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Questions and Answers
In a patient with atypical pseudocholinesterase, which of the following dibucaine numbers would suggest a heterozygous variant?
In a patient with atypical pseudocholinesterase, which of the following dibucaine numbers would suggest a heterozygous variant?
- 90:10
- 80:20
- 50:50 (correct)
- 20:80
Which of the following neuromuscular blocking agents is most likely to cause seizures due to laudanosine release on prolonged infusion?
Which of the following neuromuscular blocking agents is most likely to cause seizures due to laudanosine release on prolonged infusion?
- Atracurium (correct)
- Rocuronium
- Cisatracurium
- Vecuronium
A patient with a history of hypertension and coronary artery disease requires neuromuscular blockade for surgery. Which neuromuscular blocking agent should be avoided due to its potential to increase heart rate and blood pressure?
A patient with a history of hypertension and coronary artery disease requires neuromuscular blockade for surgery. Which neuromuscular blocking agent should be avoided due to its potential to increase heart rate and blood pressure?
- Atracurium
- Cisatracurium
- Pancuronium (correct)
- Vecuronium
Which volatile anesthetic agent is least ideal for inhalational induction due to its pungent smell, often causing coughing and laryngospasm?
Which volatile anesthetic agent is least ideal for inhalational induction due to its pungent smell, often causing coughing and laryngospasm?
In a patient undergoing a short surgical procedure, which opioid analgesic would be most suitable given its rapid onset and shortest duration of action?
In a patient undergoing a short surgical procedure, which opioid analgesic would be most suitable given its rapid onset and shortest duration of action?
A patient with acute liver failure requires neuromuscular blockade. Which agent's duration of action would be least affected by this condition?
A patient with acute liver failure requires neuromuscular blockade. Which agent's duration of action would be least affected by this condition?
A patient undergoing general anesthesia experiences bradycardia and increased oral secretions. Which medication would be most appropriate to administer?
A patient undergoing general anesthesia experiences bradycardia and increased oral secretions. Which medication would be most appropriate to administer?
A patient with a known history of malignant hyperthermia requires neuromuscular blockade. Which of the following agents is absolutely contraindicated?
A patient with a known history of malignant hyperthermia requires neuromuscular blockade. Which of the following agents is absolutely contraindicated?
Which of the following is the most reliable clinical sign of adequate reversal of neuromuscular blockade?
Which of the following is the most reliable clinical sign of adequate reversal of neuromuscular blockade?
During anesthesia, a patient develops unexpected prolonged muscle paralysis following succinylcholine administration. Which of the following conditions is least likely to be the cause?
During anesthesia, a patient develops unexpected prolonged muscle paralysis following succinylcholine administration. Which of the following conditions is least likely to be the cause?
You are planning a day-care surgery for a patient. Which neuromuscular blocking agent is least suitable?
You are planning a day-care surgery for a patient. Which neuromuscular blocking agent is least suitable?
Which of the following is a disadvantage of using pancuronium?
Which of the following is a disadvantage of using pancuronium?
In a patient undergoing a laparoscopic procedure, which of the following considerations regarding post-operative analgesia is most important?
In a patient undergoing a laparoscopic procedure, which of the following considerations regarding post-operative analgesia is most important?
What is the significance of the dibucaine number in the context of pseudocholinesterase activity?
What is the significance of the dibucaine number in the context of pseudocholinesterase activity?
A 2-year-old child is scheduled for a minor surgical procedure. Regarding the use of succinylcholine, which of the following statements is most accurate?
A 2-year-old child is scheduled for a minor surgical procedure. Regarding the use of succinylcholine, which of the following statements is most accurate?
A patient needs to be intubated in the ER with RSI, which property would be MOST desirable for the NMB selected?
A patient needs to be intubated in the ER with RSI, which property would be MOST desirable for the NMB selected?
After administering succinylcholine, a patient develops bradyarrhythmia. Which medication should be immediately administered?
After administering succinylcholine, a patient develops bradyarrhythmia. Which medication should be immediately administered?
Which of the following statements accurately characterizes the mechanism of action and metabolism of succinylcholine?
Which of the following statements accurately characterizes the mechanism of action and metabolism of succinylcholine?
In the context of day care anesthesia, which of the following represents an ideal combination of neuromuscular blocking agent and reversal agent that facilitates rapid recovery and discharge?
In the context of day care anesthesia, which of the following represents an ideal combination of neuromuscular blocking agent and reversal agent that facilitates rapid recovery and discharge?
Which of the following is not a reason for prolonged duration of action following succinylcholine administration?
Which of the following is not a reason for prolonged duration of action following succinylcholine administration?
In a patient undergoing a surgical procedure, which of the following clinical scenarios necessitates cautious use or avoidance of succinylcholine?
In a patient undergoing a surgical procedure, which of the following clinical scenarios necessitates cautious use or avoidance of succinylcholine?
Which of the following best describes the appropriate initial dose of neostigmine for reversal of neuromuscular blockade?
Which of the following best describes the appropriate initial dose of neostigmine for reversal of neuromuscular blockade?
