Sepsis Overview and Mechanisms
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Questions and Answers

Which of the following correctly describes the mechanism by which sepsis leads to decreased oxygen delivery to organs?

  • Decreased cardiac output due to a combination of dilated blood vessels and increased vascular permeability. (correct)
  • Reduced oxygen carrying capacity of blood due to the formation of microclots in the capillaries.
  • Increased red blood cell destruction due to disseminated intravascular coagulation (DIC).
  • Increased systemic vascular resistance due to vasoconstriction.
  • Which of the following is a direct consequence of the increased permeability of blood vessels during sepsis?

  • Increased production of systemic cytokines.
  • Development of disseminated intravascular coagulation (DIC).
  • Formation of microclots in the capillaries. (correct)
  • Increased metabolic acidosis.
  • Which of the following best explains the link between sepsis and the development of metabolic acidosis?

  • Accumulation of lactic acid as a byproduct of anaerobic metabolism in oxygen-deprived tissues. (correct)
  • Increased production of ketones by the liver in response to low blood sugar.
  • Reduced oxygen delivery to tissues due to microclot formation and decreased cardiac output.
  • Decreased bicarbonate production by the kidneys due to organ dysfunction.
  • Which of the following accurately describes the role of disseminated intravascular coagulation (DIC) in sepsis?

    <p>DIC contributes to the formation of microclots that further impair oxygen delivery. (D)</p> Signup and view all the answers

    Which of the following best explains the clinical presentation of increased respiratory rate (tachypnea) and accessory muscle use in sepsis?

    <p>Metabolic acidosis stimulating increased respiratory effort to expel carbon dioxide. (D)</p> Signup and view all the answers

    A patient presents with a pH of 7.32, PaCO2 of 48 mmHg, and HCO3 of 25 mEq/L. What is the most likely interpretation of these findings?

    <p>Respiratory acidosis with metabolic compensation (B)</p> Signup and view all the answers

    A patient with a history of chronic obstructive pulmonary disease (COPD) is found to have a PaCO2 of 60 mmHg. Which of the following is most likely to be the patient's pH?

    <p>7.20 (A)</p> Signup and view all the answers

    A patient presents with severe diarrhea resulting in excessive bicarbonate loss. Which of the following changes in blood gas parameters would you expect to see?

    <p>Decreased PaCO2 and decreased pH (B)</p> Signup and view all the answers

    A patient with a history of hyperventilation is found to have a PaCO2 of 28 mmHg. Which of the following mechanisms is most likely responsible for this finding?

    <p>Increased respiratory rate (C)</p> Signup and view all the answers

    Which of the following scenarios would most likely result in an increased pH and a decreased PaCO2?

    <p>Severe vomiting with loss of stomach acid (B)</p> Signup and view all the answers

    A patient with a pH of 7.50 and a HCO3 of 32 mEq/L is most likely experiencing which of the following conditions?

    <p>Metabolic alkalosis (B)</p> Signup and view all the answers

    Which of the following interpretations is incorrect regarding the relationship between pH and PaCO2 in respiratory compensation for metabolic acidosis?

    <p>The change in PaCO2 is in the same direction as the change in pH (C)</p> Signup and view all the answers

    A patient with a history of asthma is experiencing an acute asthma exacerbation. Would you expect to see a decrease in PaCO2, an increase in PaCO2, or no change in PaCO2?

    <p>Decrease in PaCO2 (D)</p> Signup and view all the answers

    Flashcards

    Sepsis

    A severe reaction to infection causing systemic inflammation.

    Immunologic overactivity

    An exaggerated immune response to infection leading to harmful effects.

    Cytokines

    Proteins released during inflammation that trigger immune responses.

    Disseminated intravascular coagulopathy (DIC)

    A serious condition causing abnormal clotting and bleeding in the body.

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    Metabolic acidosis

    An imbalance in the body's acid-base status, often leading to organ failure.

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    ABG Normal Values

    Normal arterial blood gas values: pH 7.35-7.45, HCO3 21-28 mEq/L, PaCO2 35-45 mmHg, PaO2 80-100 mmHg, SaO2 >95%.

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    Lactic Acid

    Lactic acid results from anaerobic respiration, leading to metabolic acidosis.

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    Respiratory Compensation

    Increased breathing due to high CO2 to correct low pH.

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    Respiratory Issues

    Conditions leading to pH increase and PaCO2 decrease (opposite relationship).

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    Metabolic Issues

    Conditions causing both pH and HCO3 to increase (same direction).

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    Acidosis

    Condition indicated by pH < 7.35, when acid increases.

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    Alkalosis

    Condition indicated by pH > 7.45, when alkalinity increases.

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    ABG Interpretation Rule

    For ABG results: Respiratory Opposite, Metabolic Equal.

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    Study Notes

    Sepsis Summary

    • Infection triggers reaction.
    • Triggers immunologic overactivity.
    • Hyperactive response + white blood cells.
    • Systemic cytokines released.
    • Dilated blood vessels + permeability.
    • SpO2 ↓ HR ↑ BP ↓
    • Rash /Edema.
    • Lowers SV, HR ↑ + low O2 to organs.
    • Respiratory ↑ acidosis.
    • Accessory muscle use.
    • Triggers disseminated intravascular coagulopathy.
    • Leads to metabolic acidosis → Multiple organ failure → even less O2.

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    Description

    This quiz provides a comprehensive overview of sepsis, detailing the body's immunologic response to infection. It covers the systemic effects of sepsis, including changes in blood chemistry and organ function, and the potential progression to multiple organ failure. Test your understanding of these key concepts related to sepsis.

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