Self-Nonself Discrimination and Immunological Tolerance Quiz

Questions and Answers

Preventing graft rejection and treating autoimmune diseases

Billingham, Brent, and Medawar

Discovery of acquired immunological tolerance

Specific unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen Signup and view all the answers

It was permanent and antigen-specific Signup and view all the answers

It can be exploited to prevent graft rejection and treat autoimmune diseases Signup and view all the answers

It can be acquired by the introduction of donor cells during fetal development Signup and view all the answers

Specific unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen Signup and view all the answers

Discovery of acquired immunological tolerance Signup and view all the answers

Specific unresponsiveness to an antigen that is induced by exposure of lymphocytes to that antigen Signup and view all the answers

Study Notes

Induction of tolerance is significant as it allows the immune system to distinguish between self and non-self, preventing autoimmune responses.
Peter Medawar experimentally demonstrated that tolerance can be acquired by introducing donor cells during fetal development.

The Nobel Prize in Physiology or Medicine 1960 recognized the discovery of acquired immunological tolerance.

Immunological tolerance is the lack of an immune response to a specific antigen, allowing the immune system to distinguish between self and non-self.

Billingham, Brent, and Medawar demonstrated that acquired tolerance is a state of unresponsiveness to a specific antigen, acquired through exposure to the antigen at a critical period in development.
Acquired tolerance is significant as it allows the immune system to coexist with non-self substances, such as transplanted organs, without mounting an immune response.

The basis of self-nonself discrimination is the ability of the immune system to distinguish between the body's own cells (self) and foreign substances (non-self), which is achieved through the process of immunological tolerance.