Transdermal Drug Delivery Systems: Introduction and Classification
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Questions and Answers

What is the primary purpose of a transdermal drug delivery system?

  • To deliver drugs directly into the stomach
  • To deliver drugs through the respiratory system
  • To deliver drugs through intramuscular injection
  • To deliver drugs for systemic effects at a predetermined and controlled rate (correct)

    • What is a key advantage of transdermal drug delivery systems?

  • Avoidance of first-pass effect (correct)
  • Rapid onset of action
  • Direct delivery into the bloodstream
  • High absorption efficiency at different sites of the skin

    • What is a common disadvantage of transdermal drug delivery systems?

  • Non-irritating to the skin
  • Low drug load requirement
  • Rapid diffusion of large molecules
  • Skin irritation (correct)

    • Why are transdermal drug delivery systems unsuitable for large drug doses?

    <p>They may cause poor diffusion of large molecules and skin irritation</p> Signup and view all the answers

    Which characteristic makes a drug suitable for administration via a transdermal patch?

    <p>Short half-life and narrow therapeutic window</p> Signup and view all the answers

    What type of drugs are suitable for delivery through transdermal drug delivery systems?

    <p>Drugs with poor oral availability and narrow therapeutic window</p> Signup and view all the answers

    What is the main function of the stratum granulosum?

    <p>To make the skin water-repellent</p> Signup and view all the answers

    Which layer of the skin consists of 25 to 30 layers of flattened dead keratinocytes?

    <p>Stratum corneum</p> Signup and view all the answers

    What is the function of Merkel cells in the epidermis?

    <p>To act as sensory receptors for light touch</p> Signup and view all the answers

    What is the role of Langerhans cells in the stratum spinosum?

    <p>To present antigens to the immune system</p> Signup and view all the answers

    Which layer of the skin contains cells that are dividing?

    <p>Stratum basale</p> Signup and view all the answers

    What is the function of stratum spinosum in the epidermis?

    <p>To provide strength to the epidermis</p> Signup and view all the answers

    What type of cells produce melanin in the skin?

    <p>Melanocytes</p> Signup and view all the answers

    In which layer do cells start losing their nuclei and undergo keratinization?

    <p>Stratum basale</p> Signup and view all the answers

    What is the main function of Stratum Spinosum in the skin?

    <p>To provide strength to the epidermis.</p> Signup and view all the answers

    What is a common disadvantage of transdermal drug delivery systems?

    <p>Poor diffusion of large molecules</p> Signup and view all the answers

    What is the primary concern regarding the absorption efficiency of transdermal drug delivery systems?

    <p>Inconsistent absorption efficiency at different skin sites</p> Signup and view all the answers

    Why are transdermal drug delivery systems unsuitable for large drug doses?

    <p>Poor diffusion of large molecules</p> Signup and view all the answers

    Why might skin irritation be a concern with transdermal drug delivery systems?

    <p>Skin irritation</p> Signup and view all the answers

    What is a significant disadvantage of transdermal drug delivery systems?

    <p>Poor diffusion of large molecules</p> Signup and view all the answers

    Why are transdermal drug delivery systems unsuitable for large drug doses?

    <p>Inadequate diffusion for large molecules</p> Signup and view all the answers

    What factor causes variability in the absorption efficiency of transdermal drug delivery systems across different skin sites?

    <p>Age-related changes in the skin</p> Signup and view all the answers

    What is a common challenge associated with the use of transdermal drug delivery systems?

    <p>High drug load requirement</p> Signup and view all the answers

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