Skin Structure and Function Quiz

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Questions and Answers

What is primarily found in the hypodermis/subcutis layer?

  • Gray adipose tissue
  • Nervous tissue
  • Dense connective tissue
  • White adipose tissue (correct)

What do fibrous septae in the hypodermis do?

  • Enhance pain sensitivity
  • Connect skin to muscles
  • Regulate skin pigmentation
  • Aid in the division of fat into lobules (correct)

How are burns classified under the current medical terminology?

  • Minor, moderate, and severe
  • Full thickness and partial thickness (correct)
  • First, second, and third degree
  • Surface and deep burns

Which statement is true regarding treatment for burns?

<p>Full thickness burns generally require grafting for treatment. (C)</p> Signup and view all the answers

In what condition may hospitalization be required for burn treatment?

<p>For burns located on specific areas of the body (B)</p> Signup and view all the answers

Which layer of the epidermis is primarily responsible for creating an impermeable barrier between cells?

<p>Stratum granulosum (A)</p> Signup and view all the answers

What term describes the process of keratinocytes changing shape and structural features as they move up through the epidermis?

<p>Cytomorphosis (B)</p> Signup and view all the answers

Which cells in the epidermis are primarily responsible for the formation of melanin?

<p>Melanocytes (B)</p> Signup and view all the answers

In which layer of the skin would you find mitotically active keratinocytes that are connected by desmosomes?

<p>Stratum spinosum (A)</p> Signup and view all the answers

Which layer of the epidermis is considered the cornified layer that consists of dead, flattened keratinocytes?

<p>Stratum corneum (C)</p> Signup and view all the answers

Which layer of skin is specifically found only in thick skin, such as on the palms and soles?

<p>Stratum lucidum (D)</p> Signup and view all the answers

What substance do the granules in the stratum granulosum contribute to the process of keratinization?

<p>Keratohyalin (D)</p> Signup and view all the answers

Which of the following functions is NOT attributed to the skin?

<p>Regulating blood sugar levels (C)</p> Signup and view all the answers

Which layer of the dermis contains the majority of sweat glands and hair follicles?

<p>Reticular dermis (C)</p> Signup and view all the answers

What is the mechanism through which sebaceous glands secrete their product?

<p>Holocrine (D)</p> Signup and view all the answers

Which type of receptor is primarily responsible for detecting light touch in the skin?

<p>Merkel cells (B)</p> Signup and view all the answers

What type of connective tissue is the papillary dermis composed of?

<p>Loose connective tissue (A)</p> Signup and view all the answers

Which type of gland is primarily involved in thermoregulation through sweating?

<p>Eccrine glands (D)</p> Signup and view all the answers

Which cells act as antigen-presenting cells within the skin?

<p>Langerhans cells (B)</p> Signup and view all the answers

Which component of the dermis contributes to its eosinophilic appearance in H&E stains?

<p>Collagen fibers (D)</p> Signup and view all the answers

What stimulates the production of melanin in melanocytes?

<p>Melanocyte stimulating hormone (MSH) (A)</p> Signup and view all the answers

What structure does the arrector pili muscle associate with?

<p>Hair follicles (A)</p> Signup and view all the answers

Where are eccrine sweat glands primarily found?

<p>Throughout the body (A)</p> Signup and view all the answers

Which of the following is not true regarding the papillary dermis?

<p>It is composed of dense irregular connective tissue (B)</p> Signup and view all the answers

What is the primary role of keratinocytes in the skin?

<p>Production of keratin (D)</p> Signup and view all the answers

What aspect of skin appendages is true regarding nails?

<p>The nail grows from the nail bed underneath (D)</p> Signup and view all the answers

Which type of sweat gland is found largely in specific regions such as the armpits and genitals?

<p>Apocrine glands (B)</p> Signup and view all the answers

Flashcards

Hypodermis/Subcutis

The deepest layer of skin, primarily composed of fat cells (adipose tissue) that provide insulation and cushioning.

Fibrous Septae

Strong fibrous connective tissue that divides the fat into compartments within the hypodermis.

Skin Mobility

Ability of the skin to move freely over underlying tissues due to the presence of the hypodermis.

Superficial Burns

Burns affecting only the top layer of skin (epidermis).

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Full Thickness Burns

Burns affecting both the epidermis and dermis, requiring skin grafts for healing.

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Stratum corneum

The outermost layer of the skin, composed of dead, flattened cells filled with keratin. This layer continually sheds and flakes off.

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Stratum lucidum

A thin layer found only in thick skin, such as the palms and soles. These cells lack nuclei and organelles and are densely packed with keratin.

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Stratum granulosum

A layer with 3-5 layers of cells, containing granules of keratohyalin and membrane-coating granules. These cells undergo apoptosis and become impermeable.

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Stratum spinosum

The thickest layer of the epidermis, with mitotically active cells connected by desmosomes, making it look prickly. It contains Langerhans cells and produces cytokeratin.

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Stratum basale

The innermost layer of the epidermis, a single layer of cuboidal cells actively dividing. It connects to the dermis and contains melanocytes and Merkel cells.

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Cytomorphosis

The process of keratinocyte maturation and differentiation, where cells change their shape and structure as they move through the epidermis.

