methods for maintenance of normothermia, which way is LEAST effective?

<p>Administering cold IVF (D)</p> Signup and view all the answers

Which of the following best explains why succinylcholine is typically avoided in children under one year of age?

<p>Higher incidence of undiagnosed myopathies. (A)</p> Signup and view all the answers

A patient with atypical pseudocholinesterase requires neuromuscular blockade. Understanding the nuances of dibucaine numbers, which clinical intervention would be most appropriate based on this condition?

<p>Planning for prolonged mechanical ventilation post-procedure. (A)</p> Signup and view all the answers

In a patient with significant cardiovascular disease, which neuromuscular blocking agent should be avoided due to its propensity to cause tachycardia and hypertension through its vagolytic effects and potential for increased heart rate and blood pressure?

<p>Pancuronium (A)</p> Signup and view all the answers

A patient with combined liver and kidney failure requires neuromuscular blockade. Which agent below would be most appropriate, considering its clearance pathway?

<p>Cisatracurium (D)</p> Signup and view all the answers

Following prolonged infusion of atracurium, a patient exhibits signs of neurological excitation. Which metabolite of atracurium is the most likely cause of this adverse effect?

<p>Laudanosine (D)</p> Signup and view all the answers

Flashcards

Muscle Relaxants (DMR)

Aids in intubation and surgical relaxation.

Succinylcholine: Mechanism

Acts as a non-competitive blockade at the Ach receptor and is metabolized by pseudocholinesterase.

Succinylcholine: AOC

Difficult intubation and rapid sequence intubation.

Succinylcholine: Contraindications

Family history of malignant hyperthermia and muscular dystrophies, preexisting hyperkalemia, burns, acute liver failure, sepsis, and hemiplegia/paraplegia.

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Reasons for prolonged Succinylcholine action

Acute liver failure, neonates, pregnancy, drugs (pyridostigmine), and organophosphate poisoning.

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Succinylcholine - Phase II block

Phase II block: Succinylcholine >5mg/kg; receptor damage. Rx: Mechanical ventilation.

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Atypical pseudocholinesterase

Qualitatively assessed by dibucaine number which indicates affinity to pseudocholinesterase.

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Atypical pseudocholinesterase: Rx

Continue mechanical ventilation and administer fresh frozen plasma.

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Pancuronium: Disadvantages

Avoid in day-care Sx. C/I: HTN & cardiac patients (↑HR & BP)

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Vecuronium

Excretion: Bile; AOC: Cardiac & neuro Sx

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Atracurium

metabolism: Hoffman's degradation (Non-enzymatic/non organ dependant clearance)

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Reversal of Block: Neostigmine

Dose: 0.05 - 0.07 mg/kg. Administered on spontaneous breathing (Etco2 : Curare cleft).

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Neostigmine: Side effects

Side effect: Bradycardia/↑ Oral secretions → Rx: Atropine/Glycopyrrolate.

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Sugammadex

Acts as a Cyclodextrin molecule and is used for reversal of vecuronium/Rocuronium.

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Sugammadex: Side effects

Side effects: Anaphylaxis and Contraceptive failure.

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Signs of adequate reversal

Regular respiration & adequate tidal volume, Spontaneous eye opening, Spontaneous limb movement.

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Signs of adequate reversal continued

Able to protrude tongue, cough (No cyanosis), Able to lift head >5 sec (most reliable bedside test).

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Preoperative Preparation.

Benzodiazepine syrup (midazolam), Ketamine Im : 4-6 mg/kg, Parental accompaniment in OT.

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Fasting guidelines:

2 hours: Clear liquids, 4 hours: Breast milk, 6 hours: Solids (Except breast milk), 8 hours: Heavy fatty meal.

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EMLA Cream

Eutectic mixture of Lignocaine (2.5%) + Prilocaine (2.5%). used for superficial procedures (Iv cannulation).

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Induction of anaesthesia:

AOC: Sevoflurane > Halothane.

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Muscle relaxant

AOC: Vecuronium/Atracurium. →Avoid: Succinylcholine in <1 year.

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Analgesic:

Fentanyl 1-2 mcg/kg.

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Airway management

ETT: Microcuffed > uncuffed ETT.

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Prevention of hypothermia.

OT temperature: 27-28°C, Warm fluids & heating devices.

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Post-Operative Analgesia: Caudal anaesthesia:

No risk of spinal cord injury. Administered only in postoperative phase in children.

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IV induction

Agent of choice: Propofol.

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Post Operative Considerations

Discharge of patient : modified Aldrette Scoring System → Fit for discharge if >9.

