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Questions and Answers
Which type of polymorphism is characterized by the repetition of two or more nucleotides in multiple copies directly adjacent to one another in a DNA sequence?
Which type of polymorphism is characterized by the repetition of two or more nucleotides in multiple copies directly adjacent to one another in a DNA sequence?
- Single-nucleotide polymorphism (SNP)
- Short tandem repeat (STR) (correct)
- Insertion/deletion polymorphism
- Copy number variation
What is the typical length range of repeated sequences in short tandem repeats (STRs)?
What is the typical length range of repeated sequences in short tandem repeats (STRs)?
- 8 to 15 nucleotides
- 4 to 10 nucleotides
- 2 to 7 nucleotides (correct)
- 1 to 3 nucleotides
What is the frequency of each variation in a single-nucleotide polymorphism (SNP) within a population?
What is the frequency of each variation in a single-nucleotide polymorphism (SNP) within a population?
- Around 10%
- More than 90%
- Approximately 50%
- Less than 1% (correct)
Where are short tandem repeats (STRs) typically found in the genome?
Where are short tandem repeats (STRs) typically found in the genome?
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How are alleles of short tandem repeats (STRs) often characterized?
How are alleles of short tandem repeats (STRs) often characterized?
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Study Notes
Polymorphisms in DNA Sequences
- Microsatellites: characterized by the repetition of two or more nucleotides in multiple copies directly adjacent to one another in a DNA sequence.
Short Tandem Repeats (STRs)
- Length range: typically ranges from 2-10 nucleotides, with repeat units ranging from 5-100 copies.
- Genomic location: typically found in non-coding regions of the genome, such as introns, and intergenic regions.
- Allele characterization: alleles are often characterized by the number of repeat units present.
Single-Nucleotide Polymorphisms (SNPs)
- Frequency of variation: the frequency of each variation within a population is typically greater than 1%.
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