Sepsis Management Overview

<p>Obtaining a detailed patient history. (D)</p> Signup and view all the answers

<p>90 to 96 percent (B)</p> Signup and view all the answers

<p>The approach might lead to overtreatment of milder sepsis cases with broad-spectrum antibiotics, conflicting with IDSA's concerns. (D)</p> Signup and view all the answers

<p>Alternative antibiotics, considering the patient's allergies, should be administered as early as possible. (C)</p> Signup and view all the answers

<p>Administer supplemental oxygen and continuously monitor oxygen saturation. (D)</p> Signup and view all the answers

<p>Administration of resuscitative fluids and antibiotics (B)</p> Signup and view all the answers

<p>To decrease the likelihood of false-positive blood cultures (B)</p> Signup and view all the answers

<p>Severity of sepsis (D)</p> Signup and view all the answers

<p>Promptly collect cultures and initiate antimicrobial therapy. (D)</p> Signup and view all the answers

<p>For airway protection related to encephalopathy (B)</p> Signup and view all the answers

<p>To improve the chances of identifying the causative organism and reduce false negatives (D)</p> Signup and view all the answers

<p>Complete blood count with differential and serum lactate (A)</p> Signup and view all the answers

<p>Evidence suggests their value is limited despite their use for monitoring therapeutic response. (A)</p> Signup and view all the answers

<p>If the patient requires vasopressors or has poor peripheral access (C)</p> Signup and view all the answers

<p>Because of potential overestimation of arterial oxygen saturation in Asian, Black, and Hispanic patients compared to White patients (C)</p> Signup and view all the answers

<p>A second specimen should be drawn from a peripheral venipuncture site. (B)</p> Signup and view all the answers

<p>Pre-antimicrobial cultures had a higher sensitivity in detecting pathogens compared to post-antimicrobial cultures. (B)</p> Signup and view all the answers

<p>Targeted imaging based on the suspected site of infection (e.g., chest radiography, CT scan) (A)</p> Signup and view all the answers

<p>The response to treatment and the severity of the disease (A)</p> Signup and view all the answers

<p>The diagnostic value of procalcitonin in patients with sepsis is supported by limited evidence. (D)</p> Signup and view all the answers

<p>To rapidly restore tissue perfusion, mitigating hypovolemia and potential organ damage. (A)</p> Signup and view all the answers

<p>To target the suspected organism(s) and site(s) of infection as early as possible to improve patient outcomes. (B)</p> Signup and view all the answers

<p>No demonstrated mortality benefit compared with protocols using some of these targets or usual care alone. (C)</p> Signup and view all the answers

<p>Improved outcomes in both control and treatment groups, potentially diminishing the observed benefit of EGDT. (B)</p> Signup and view all the answers

<p>Patients with sepsis due to pneumonia or other respiratory tract infections. (D)</p> Signup and view all the answers

<p>Restoration of tissue perfusion and early administration of antibiotics. (A)</p> Signup and view all the answers

<p>Central venous oxyhemoglobin saturation (ScvO2) ≥70 percent (A)</p> Signup and view all the answers

<p>When additional data from well-conducted randomized trials in patients with sepsis are available. (B)</p> Signup and view all the answers

<p>30 mL/kg (D)</p> Signup and view all the answers

<p>Within the first hour. (B)</p> Signup and view all the answers

A clinical syndrome marked by a dysregulated response to infection.

A severe form of sepsis characterized by hypotension and organ dysfunction.

Mortality rates can be ≥10% for sepsis and ≥40% for septic shock.

Immediate management includes securing airway, correcting hypoxemia, and establishing venous access.

Administered to patients with sepsis experiencing hypoxia.

A method to monitor oxygen saturation levels continuously.

Typically targeted between 90 and 96 percent for patients with sepsis.

An organization that provides definitions for sepsis and septic shock management.

Measurement of procalcitonin in guiding antibiotic duration in sepsis.

Empiric antibiotics should be given preferably within the first hour of sepsis diagnosis.

Aggressive IV fluid administration (30 mL/kg) to restore tissue perfusion.

A protocol for sepsis treatment focusing on fluid and antibiotic management within hours.

Key targets: ScvO2 ≥70%, CVP 8-12 mmHg, MAP ≥65 mmHg, urine output ≥0.5 mL/kg/hr.

Improved outcomes observed when tight protocols are followed, despite no mortality benefit in many studies.

Some studies showed mortality benefit from procalcitonin-guided therapy compared to standard care.

Procalcitonin-guided therapy linked to 28-day mortality reduction in certain sepsis patients.

Resuscitation protocols may not show benefits in low-resource environments.

Physical implementation of guidelines can vary, impact outcomes in real-world scenarios.

Pulse oximetry may overestimate arterial oxygen saturation in patients with darker skin pigmentation.

A method to support oxygenation without intubation, often used in cases like sepsis.

Intubation may be needed for airway protection, especially in encephalopathy or reduced consciousness.

Establishing venous access promptly is critical in managing suspected sepsis patients.

A CVC is used for fluid and drug administration, but shouldn’t delay resuscitation.

Include history, labs, microbiology, and imaging to identify the source of infection.

Complete blood count, chemistries, and lactate levels should be obtained promptly in sepsis.

Elevated lactate (>2 mmol/L) indicates sepsis severity and guides therapy response.

Draw blood cultures from at least two different sites before antimicrobial therapy.

Preantimicrobial blood cultures have a higher sensitivity for detecting pathogens in sepsis.

Arterial blood gases may show acidosis, hypoxemia, or hypercapnia in septic patients.

Imaging studies, like X-rays or CT scans, target suspected infection sites.

Procalcitonin levels may aid in diagnosing sepsis despite limited evidence.

Encephalopathy and reduced consciousness can complicate sepsis management.

Used to support oxygenation in patients with respiratory distress, such as sepsis.