Podcast
Questions and Answers
Which of the following is a manifestation of sepsis?
Which of the following is a manifestation of sepsis?
What is the definition of septic shock?
What is the definition of septic shock?
What is the most common cause of hospital admission?
What is the most common cause of hospital admission?
Which patients are most at risk for hospital-acquired sepsis?
Which patients are most at risk for hospital-acquired sepsis?
Signup and view all the answers
What induces pro-inflammatory cytokines in the sepsis pathogenesis?
What induces pro-inflammatory cytokines in the sepsis pathogenesis?
Signup and view all the answers
What happens to the bone marrow in response to sepsis?
What happens to the bone marrow in response to sepsis?
Signup and view all the answers
What effect does sepsis have on blood vessels?
What effect does sepsis have on blood vessels?
Signup and view all the answers
What is a crucial test for sepsis diagnosis and monitoring?
What is a crucial test for sepsis diagnosis and monitoring?
Signup and view all the answers
Which patient factor puts individuals at higher risk for sepsis?
Which patient factor puts individuals at higher risk for sepsis?
Signup and view all the answers
What does UA with reflex C&S aim to detect in sepsis?
What does UA with reflex C&S aim to detect in sepsis?
Signup and view all the answers
Which test is used to identify signs of infection or trauma in sepsis?
Which test is used to identify signs of infection or trauma in sepsis?
Signup and view all the answers
What may be needed if the sepsis diagnosis is not apparent?
What may be needed if the sepsis diagnosis is not apparent?
Signup and view all the answers
Which imaging technique is used to identify sources of infection in sepsis?
Which imaging technique is used to identify sources of infection in sepsis?
Signup and view all the answers
What are some manifestations of sepsis?
What are some manifestations of sepsis?
Signup and view all the answers
What are the criteria for Systemic Inflammatory Response Syndrome (SIRS)?
What are the criteria for Systemic Inflammatory Response Syndrome (SIRS)?
Signup and view all the answers
What is used to assess organ failure risk in patients outside the ICU?
What is used to assess organ failure risk in patients outside the ICU?
Signup and view all the answers
Which stage of shock involves overwhelmed compensatory mechanisms and evident signs of organ dysfunction?
Which stage of shock involves overwhelmed compensatory mechanisms and evident signs of organ dysfunction?
Signup and view all the answers
What are the distinct characteristics and symptoms of pre-shock?
What are the distinct characteristics and symptoms of pre-shock?
Signup and view all the answers
What may patients in end-stage shock exhibit due to overwhelming infection?
What may patients in end-stage shock exhibit due to overwhelming infection?
Signup and view all the answers
What additional testing may be included for sepsis diagnosis?
What additional testing may be included for sepsis diagnosis?
Signup and view all the answers
What is the outcome of end-stage shock?
What is the outcome of end-stage shock?
Signup and view all the answers
What is the most crucial predictor of mortality in sepsis?
What is the most crucial predictor of mortality in sepsis?
Signup and view all the answers
Which IV fluid is recommended for initial resuscitation in sepsis/septic shock?
Which IV fluid is recommended for initial resuscitation in sepsis/septic shock?
Signup and view all the answers
What is the recommended antimicrobial therapy for sepsis?
What is the recommended antimicrobial therapy for sepsis?
Signup and view all the answers
Which pressor is used in distributive shock?
Which pressor is used in distributive shock?
Signup and view all the answers
What is essential for adequate gas exchange assessment in sepsis?
What is essential for adequate gas exchange assessment in sepsis?
Signup and view all the answers
What is a common consequence of inappropriate antibiotic selection in sepsis?
What is a common consequence of inappropriate antibiotic selection in sepsis?
Signup and view all the answers
Which lab abnormality is often seen in sepsis and can lead to mental impairment?
Which lab abnormality is often seen in sepsis and can lead to mental impairment?
Signup and view all the answers
What is crucial for the diagnosis of sepsis?
What is crucial for the diagnosis of sepsis?
Signup and view all the answers
What should antimicrobial therapy consider in sepsis management?
What should antimicrobial therapy consider in sepsis management?
Signup and view all the answers
Study Notes
Sepsis Management and Empiric Antibiotic Therapy
- Lab abnormalities in sepsis often include hypoglycemia leading to mental impairment
- Diagnosis involves assessing recent travel, infectious contacts, and allergies/medication reactions
- Physical examination is crucial to localize the site of infection in the lungs, heart, abdomen, neuro, and skin
- Extensive studies including CBC, chemistries, blood, urine and sputum culture, wound cultures, and CSF exam are necessary for diagnosis
- Time to initiation of appropriate antimicrobial therapy is the strongest predictor of mortality in sepsis
- Inappropriate antibiotic selection is common and markedly increases mortality
- Antimicrobial therapy must consider the source of sepsis, treating the most likely bugs, such as Gram positives, Gram negatives, and anaerobic infections
- Empiric antibiotic therapy includes vancomycin with cephalosporin or beta-lactam/beta-lactamase inhibitor, or combinations if Pseudomonas is a consideration
- IV fluid resuscitation in sepsis/septic shock starts with 0.9% NS or LR at a dose of 30 mL/kg IV within the first three hours
- Pressors like Levophed and dobutamine are used in distributive and cardiogenic shock, respectively
- Hematologic treatment includes Packed RBCs, Fresh frozen plasma, and Platelets
- Adequate gas exchange assessment involves supplemental oxygen, ABG test, intubation, and mechanical ventilation if necessary
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge of sepsis management and empiric antibiotic therapy with this quiz. Learn about lab abnormalities, diagnosis, physical examination, antimicrobial therapy, IV fluid resuscitation, pressors, and hematologic treatment for sepsis and septic shock.
