Podcast
Questions and Answers
Which of the following statements about polymorphism is correct?
Which of the following statements about polymorphism is correct?
- Polymorphism refers to a trait with a minor allele frequency of less than 1%.
- Polymorphism refers to a trait that can only be studied in DNA.
- Polymorphism refers to a trait controlled by a single locus with at least 2 alleles. (correct)
- Polymorphism refers to a trait that affects disease susceptibility and drug responses.
Which blood type is the most common worldwide?
Which blood type is the most common worldwide?
- Type O (correct)
- Type B
- Type A
- Type AB
How many alleles are there for the ABO gene?
How many alleles are there for the ABO gene?
- 1 allele
- 2 alleles
- 4 alleles
- 3 alleles (correct)
Which enzyme adds L-Fucose to the H precursor?
Which enzyme adds L-Fucose to the H precursor?
How many SNPs are involved in the formation of A and B blood groups?
How many SNPs are involved in the formation of A and B blood groups?
What is the consequence of the 1 base deletion at cDNA 261 (G) in the cDNA for O type?
What is the consequence of the 1 base deletion at cDNA 261 (G) in the cDNA for O type?
What is the role of RFLPs in DNA analysis?
What is the role of RFLPs in DNA analysis?
Which of the following is true about polymorphisms in genetic variation?
Which of the following is true about polymorphisms in genetic variation?
Which of the following is NOT true about ABO blood groups?
Which of the following is NOT true about ABO blood groups?
How many alleles are there for the ABO gene?
How many alleles are there for the ABO gene?
Which of the following is true about the ABO gene and its alleles?
Which of the following is true about the ABO gene and its alleles?
Which of the following is true about the H antigen?
Which of the following is true about the H antigen?
How are VNTRs used in DNA analysis?
How are VNTRs used in DNA analysis?
What is the role of restriction enzymes in RFLP analysis?
What is the role of restriction enzymes in RFLP analysis?
Study Notes
Polymorphism and ABO Blood Groups
- Polymorphism refers to the existence of multiple forms of a gene or protein, leading to variations in a population.
ABO Blood Groups
- The most common blood type worldwide is Type O.
- The ABO gene has three alleles: A, B, and O.
- There are four possible blood groups: A, B, AB, and O.
Formation of A and B Blood Groups
- Two SNPs (single nucleotide polymorphisms) are involved in the formation of A and B blood groups.
H Antigen and Fucose
- The H antigen is the precursor to the A and B antigens.
- The enzyme responsible for adding L-Fucose to the H precursor is Fucosyltransferase.
Consequences of Genetic Mutations
- A 1-base deletion at cDNA 261 (G) in the cDNA for O type leads to the loss of enzyme activity, resulting in the O blood type.
RFLP Analysis and DNA Variation
- RFLPs (restriction fragment length polymorphisms) are used in DNA analysis to identify genetic variations.
- RFLPs involve the use of restriction enzymes to cut DNA at specific sites, resulting in distinct fragments that can be analyzed.
- The role of restriction enzymes in RFLP analysis is to cut DNA at specific sites, allowing for the identification of genetic variations.
VNTRs in DNA Analysis
- VNTRs (variable number tandem repeats) are used in DNA analysis to identify genetic variations.
- VNTRs involve the analysis of repeated DNA sequences that vary in length between individuals.
Genetic Variation and Polymorphisms
- Polymorphisms in genetic variation refer to the existence of multiple forms of a gene or protein, leading to variations in a population.
- Genetic polymorphisms can result in differences in blood types, susceptibility to diseases, and response to medications.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Genetics Lecture 7
