5 Questions
What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?
FA oxidation
What inhibits PDH activity in the heart?
High rate of FA oxidation
How does inhibition of FA oxidation affect the uptake and oxidation of glucose and lactate in the heart?
Increases uptake and oxidation of glucose and lactate
What effect does a high rate of FA oxidation have on the mitochondria in terms of acetyl CoA and NADH levels?
Increases acetyl CoA and NADH levels
How are FA and glucose utilization interrelated in the heart?
Tightly linked and co-regulated
This quiz explores the modulation of substrate selection and use in the heart, focusing on factors like allosteric regulation, hormonal influences like insulin and epinephrine, and the interplay between fatty acids (FA) and glucose utilization. It also discusses how FA oxidation acts as the primary physiological regulator of flux through pyruvate dehydrogenase (PDH) and glucose oxidation.
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