23 Questions
What is the primary purpose of a transdermal drug delivery system?
To deliver drugs for systemic effects at a predetermined and controlled rate
What is a key advantage of transdermal drug delivery systems?
Avoidance of first-pass effect
What is a common disadvantage of transdermal drug delivery systems?
Skin irritation
Why are transdermal drug delivery systems unsuitable for large drug doses?
They may cause poor diffusion of large molecules and skin irritation
Which characteristic makes a drug suitable for administration via a transdermal patch?
Short half-life and narrow therapeutic window
What type of drugs are suitable for delivery through transdermal drug delivery systems?
Drugs with poor oral availability and narrow therapeutic window
What is the main function of the stratum granulosum?
To make the skin water-repellent
Which layer of the skin consists of 25 to 30 layers of flattened dead keratinocytes?
Stratum corneum
What is the function of Merkel cells in the epidermis?
To act as sensory receptors for light touch
What is the role of Langerhans cells in the stratum spinosum?
To present antigens to the immune system
Which layer of the skin contains cells that are dividing?
Stratum basale
What is the function of stratum spinosum in the epidermis?
To provide strength to the epidermis
What type of cells produce melanin in the skin?
Melanocytes
In which layer do cells start losing their nuclei and undergo keratinization?
Stratum basale
What is the main function of Stratum Spinosum in the skin?
To provide strength to the epidermis.
What is a common disadvantage of transdermal drug delivery systems?
Poor diffusion of large molecules
What is the primary concern regarding the absorption efficiency of transdermal drug delivery systems?
Inconsistent absorption efficiency at different skin sites
Why are transdermal drug delivery systems unsuitable for large drug doses?
Poor diffusion of large molecules
Why might skin irritation be a concern with transdermal drug delivery systems?
Skin irritation
What is a significant disadvantage of transdermal drug delivery systems?
Poor diffusion of large molecules
Why are transdermal drug delivery systems unsuitable for large drug doses?
Inadequate diffusion for large molecules
What factor causes variability in the absorption efficiency of transdermal drug delivery systems across different skin sites?
Age-related changes in the skin
What is a common challenge associated with the use of transdermal drug delivery systems?
High drug load requirement
Explore the introduction, advantages, disadvantages, and comparisons of transdermal drug delivery systems (TDDS) with intravenous and oral administration. Learn about the anatomy and physiology of the skin, permeation of drug molecules through the skin, percutaneous absorption, and the basic components and factors affecting transdermal permeation. Discover the classification, evaluation, and application of TDDS, along with the market products and references.
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