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Questions and Answers
What is the function of phospholipase C in G-protein-coupled receptor signaling?
What is the function of phospholipase C in G-protein-coupled receptor signaling?
- Activate adenylate cyclase to increase cAMP
- Open sodium channels in the plasma membrane
- Break down phosphatidylinositol 4,5-bisphosphate into diacylglycerol and inositol trisphosphate (correct)
- Activate protein kinase A to phosphorylate target proteins
What is the effect of IP3 on the cell?
What is the effect of IP3 on the cell?
- Activation of adenylate cyclase
- Inhibition of protein kinase A
- Increase in sodium ion influx
- Release of calcium ions from the endoplasmic reticulum (correct)
Which of the following is NOT a second messenger in G-protein-coupled receptor signaling?
Which of the following is NOT a second messenger in G-protein-coupled receptor signaling?
- Phospholipase C
- Adenylyl cyclase (correct)
- IP3
- cAMP
What is the role of G-protein-coupled receptors in signal transduction?
What is the role of G-protein-coupled receptors in signal transduction?
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Which ion is NOT involved in the signaling pathway of G-protein-coupled receptors?
Which ion is NOT involved in the signaling pathway of G-protein-coupled receptors?
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Study Notes
G-Protein-Coupled Receptors and Second Messengers
- G-protein-coupled receptors (GPCRs) are essential for cellular signaling and communication.
- They activate various intracellular signaling pathways through the formation of second messengers.
Second Messengers
- A second messenger is a molecule that transmits signals from a receptor to target molecules inside the cell.
Common Second Messengers Associated with GPCRs
- Adenylyl cyclase converts ATP to cyclic AMP (cAMP), which acts as a second messenger influencing various cellular processes.
- Phospholipase C generates inositol trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol, leading to the mobilization of intracellular calcium and activation of protein kinase C.
- IP3 (Inositol trisphosphate), produced by phospholipase C, acts as a second messenger involved in releasing calcium from the endoplasmic reticulum, playing a crucial role in cellular signaling.
Not Considered as Second Messengers
- Sodium ions do not function as second messengers in GPCR signaling pathways. They primarily play roles in establishing membrane potential and nerve signal propagation.
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Description
This quiz is about identifying the correct second messenger of G-protein-coupled (metabotropic) receptors. It's an important topic in biochemistry and cell biology.
