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Questions and Answers
What is the primary trigger for sepsis?
What is the primary trigger for sepsis?
- A genetic predisposition to immune overactivity
- An existing infection (correct)
- Exposure to environmental toxins
- A sudden drop in blood pressure
What is the body's initial response to an infection that can lead to sepsis?
What is the body's initial response to an infection that can lead to sepsis?
- A localized immunologic reaction
- An immunologic overactivity (correct)
- A decrease in leukocyte count
- Hypoactive immune response
What is the direct result of excess leukocytes in the context of sepsis?
What is the direct result of excess leukocytes in the context of sepsis?
- Improved tissue perfusion
- Systemic inflammation and physiological changes (correct)
- Decrease in capillary permeability
- Localized immune response at the infection site
How does increased capillary permeability contribute to the pathophysiology of sepsis?
How does increased capillary permeability contribute to the pathophysiology of sepsis?
How does the movement of fluid out of the vessels during sepsis impact preload?
How does the movement of fluid out of the vessels during sepsis impact preload?
What is the consequence of decreased intravascular volume in sepsis?
What is the consequence of decreased intravascular volume in sepsis?
Besides reduced blood volume, what other factors contribute to the activation of the clotting cascade?
Besides reduced blood volume, what other factors contribute to the activation of the clotting cascade?
How might the abnormal clotting cascade contribute to the progression of sepsis?
How might the abnormal clotting cascade contribute to the progression of sepsis?
Flashcards
Sepsis
Sepsis
A life-threatening condition where the body's response to infection becomes excessive and systemic, affecting multiple organs.
Sepsis Pathophysiology
Sepsis Pathophysiology
The chain of events involved in sepsis, starting with infection and ending with organ damage.
Immune Response
Immune Response
The body's natural defense against invaders like bacteria and viruses.
Hyperactive Immune Response
Hyperactive Immune Response
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Leukocytes
Leukocytes
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Capillary Dilation and Permeability
Capillary Dilation and Permeability
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Preload
Preload
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Abnormal Clotting Cascade
Abnormal Clotting Cascade
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Study Notes
Sepsis
- Sepsis is the body's extreme response to an infection.
- It's a life-threatening condition.
- Sepsis triggers a chain of physiological reactions throughout the body.
Pathophysiology of Sepsis
- Infection triggers an immune response.
- This response becomes excessive (hyperactive).
- Excess white blood cells (leukocytes) are released systemically.
- Capillaries become more dilated and permeable.
- Fluid leaks out of blood vessels, reducing blood volume.
- Compromised blood flow to organs.
- This can trigger an abnormal clotting cascade (DIC).
- Micro clots block blood flow, restricting oxygen.
- Reduced oxygen leads to anaerobic metabolism.
- Lactic acid builds up, causing metabolic acidosis.
- Cell and tissue death can result in multiple organ failure.
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