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Questions and Answers
What is the significance of the induction of tolerance as mentioned in the text?
What is the significance of the induction of tolerance as mentioned in the text?
Who demonstrated experimentally that tolerance can be acquired by the introduction of donor cells during fetal development?
Who demonstrated experimentally that tolerance can be acquired by the introduction of donor cells during fetal development?
What did the Nobel Prize in Physiology or Medicine 1960 recognize?
What did the Nobel Prize in Physiology or Medicine 1960 recognize?
What is the definition of immunological tolerance as per the text?
What is the definition of immunological tolerance as per the text?
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What did Billingham, Brent, and Medawar demonstrate about acquired tolerance?
What did Billingham, Brent, and Medawar demonstrate about acquired tolerance?
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What is the significance of acquired tolerance as mentioned in the text?
What is the significance of acquired tolerance as mentioned in the text?
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What did Billingham, Brent, and Medawar demonstrate about acquired tolerance?
What did Billingham, Brent, and Medawar demonstrate about acquired tolerance?
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What is the definition of immunological tolerance as per the text?
What is the definition of immunological tolerance as per the text?
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What did the Nobel Prize in Physiology or Medicine 1960 recognize?
What did the Nobel Prize in Physiology or Medicine 1960 recognize?
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What is the basis of self-nonself discrimination as per the text?
What is the basis of self-nonself discrimination as per the text?
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Study Notes
Immunological Tolerance
- Induction of tolerance is significant as it allows the immune system to distinguish between self and non-self, preventing autoimmune responses.
- Peter Medawar experimentally demonstrated that tolerance can be acquired by introducing donor cells during fetal development.
Nobel Prize in Physiology or Medicine 1960
- The Nobel Prize in Physiology or Medicine 1960 recognized the discovery of acquired immunological tolerance.
Immunological Tolerance Definition
- Immunological tolerance is the lack of an immune response to a specific antigen, allowing the immune system to distinguish between self and non-self.
Acquired Tolerance
- Billingham, Brent, and Medawar demonstrated that acquired tolerance is a state of unresponsiveness to a specific antigen, acquired through exposure to the antigen at a critical period in development.
- Acquired tolerance is significant as it allows the immune system to coexist with non-self substances, such as transplanted organs, without mounting an immune response.
Self-Nonself Discrimination
- The basis of self-nonself discrimination is the ability of the immune system to distinguish between the body's own cells (self) and foreign substances (non-self), which is achieved through the process of immunological tolerance.
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Description
Test your knowledge of the principles of cellular and molecular immunology with this quiz on the basis of self-nonself discrimination and immunological tolerance. Explore the significance of self-tolerance and the specific unresponsiveness to antigens induced by lymphocyte exposure. Assess your understanding of tolerogens versus immunogens and their implications in immunology.
