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Sildenafil
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Sildenafil

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What is the primary reason for seeking more chemically stable prostacyclin mimics?

  • To enhance the oral bioavailability of prostacyclin
  • To overcome the short half-life of prostacyclin (correct)
  • To reduce the side effects of prostacyclin
  • To increase the local action of prostacyclin

    • Which condition is soluble guanylate cyclase stimulators (SGCs) used to treat?

  • Asthma
  • Coronary artery disease
  • Chronic obstructive pulmonary disease
  • Pulmonary arterial hypertension (correct)

    • How do soluble guanylate cyclase stimulators (SGCs) work?

  • By inhibiting the activity of sGC
  • By enhancing the activity of sGC and its sensitivity to nitric oxide (correct)
  • By directly relaxing vascular smooth muscles
  • By increasing the production of nitric oxide

    • What is the initial dosage form for prostacyclin receptor agonist (PRA) in treating PAH?

    <p>Oral dosage form (tablets)</p> Signup and view all the answers

    What is the maximum recommended dosage for soluble guanylate cyclase stimulators (SGCs) in treating chronic heart failure?

    <p>10 mg once a day</p> Signup and view all the answers

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