Which agent, when combined with rocuronium, allows for rapid reversal of neuromuscular blockade, making it particularly useful in scenarios requiring quick recovery?
Which agent, when combined with rocuronium, allows for rapid reversal of neuromuscular blockade, making it particularly useful in scenarios requiring quick recovery?
In pediatric anesthesia, what is the primary reason for avoiding the use of un-cuffed endotracheal tubes?
In pediatric anesthesia, what is the primary reason for avoiding the use of un-cuffed endotracheal tubes?
What is the significance of aiming for spontaneous breathing with a normal ETCO2 during reversal from neuromuscular blockade?
What is the significance of aiming for spontaneous breathing with a normal ETCO2 during reversal from neuromuscular blockade?
Which of the following is the significance of maintaining the operating room temperature between 27-28°C during pediatric anesthesia?
Which of the following is the significance of maintaining the operating room temperature between 27-28°C during pediatric anesthesia?
A child is undergoing anesthesia, and it is determined that a Miller blade will be used. Which statement best describes the Miller blade?
A child is undergoing anesthesia, and it is determined that a Miller blade will be used. Which statement best describes the Miller blade?
What concentration of lignocaine and prilocaine are present in EMLA cream?
What concentration of lignocaine and prilocaine are present in EMLA cream?
During caudal anesthesia, at which vertebral junction is the injection typically administered?
During caudal anesthesia, at which vertebral junction is the injection typically administered?
Which of the following is most concerning in the postoperative period following caudal anesthesia among pediatric patients?
Which of the following is most concerning in the postoperative period following caudal anesthesia among pediatric patients?
According to the modified Aldrete scoring system, what score indicates that a patient is fit for discharge following anesthesia?
According to the modified Aldrete scoring system, what score indicates that a patient is fit for discharge following anesthesia?
During day-care anesthesia, which factor would be a contraindication?
During day-care anesthesia, which factor would be a contraindication?
A patient undergoing day-care anesthesia develops drowsiness, nausea, and vomiting. What medication may be preferred?
A patient undergoing day-care anesthesia develops drowsiness, nausea, and vomiting. What medication may be preferred?
Compared to other methods for maintenance of normothermia, which way is LEAST effective?
Compared to other methods for maintenance of normothermia, which way is LEAST effective?
Which of the following best explains why succinylcholine is typically avoided in children under one year of age?
Which of the following best explains why succinylcholine is typically avoided in children under one year of age?
A patient with atypical pseudocholinesterase requires neuromuscular blockade. Understanding the nuances of dibucaine numbers, which clinical intervention would be most appropriate based on this condition?
A patient with atypical pseudocholinesterase requires neuromuscular blockade. Understanding the nuances of dibucaine numbers, which clinical intervention would be most appropriate based on this condition?
In a patient with significant cardiovascular disease, which neuromuscular blocking agent should be avoided due to its propensity to cause tachycardia and hypertension through its vagolytic effects and potential for increased heart rate and blood pressure?
In a patient with significant cardiovascular disease, which neuromuscular blocking agent should be avoided due to its propensity to cause tachycardia and hypertension through its vagolytic effects and potential for increased heart rate and blood pressure?
A patient with combined liver and kidney failure requires neuromuscular blockade. Which agent below would be most appropriate, considering its clearance pathway?
A patient with combined liver and kidney failure requires neuromuscular blockade. Which agent below would be most appropriate, considering its clearance pathway?
Following prolonged infusion of atracurium, a patient exhibits signs of neurological excitation. Which metabolite of atracurium is the most likely cause of this adverse effect?
Following prolonged infusion of atracurium, a patient exhibits signs of neurological excitation. Which metabolite of atracurium is the most likely cause of this adverse effect?
Flashcards
Muscle Relaxants (DMR)
Muscle Relaxants (DMR)
Aids in intubation and surgical relaxation.
Succinylcholine: Mechanism
Succinylcholine: Mechanism
Acts as a non-competitive blockade at the Ach receptor and is metabolized by pseudocholinesterase.
Succinylcholine: AOC
Succinylcholine: AOC
Difficult intubation and rapid sequence intubation.
Succinylcholine: Contraindications
Succinylcholine: Contraindications
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Reasons for prolonged Succinylcholine action
Reasons for prolonged Succinylcholine action
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Succinylcholine - Phase II block
Succinylcholine - Phase II block
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Atypical pseudocholinesterase
Atypical pseudocholinesterase
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Atypical pseudocholinesterase: Rx
Atypical pseudocholinesterase: Rx
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Pancuronium: Disadvantages
Pancuronium: Disadvantages
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Vecuronium
Vecuronium
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Atracurium
Atracurium
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Reversal of Block: Neostigmine
Reversal of Block: Neostigmine
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Neostigmine: Side effects
Neostigmine: Side effects
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Sugammadex
Sugammadex
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Sugammadex: Side effects
Sugammadex: Side effects
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Signs of adequate reversal
Signs of adequate reversal
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Signs of adequate reversal continued
Signs of adequate reversal continued
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Preoperative Preparation.
