Skin Drug Delivery Dosage Forms Quiz

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Which type of dosage form is designed to remain in the skin?

Topical antibiotics

What is a benefit of transdermal drug delivery?

Reduced side effects associated with systemic toxicity

Which type of dosage form is suitable for avoiding first pass metabolism?

Transdermal nicotine replacement therapy

What property is essential for a molecule to be suitable for transdermal drug delivery?

<p>Molecular weight less than 500 Da</p> Signup and view all the answers

What type of drug delivery provides direct access to the target or diseased site?

<p>Transdermal drug delivery</p> Signup and view all the answers

What is one advantage of topical drug delivery over systemic drug administration?

<p>Localized treatment with reduced systemic side effects</p> Signup and view all the answers

What are the common skin disorders mentioned in the text?

<p>Psoriasis, eczema, and fungal skin disorders</p> Signup and view all the answers

What is a limitation of transdermal drug delivery for very potent drugs?

<p>It requires high concentrations in the blood</p> Signup and view all the answers

Which layer of the skin is involved in the partitioning and release of drugs in transdermal drug delivery?

<p>Stratum corneum</p> Signup and view all the answers

What does Fick's law describe in the context of skin permeability?

<p>Diffusion of drugs through the skin</p> Signup and view all the answers

Which factor influences the penetration rate of a drug into the skin?

<p>Concentration of dissolved drug</p> Signup and view all the answers

Which factor is a drug physicochemical property that affects transdermal transport and bioavailability?

<p>(Log p) Partition coefficient</p> Signup and view all the answers

What does the term 'lag time' refer to in the context of skin permeability?

<p>The time required to reach steady state</p> Signup and view all the answers

What is the purpose of minimizing peaks and troughs in blood-drug levels?

<p>To maintain a more constant therapeutic effect</p> Signup and view all the answers

What is a physiological factor that can affect transdermal transport and bioavailability?

<p>Regional variation (body site)</p> Signup and view all the answers

What is the maximum amount of dry flavoring agents recommended for use in chewable tablets?

<p>0.5-0.75%</p> Signup and view all the answers

Which sweetening agent is known to be sweeter than sucrose but may leave a bitter aftertaste and is considered carcinogenic?

<p>Saccharin</p> Signup and view all the answers

What are adsorbents used for in the production of tablets?

<p>To convert oily or liquid-soluble drugs into a dry state for compression into tablets</p> Signup and view all the answers

Which polymers are commonly used in tablets to retard dissolution for controlled release?

<p>Ethyl cellulose, carboxymethylcellulose, cellulose acetate phthalate</p> Signup and view all the answers

Which type of agents are used in tablets containing poorly soluble drugs to enhance dissolution?

<p>Wetting agents</p> Signup and view all the answers

What is the first step in the wet granulation process for tablet manufacture?

<p>Sieving the active ingredients and excipients</p> Signup and view all the answers

What is the primary purpose of wetting agents in tablets?

<p>To enhance dissolution of poorly soluble drugs</p> Signup and view all the answers

In which process route for tablet manufacture is direct compression suitable?

<p>Dry method process</p> Signup and view all the answers

What is the purpose of adding a disintegrant in the dry granulation process?

<p>To give a more rapid initial disintegration</p> Signup and view all the answers

Which component is typically added to provide flowability and cohesive features to the powder mixture in direct compression?

<p>Spray-dried lactose</p> Signup and view all the answers

What is the method of choice for powder moisture or thermosensitive ingredients in tablet manufacture?

<p>Dry granulation</p> Signup and view all the answers

At which step in the direct compression process does the powder mixture need to be uniformized?

<p>Before precompression (first step)</p> Signup and view all the answers

What is the purpose of adding a lubricant in the dry granulation process?

<p>To prevent sticking of granules during compression</p> Signup and view all the answers

When does slugging occur in the dry granulation procedure?

<p>Before initial mixing of ingredients</p> Signup and view all the answers

What is the required particle size for granules before they are compressed in wet granulation?

<p>Coarse</p> Signup and view all the answers

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