Transdermal Drug Delivery Systems: Introduction and Classification

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Questions and Answers

What is the primary purpose of a transdermal drug delivery system?

  • To deliver drugs directly into the stomach
  • To deliver drugs through the respiratory system
  • To deliver drugs through intramuscular injection
  • To deliver drugs for systemic effects at a predetermined and controlled rate (correct)

What is a key advantage of transdermal drug delivery systems?

  • Avoidance of first-pass effect (correct)
  • Rapid onset of action
  • Direct delivery into the bloodstream
  • High absorption efficiency at different sites of the skin

What is a common disadvantage of transdermal drug delivery systems?

  • Non-irritating to the skin
  • Low drug load requirement
  • Rapid diffusion of large molecules
  • Skin irritation (correct)

Why are transdermal drug delivery systems unsuitable for large drug doses?

<p>They may cause poor diffusion of large molecules and skin irritation (C)</p> Signup and view all the answers

Which characteristic makes a drug suitable for administration via a transdermal patch?

<p>Short half-life and narrow therapeutic window (D)</p> Signup and view all the answers

What type of drugs are suitable for delivery through transdermal drug delivery systems?

<p>Drugs with poor oral availability and narrow therapeutic window (A)</p> Signup and view all the answers

What is the main function of the stratum granulosum?

<p>To make the skin water-repellent (B)</p> Signup and view all the answers

Which layer of the skin consists of 25 to 30 layers of flattened dead keratinocytes?

<p>Stratum corneum (A)</p> Signup and view all the answers

What is the function of Merkel cells in the epidermis?

<p>To act as sensory receptors for light touch (A)</p> Signup and view all the answers

What is the role of Langerhans cells in the stratum spinosum?

<p>To present antigens to the immune system (A)</p> Signup and view all the answers

Which layer of the skin contains cells that are dividing?

<p>Stratum basale (A)</p> Signup and view all the answers

What is the function of stratum spinosum in the epidermis?

<p>To provide strength to the epidermis (D)</p> Signup and view all the answers

What type of cells produce melanin in the skin?

<p>Melanocytes (B)</p> Signup and view all the answers

In which layer do cells start losing their nuclei and undergo keratinization?

<p>Stratum basale (C)</p> Signup and view all the answers

What is the main function of Stratum Spinosum in the skin?

<p>To provide strength to the epidermis. (A)</p> Signup and view all the answers

What is a common disadvantage of transdermal drug delivery systems?

<p>Poor diffusion of large molecules (D)</p> Signup and view all the answers

What is the primary concern regarding the absorption efficiency of transdermal drug delivery systems?

<p>Inconsistent absorption efficiency at different skin sites (D)</p> Signup and view all the answers

Why are transdermal drug delivery systems unsuitable for large drug doses?

<p>Poor diffusion of large molecules (B)</p> Signup and view all the answers

Why might skin irritation be a concern with transdermal drug delivery systems?

<p>Skin irritation (C)</p> Signup and view all the answers

What is a significant disadvantage of transdermal drug delivery systems?

<p>Poor diffusion of large molecules (D)</p> Signup and view all the answers

Why are transdermal drug delivery systems unsuitable for large drug doses?

<p>Inadequate diffusion for large molecules (B)</p> Signup and view all the answers

What factor causes variability in the absorption efficiency of transdermal drug delivery systems across different skin sites?

<p>Age-related changes in the skin (B)</p> Signup and view all the answers

What is a common challenge associated with the use of transdermal drug delivery systems?

<p>High drug load requirement (C)</p> Signup and view all the answers

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