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Substrate Selection and Regulation in the Heart

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Substrate Selection and Regulation in the Heart

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Questions and Answers

What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?

Allosteric regulation

Epinephrine regulation

FA oxidation (correct)

Insulin regulation

What inhibits PDH activity in the heart?

Increased NADH levels

High rate of FA oxidation (correct)

Lack of insulin

Low levels of glucose

How does inhibition of FA oxidation affect the uptake and oxidation of glucose and lactate in the heart?

Promotes storage of glucose and lactate

Increases uptake and oxidation of glucose and lactate (correct)

Reduces uptake and oxidation of glucose and lactate

Has no effect on glucose and lactate metabolism

What effect does a high rate of FA oxidation have on the mitochondria in terms of acetyl CoA and NADH levels?

<p>Increases acetyl CoA and NADH levels</p> Signup and view all the answers

How are FA and glucose utilization interrelated in the heart?

<p>Tightly linked and co-regulated</p> Signup and view all the answers

Substrate Selection and Regulation in the Heart

Choose a study mode

Podcast

Questions and Answers

What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?

What inhibits PDH activity in the heart?

How does inhibition of FA oxidation affect the uptake and oxidation of glucose and lactate in the heart?

What effect does a high rate of FA oxidation have on the mitochondria in terms of acetyl CoA and NADH levels?

How are FA and glucose utilization interrelated in the heart?

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