Preoperative Preparation.
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Fasting guidelines:
Fasting guidelines:
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EMLA Cream
EMLA Cream
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Induction of anaesthesia:
Induction of anaesthesia:
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Muscle relaxant
Muscle relaxant
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Analgesic:
Analgesic:
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Airway management
Airway management
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Prevention of hypothermia.
Prevention of hypothermia.
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Post-Operative Analgesia: Caudal anaesthesia:
Post-Operative Analgesia: Caudal anaesthesia:
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IV induction
IV induction
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Post Operative Considerations
Post Operative Considerations
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Study Notes
- Muscle Relaxants: DMR aids in intubation and surgical relaxation.
Depolarizing Muscle Relaxants (DMR)
- Succinylcholine has 2 molecules of ACh
- Dosage: 1-2 mg/kg
- Duration: less than 10 minutes
- Onset of action: 30 seconds
- Action of concern includes difficult intubation/rapid sequence intubation
Mechanism of Action
- Non-competitive blockade at the ACh receptor
- Metabolized by pseudocholinesterase (PSE) that is produced by the liver
Systemic Effects
- Bradyarrhythmia treated with Atropine/Glycopyrrolate
- Muscle fasciculations can cause post-operative myalgia
- Increased ICP, IOP, and intragastric pressure, which decreases chances of aspiration
- Can cause anaphylaxis
Contraindications
- Family history of malignant hyperthermia and muscular dystrophies
- Preexisting hyperkalemia
- Burns
- Acute liver failure
- Sepsis
- Hemiplegia/paraplegia
Reasons For Prolonged Duration of Action
- Decreased concentration of PSE can be caused by acute liver failure, neonates, and pregnancy
- Decreased PSE enzyme activity can be caused by atypical pseudocholinesterase
- Phase II block: Succinylcholine >5mg/kg results in receptor damage
- Treat with mechanical ventilation
- Resembles NDMR block, however, Neostigmine is contraindicated
Atypical Pseudocholinesterase
- Quantitatively assessed by dibucaine number; increased affinity to pseudocholinesterase
- Continue mechanical ventilation
- Fresh frozen plasma
Types of Pseudocholinesterase
- Normal: Dibucaine number 80:20 and duration less than 10 min
- Heterozygous variant: Dibucaine number 50:50 and duration of 45-60min
- Homozygous variant: Dibucaine number 20:80 and duration of 6-8 hours
Signs of Adequate Reversal
- Regular respiration and adequate tidal volume
- Spontaneous eye opening and limb movement
- Able to protrude tongue and cough without cyanosis
- Able to lift head for more than 5 seconds (most reliable bedside test)
Pediatric Surgeries
- Preoperative preparation to decrease anxiety can be achieved through benzodiazepine syrup (Midazolam), Ketamine IM (4-6 mg/kg), and parental accompaniment in OT for children older than 6 months
Fasting guidelines
- 2 hours for clear liquids
- 4 hours for breast milk
- 6 hours for solids (except breast milk)
- 8 hours for heavy fatty meals
Note
- EMLA Cream is a eutectic mixture of Lignocaine (2.5%) and Prilocaine (2.5%) used for superficial procedures like IV cannulation
Intraoperative Considerations
- Inhalational induction of anesthesia is preferred, using Sevoflurane over Halothane
- Muscle relaxant: Vecuronium/Atracurium
- Avoid: Succinylcholine in less than 1-year-olds to prevent undiagnosed myopathy
- Analgesic: Fentanyl 1-2 mcg/kg (short-acting agent)
- Airway Management ETT: Microcuffed > uncuffed ETT and Laryngoscope: Miller’s blade
- Maintain OT temperature between 27-28°C
- Use warm fluids and heating devices to prevent hypothermia
Post-Operative Analgesia
- Caudal anesthesia has no risk of spinal cord injury
- Administered only in the postoperative phase in children
- Risk of infection due to bowel and bladder immaturity
Day Care Anesthesia
- Characterized by same-day admission, operation, and discharge
- Decreased risk of hospital infection
- All regional anesthesia procedures can be conducted in a day care setting
Patient Factors
- Consider ASA grades I & II or III (in well-controlled diseases)
- Caution with extreme ages (premature babies/ >85 years)
- Patient stays near the hospital and has a responsible caregiver
Procedure Factors
- Indications include: Laparoscopic Sx
- Contraindications: Procedures anticipating post-op complications and Duration >90 minutes
Anesthetic Factors
- IV induction agent of choice: Propofol (short acting)
- Inhalational: Sevoflurane (sweet smelling) > Desflurane (irritant)
- Muscle relaxant: Rocuronium & Sugammadex > Mivacurium
- Opioid: Remifentanil (shortest), Fentanyl
- Local anesthesia: Chlorprocaine (shortest)
Post Operative Considerations
- Discharge criteria: Modified Aldrette Scoring System. Fit for discharge if greater than >9
- Complications include drowsiness, nausea, and vomiting
- Common cause for readmission is Hemorrhage
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