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Study Notes

  • Muscle Relaxants: DMR aids in intubation and surgical relaxation.

Depolarizing Muscle Relaxants (DMR)

  • Succinylcholine has 2 molecules of ACh
    • Dosage: 1-2 mg/kg
    • Duration: less than 10 minutes
    • Onset of action: 30 seconds
    • Action of concern includes difficult intubation/rapid sequence intubation

Mechanism of Action

  • Non-competitive blockade at the ACh receptor
  • Metabolized by pseudocholinesterase (PSE) that is produced by the liver

Systemic Effects

  • Bradyarrhythmia treated with Atropine/Glycopyrrolate
  • Muscle fasciculations can cause post-operative myalgia
  • Increased ICP, IOP, and intragastric pressure, which decreases chances of aspiration
  • Can cause anaphylaxis

Contraindications

  • Family history of malignant hyperthermia and muscular dystrophies
  • Preexisting hyperkalemia
  • Burns
  • Acute liver failure
  • Sepsis
  • Hemiplegia/paraplegia

Reasons For Prolonged Duration of Action

  • Decreased concentration of PSE can be caused by acute liver failure, neonates, and pregnancy
  • Decreased PSE enzyme activity can be caused by atypical pseudocholinesterase
  • Phase II block: Succinylcholine >5mg/kg results in receptor damage
    • Treat with mechanical ventilation
    • Resembles NDMR block, however, Neostigmine is contraindicated

Atypical Pseudocholinesterase

  • Quantitatively assessed by dibucaine number; increased affinity to pseudocholinesterase
    • Continue mechanical ventilation
    • Fresh frozen plasma

Types of Pseudocholinesterase

  • Normal: Dibucaine number 80:20 and duration less than 10 min
  • Heterozygous variant: Dibucaine number 50:50 and duration of 45-60min
  • Homozygous variant: Dibucaine number 20:80 and duration of 6-8 hours

Signs of Adequate Reversal

  • Regular respiration and adequate tidal volume
  • Spontaneous eye opening and limb movement
  • Able to protrude tongue and cough without cyanosis
  • Able to lift head for more than 5 seconds (most reliable bedside test)

Pediatric Surgeries

  • Preoperative preparation to decrease anxiety can be achieved through benzodiazepine syrup (Midazolam), Ketamine IM (4-6 mg/kg), and parental accompaniment in OT for children older than 6 months

Fasting guidelines

  • 2 hours for clear liquids
  • 4 hours for breast milk
  • 6 hours for solids (except breast milk)
  • 8 hours for heavy fatty meals

Note

  • EMLA Cream is a eutectic mixture of Lignocaine (2.5%) and Prilocaine (2.5%) used for superficial procedures like IV cannulation

Intraoperative Considerations

  • Inhalational induction of anesthesia is preferred, using Sevoflurane over Halothane
  • Muscle relaxant: Vecuronium/Atracurium
    • Avoid: Succinylcholine in less than 1-year-olds to prevent undiagnosed myopathy
  • Analgesic: Fentanyl 1-2 mcg/kg (short-acting agent)
  • Airway Management ETT: Microcuffed > uncuffed ETT and Laryngoscope: Miller’s blade
  • Maintain OT temperature between 27-28°C
  • Use warm fluids and heating devices to prevent hypothermia

Post-Operative Analgesia

  • Caudal anesthesia has no risk of spinal cord injury
    • Administered only in the postoperative phase in children
    • Risk of infection due to bowel and bladder immaturity

Day Care Anesthesia

  • Characterized by same-day admission, operation, and discharge
    • Decreased risk of hospital infection
    • All regional anesthesia procedures can be conducted in a day care setting

Patient Factors

  • Consider ASA grades I & II or III (in well-controlled diseases)
    • Caution with extreme ages (premature babies/ >85 years)
    • Patient stays near the hospital and has a responsible caregiver

Procedure Factors

  • Indications include: Laparoscopic Sx
  • Contraindications: Procedures anticipating post-op complications and Duration >90 minutes

Anesthetic Factors

  • IV induction agent of choice: Propofol (short acting)
  • Inhalational: Sevoflurane (sweet smelling) > Desflurane (irritant)
  • Muscle relaxant: Rocuronium & Sugammadex > Mivacurium
  • Opioid: Remifentanil (shortest), Fentanyl
  • Local anesthesia: Chlorprocaine (shortest)

Post Operative Considerations

  • Discharge criteria: Modified Aldrette Scoring System. Fit for discharge if greater than >9
  • Complications include drowsiness, nausea, and vomiting
  • Common cause for readmission is Hemorrhage

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