Skin Drug Delivery Dosage Forms Quiz
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Questions and Answers

Which type of dosage form is designed to remain in the skin?

  • Topical antibiotics (correct)
  • Insect repellents
  • Sunscreens
  • Transdermal corticosteroids
  • What is a benefit of transdermal drug delivery?

  • Decreased drug permeability through the skin
  • Reduced side effects associated with systemic toxicity (correct)
  • Limited patient acceptance and compliance
  • Increased first pass metabolism
  • Which type of dosage form is suitable for avoiding first pass metabolism?

  • Oral analgesics
  • Insect repellents
  • Transdermal nicotine replacement therapy (correct)
  • Topical antibiotics
  • What property is essential for a molecule to be suitable for transdermal drug delivery?

    <p>Molecular weight less than 500 Da</p> Signup and view all the answers

    What type of drug delivery provides direct access to the target or diseased site?

    <p>Transdermal drug delivery</p> Signup and view all the answers

    What is one advantage of topical drug delivery over systemic drug administration?

    <p>Localized treatment with reduced systemic side effects</p> Signup and view all the answers

    What are the common skin disorders mentioned in the text?

    <p>Psoriasis, eczema, and fungal skin disorders</p> Signup and view all the answers

    What is a limitation of transdermal drug delivery for very potent drugs?

    <p>It requires high concentrations in the blood</p> Signup and view all the answers

    Which layer of the skin is involved in the partitioning and release of drugs in transdermal drug delivery?

    <p>Stratum corneum</p> Signup and view all the answers

    What does Fick's law describe in the context of skin permeability?

    <p>Diffusion of drugs through the skin</p> Signup and view all the answers

    Which factor influences the penetration rate of a drug into the skin?

    <p>Concentration of dissolved drug</p> Signup and view all the answers

    Which factor is a drug physicochemical property that affects transdermal transport and bioavailability?

    <p>(Log p) Partition coefficient</p> Signup and view all the answers

    What does the term 'lag time' refer to in the context of skin permeability?

    <p>The time required to reach steady state</p> Signup and view all the answers

    What is the purpose of minimizing peaks and troughs in blood-drug levels?

    <p>To maintain a more constant therapeutic effect</p> Signup and view all the answers

    What is a physiological factor that can affect transdermal transport and bioavailability?

    <p>Regional variation (body site)</p> Signup and view all the answers

    What is the maximum amount of dry flavoring agents recommended for use in chewable tablets?

    <p>0.5-0.75%</p> Signup and view all the answers

    Which sweetening agent is known to be sweeter than sucrose but may leave a bitter aftertaste and is considered carcinogenic?

    <p>Saccharin</p> Signup and view all the answers

    What are adsorbents used for in the production of tablets?

    <p>To convert oily or liquid-soluble drugs into a dry state for compression into tablets</p> Signup and view all the answers

    Which polymers are commonly used in tablets to retard dissolution for controlled release?

    <p>Ethyl cellulose, carboxymethylcellulose, cellulose acetate phthalate</p> Signup and view all the answers

    Which type of agents are used in tablets containing poorly soluble drugs to enhance dissolution?

    <p>Wetting agents</p> Signup and view all the answers

    What is the first step in the wet granulation process for tablet manufacture?

    <p>Sieving the active ingredients and excipients</p> Signup and view all the answers

    What is the primary purpose of wetting agents in tablets?

    <p>To enhance dissolution of poorly soluble drugs</p> Signup and view all the answers

    In which process route for tablet manufacture is direct compression suitable?

    <p>Dry method process</p> Signup and view all the answers

    What is the purpose of adding a disintegrant in the dry granulation process?

    <p>To give a more rapid initial disintegration</p> Signup and view all the answers

    Which component is typically added to provide flowability and cohesive features to the powder mixture in direct compression?

    <p>Spray-dried lactose</p> Signup and view all the answers

    What is the method of choice for powder moisture or thermosensitive ingredients in tablet manufacture?

    <p>Dry granulation</p> Signup and view all the answers

    At which step in the direct compression process does the powder mixture need to be uniformized?

    <p>Before precompression (first step)</p> Signup and view all the answers

    What is the purpose of adding a lubricant in the dry granulation process?

    <p>To prevent sticking of granules during compression</p> Signup and view all the answers

    When does slugging occur in the dry granulation procedure?

    <p>Before initial mixing of ingredients</p> Signup and view all the answers

    What is the required particle size for granules before they are compressed in wet granulation?

    <p>Coarse</p> Signup and view all the answers

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