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Melanocytes

Special cells in the epidermis that produce melanin, a pigment that gives skin its color and protects from UV light.

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Merkel cells

Cells in the stratum basale that function as mechanoreceptors, sensing touch and pressure.

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Papillary Dermis

The superficial layer of the dermis, characterized by loose connective tissue with projections called dermal ridges that interlock with the epidermis. It houses capillaries, mechanoreceptors and pain receptors.

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Reticular Dermis

The deeper layer of the dermis, composed of dense irregular connective tissue rich in collagen fibers. It anchors skin appendages, houses other mechanoreceptors, and contains smooth muscle.

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Keratinocytes

Specialized cells in the epidermis responsible for producing keratin, a protein that gives skin its strength and resilience.

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Langerhans Cells

Dendritic cells in the stratum spinosum of the epidermis, acting as antigen-presenting cells, crucial for immune responses in the skin.

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Holocrine Secretion

The mechanism by which sebaceous glands release their oily sebum, involving the disintegration of the entire cell as the secretory product.

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Nail Plate

The compact, keratinised epithelial cells forming the visible part of the nail, resting on the nail bed.

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Nail Bed

The epidermis beneath the nail plate, providing support and a base for nail growth.

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Eponychium

The proximal fold of epidermis surrounding the nail, often referred to as the cuticle.

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Hyponychium

The distal fold of epidermis surrounding the nail, protecting the nail from damage.

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Hair Follicles

The organs from which hairs develop, found within the dermis.

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Sebum

A mixture of oily substances, primarily cholesterol and triglycerides, secreted by sebaceous glands to lubricate and protect the skin and hair.

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Eccrine Sweat Glands

Specialized sweat glands found throughout the skin, releasing watery sweat directly onto the skin surface, playing a role in thermoregulation.

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Apocrine Sweat Glands

Sweat glands mainly located in the genital, axillary, and areola regions, producing a more odorous sweat, previously believed to be apocrine secretion but now considered merocrine.

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Study Notes

Skin Structure and Function

  • Skin functions as a protective barrier, regulates temperature, provides sensory input, excretes toxins, absorbs UV light for Vitamin D synthesis, and indicates health status.

Epidermis

  • Composed primarily of keratinocytes, arranged in stratified layers.
  • Keratinocytes undergo mitosis and differentiation (cytomorphosis) creating 5 distinct layers:
    • Stratum corneum: outermost layer of dead, flattened keratinocytes, constantly shedding.
    • Stratum lucidum: present only in thick skin (e.g., palms, soles), also dead keratinocytes.
    • Stratum granulosum: 3-5 layers of keratinocytes, nuclei and organelles disintegrate. Contains keratohyalin and membrane-coating granules forming an impermeable barrier.
    • Stratum spinosum: thickest layer with dividing keratinocytes connected by desmosomes. Contains Langerhans cells.
    • Stratum basale: single layer of cuboidal, dividing keratinocytes; connected to dermis. Contains melanocytes and Merkel cells.

Dermis

  • Connective tissue layer beneath the epidermis, separated by a basement membrane.
  • Divided into two layers:
    • Papillary dermis: loose connective tissue, dermal ridges, capillaries, nerve endings (e.g., Meissner corpuscles, Krause end bulbs, pain receptors).
    • Reticular dermis: dense irregular connective tissue, thick collagen fibers, sweat glands, sebaceous glands, hair follicles, nerve endings (e.g., Pacinian corpuscles, Ruffini corpuscles, Krause end bulbs, smooth muscle cells - arrector pili muscles).

Neurovascular Supply of the Dermis

  • Rich supply of nerves (encapsulated and free nerve endings), responsible for sensation.

Skin Cells

  • Keratinocytes: Produce keratin. Found throughout all epidermis layers.
  • Langerhans cells: Antigen-presenting cells; found in stratum spinosum.
  • Merkel cells: Mechanoreceptors; found in stratum basale.
  • Melanocytes: Produce melanin; found in stratum basale, responsible for protection from UV radiation by transferring melanin to surrounding keratinocytes.

Skin Appendages (Adnexal Structures)

  • Nails: Keratinized epithelial plate on nail bed, with eponychium and hyponychium.
  • Hair follicles: Structures from which hair develops, keratinized filaments projecting from skin surface.
  • Sebaceous glands: secrete sebum (oily mixture of cholesterol and triglycerides) into hair follicles, using a holocrine mechanism. Active after puberty, controlled by sex hormones.
  • Sweat glands:
    • Eccrine: release sweat directly onto skin surface (merocrine), involved in thermoregulation. Found throughout skin.
    • Apocrine: secrete sweat into hair follicles (thought to use a merocrine mechanism), more odorous. Found in specific locations like genitals and axillae.

Hypodermis/Subcutis

  • Primarily composed of adipose tissue (subcutaneous fat).
  • Provides skin mobility and insulation. Also connected to underlying tissues via fibrous septa.

Burns

  • Classification of burns is based on depth of injury rather than individual layer designation.
  • Full-thickness burns affecting all skin layers require grafts for healing.
  • Treatment depends on severity and location.

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