Immunological Tolerance Mechanisms for T-cells and B-cells

Play an AI-generated podcast conversation about this lesson

What is the process by which T cells that bind to self MHC receive signals to trigger apoptosis and die before maturation?

Deletion (apoptosis) (correct)

Differentiation

Activation

Proliferation

Which type of T cells can develop into Regulatory T cells?

B cells

Natural Killer cells

CD8 T cells

CD4 T cells (correct)

What happens to immature B lymphocytes that react with self antigens in the bone marrow?

They undergo proliferation

They differentiate into plasma cells

They undergo positive selection

They are killed (negative selection) (correct)

What occurs when immature B lymphocytes undergo receptor editing?

A new different light chain is produced Signup and view all the answers

Where does central tolerance occur for self antigens?

Bone marrow and thymus Signup and view all the answers

What happens to immature lymphocytes that react with self antigens?

Undergo peripheral tolerance Signup and view all the answers

Which process involves T cells becoming functionally inactivated when recognizing antigens without adequate costimulators?

Clonal anergy Signup and view all the answers

How do self-reactive T cells ignore self antigens in the process of clonal ignorance?

Physical separation Signup and view all the answers

What occurs when T regulatory cells recognize self antigens in the thymus or peripheral tissue?

Block activation of harmful lymphocytes Signup and view all the answers

What happens to mature B lymphocytes that are activated to self antigen without T cell assistance?

Become functionally inactivated and anergic Signup and view all the answers

Why do mature B lymphocytes that are activated to self antigen become incapable of responding to that antigen?

Functionally inactivated and excluded from lymphoid follicles Signup and view all the answers

Immunological Tolerance Mechanisms for T-cells and B-cells

Podcast Beta

Questions and Answers

What is the process by which T cells that bind to self MHC receive signals to trigger apoptosis and die before maturation?

Which type of T cells can develop into Regulatory T cells?

What happens to immature B lymphocytes that react with self antigens in the bone marrow?

What occurs when immature B lymphocytes undergo receptor editing?

Where does central tolerance occur for self antigens?

What happens to immature lymphocytes that react with self antigens?

Which process involves T cells becoming functionally inactivated when recognizing antigens without adequate costimulators?

How do self-reactive T cells ignore self antigens in the process of clonal ignorance?

What occurs when T regulatory cells recognize self antigens in the thymus or peripheral tissue?

What happens to mature B lymphocytes that are activated to self antigen without T cell assistance?

Why do mature B lymphocytes that are activated to self antigen become incapable of responding to that antigen?

More Quizzes Like This

Autoimmunity and Self-Tolerance Quiz

Immunological Tolerance and Autoimmunity Lecture Notes

Immunological Tolerance and Autoimmunity

Immunological Tolerance: Key Concepts and Clinical Relevance

Upgrade to continue