Substrate Selection and Regulation in the Heart
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Questions and Answers

What is the primary physiological regulator of flux through PDH and the rate of glucose oxidation in the heart?

  • Allosteric regulation
  • Epinephrine regulation
  • FA oxidation (correct)
  • Insulin regulation

    • What inhibits PDH activity in the heart?

  • Increased NADH levels
  • High rate of FA oxidation (correct)
  • Lack of insulin
  • Low levels of glucose

    • How does inhibition of FA oxidation affect the uptake and oxidation of glucose and lactate in the heart?

  • Promotes storage of glucose and lactate
  • Increases uptake and oxidation of glucose and lactate (correct)
  • Reduces uptake and oxidation of glucose and lactate
  • Has no effect on glucose and lactate metabolism

    • What effect does a high rate of FA oxidation have on the mitochondria in terms of acetyl CoA and NADH levels?

    <p>Increases acetyl CoA and NADH levels</p> Signup and view all the answers

    How are FA and glucose utilization interrelated in the heart?

    <p>Tightly linked and co-regulated</p> Signup and view all the answers

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