29 Questions
What is the haematopoietic function of the spleen?
Formation and maturation of red blood cells
What is the haemocatheretic function of the spleen responsible for?
Controlled destruction of blood cells
What are the major immune functions of the spleen as a secondary lymphoid organ?
Stimulation of B and T cells to give rise to humoral and cellular immune responses
What is the structure surrounding the spleen?
A capsule of dense connective tissue
Which cells make up the white splenic pulp?
T cells, interdigitating cells, and macrophages
What is the parenchyma of the spleen composed of?
White splenic pulp, red splenic pulp, and the marginal zone
What cells occupy the marginal zone of the spleen?
Specialized B cells and macrophages
What provides passage for arteries, veins, lymphatics, and nerves in the spleen?
Trabeculae
Which vessels collect capillary blood in the spleen?
Venous sinuses
What is the function of splenic cords in the spleen?
Filter blood and remove old erythrocytes
What is the composition of the reticular fibers in the spleen?
Argyrophilic reticular cells of stellate morphology
What is the main component of the red splenic pulp?
Red blood cells and platelets
Which structures form from branching of central arteries in the spleen?
Trabecular arteries and then periarterial lymphoid sheaths
What type of network do collagen fibers form in the spleen?
Three-dimensional network of reticular fibers
What are the primary components of the trabeculae in the spleen?
Fibroblasts, collagen fibers, elastic fibers, and smooth muscle fibers
What is the main function of the spleen as a secondary lymphoid organ?
Stimulation of B and T cells by antigens
What is the haematopoietic function of the spleen responsible for?
Production of leukocytes, erythrocytes, megakaryocytes, and platelets
Which part of the spleen serves as a blood filter, engulfing old or bad blood cells?
Spleen parenchyma
What is the structure surrounding the spleen that contains smooth muscle fibers and elastic networks?
Spleen capsule
What type of cells make up the periarterial lymphoid sheath in the white splenic pulp?
T cells and B cells
Which cells mainly constitute the lymphoid follicles in the white splenic pulp?
B cells and macrophages
What forms a three-dimensional network of reticular fibers in the spleen?
Collagen fibers of the trabeculae
What is the composition of the marginal zone in the spleen?
Macrophages and reticular cells
What are the dilated and tortuous ducts that collect capillary blood in the spleen known as?
Venous sinuses
What is the primary function of splenic cords in the spleen?
Filtering blood and removing old erythrocytes
Which vessels branch repeatedly to form periarterial lymphoid sheaths in the spleen?
Central arteries
What is lining the spleen capsule at the hilum?
Mesothelium
Which structures provide passage for arteries, veins, lymphatics, and nerves in the spleen?
Trabeculae
What do venous sinuses in the spleen surround?
Macrophages
Study Notes
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The spleen capsule is lined by a mesothelium and is thickened at the hilum, where it allows for arteries, nerves, veins, and lymphatic vessels to enter.
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Trabeculae, made up of fibroblasts, collagen fibers, elastic fibers, and smooth muscle fibers, start from the capsule and provide passage for arteries, veins, lymphatics, and nerves.
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Collagen fibers of the trabeculae continue into a three-dimensional network of reticular fibers that are argyrophilic and formed by reticular cells of stellate morphology.
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The spleen's parenchyma consists of three zones or compartments: white splenic pulp, red splenic pulp, and the marginal zone.
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White splenic pulp is made up of periarterial lymphoid sheaths and lymphoid follicles, surrounded by a network of reticular fibers and cells.
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T cells, interdigitating cells, and macrophages make up the periarterial lymphoid sheath, with lymphoid follicles mainly composed of B cells, follicular dendritic cells, and macrophages.
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Central arteries, muscular arteries that supply the lymphoid structures, branch repeatedly to form trabecular arteries and then periarterial lymphoid sheaths.
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Capillaries in the white splenic pulp receive blood from central and follicular arteries and are surrounded by splenic cords, which are mostly made up of macrophages.
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Venous sinuses, dilated and tortuous ducts, collect capillary blood and are surrounded by splenic cords, where macrophages filter blood and remove old erythrocytes.
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The marginal zone is a transition zone between the white and red splenic pulp, consisting of a framework of reticular fibers and cells, occupied by specialized B cells and macrophages.
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The anastomosis of capillaries with the venous system is a subject of controversy, with three theories suggesting either closed or open circulation.
-
The spleen capsule is lined by a mesothelium and is thickened at the hilum, where it allows for arteries, nerves, veins, and lymphatic vessels to enter.
-
Trabeculae, made up of fibroblasts, collagen fibers, elastic fibers, and smooth muscle fibers, start from the capsule and provide passage for arteries, veins, lymphatics, and nerves.
-
Collagen fibers of the trabeculae continue into a three-dimensional network of reticular fibers that are argyrophilic and formed by reticular cells of stellate morphology.
-
The spleen's parenchyma consists of three zones or compartments: white splenic pulp, red splenic pulp, and the marginal zone.
-
White splenic pulp is made up of periarterial lymphoid sheaths and lymphoid follicles, surrounded by a network of reticular fibers and cells.
-
T cells, interdigitating cells, and macrophages make up the periarterial lymphoid sheath, with lymphoid follicles mainly composed of B cells, follicular dendritic cells, and macrophages.
-
Central arteries, muscular arteries that supply the lymphoid structures, branch repeatedly to form trabecular arteries and then periarterial lymphoid sheaths.
-
Capillaries in the white splenic pulp receive blood from central and follicular arteries and are surrounded by splenic cords, which are mostly made up of macrophages.
-
Venous sinuses, dilated and tortuous ducts, collect capillary blood and are surrounded by splenic cords, where macrophages filter blood and remove old erythrocytes.
-
The marginal zone is a transition zone between the white and red splenic pulp, consisting of a framework of reticular fibers and cells, occupied by specialized B cells and macrophages.
-
The anastomosis of capillaries with the venous system is a subject of controversy, with three theories suggesting either closed or open circulation.
Test your knowledge about the functions of the spleen as a secondary lymphoid organ, including its role in haematopoiesis and haemocatheresis.
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