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Routes of Drug Administration Quiz

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Questions and Answers

What are the main factors that affect the choice of route of drug administration?

Physical and chemical properties of the drug, site of desired action, and accuracy of dosage

Physical and chemical properties of the drug, site of desired action, and rate of elimination

Physical and chemical properties of the drug, rate and extent of absorption, and effect of digestive juices (correct)

Site of desired action, accuracy of dosage, and rate and extent of absorption

Which route of drug administration may be used to produce local effects within the gastrointestinal tract?

Subcutaneous route

Intramuscular route

Oral route (correct)

Intravenous route

Which type of drugs are poorly absorbed because they are fully ionized in the gut?

Weakly basic drugs (correct)

Polar drugs

Nonpolar drugs

Weakly acidic drugs

What are the two main mechanisms of drug absorption by the gut?

Passive transfer and carrier-mediated transport Signup and view all the answers

Which mechanism is the most important for drug absorption by the gut?

Passive diffusion Signup and view all the answers

What is the main reason for non-polar lipid-soluble agents being well absorbed from the gut?

Enormous absorptive surface area provided by villi and microvilli Signup and view all the answers

Which mechanism is responsible for the absorption of naturally occurring polar substances?

Active or facilitated transport mechanisms Signup and view all the answers

What can interfere with the absorption of several drugs following surgical interference with gastric function?

Gastrectomy Signup and view all the answers

What may affect drug absorption by interrupting enterohepatic recycling and causing loss of efficacy of oral contraceptives?

Alteration of bowel flora Signup and view all the answers

What is the aim of sustained-release preparations for rapidly eliminated drugs?

To release a steady ‘infusion’ of drug into the gut lumen for absorption during transit through the small intestine Signup and view all the answers