Pharmacology Drug Administration Quiz

<p>All of the above (D)</p> Signup and view all the answers

<p>Suitable for rapid delivery of high drug doses (D)</p> Signup and view all the answers

<p>Most rapid and accurate blood concentration (A)</p> Signup and view all the answers

<p>p-glycoprotein (B), multidrug resistance protein-1 (C)</p> Signup and view all the answers

<p>Inhalation (C)</p> Signup and view all the answers

<p>Area postrema (C)</p> Signup and view all the answers

<p>Non-polar molecules (A)</p> Signup and view all the answers

<p>Intrathecal (A)</p> Signup and view all the answers

<p>Adipose tissue (D)</p> Signup and view all the answers

<p>Blood pressure (D)</p> Signup and view all the answers

<p>Slower onset of action (C)</p> Signup and view all the answers

<p>High binding to depots (D)</p> Signup and view all the answers

<p>Hydrophobic (A)</p> Signup and view all the answers

<p>Oral (PO) (D)</p> Signup and view all the answers

<p>Irritation of nasal passages (A)</p> Signup and view all the answers

<p>Oral (PO) (A)</p> Signup and view all the answers

<p>Slow and variable absorption (C)</p> Signup and view all the answers

<p>Controlled and prolonged absorption (C)</p> Signup and view all the answers

<p>Urine (B)</p> Signup and view all the answers

<p>Enzyme inhibitor (B)</p> Signup and view all the answers

<p>First-order kinetics (B)</p> Signup and view all the answers

<p>Enzyme induction (D)</p> Signup and view all the answers

<p>Weight (D)</p> Signup and view all the answers

<p>Drug competition (D)</p> Signup and view all the answers

<p>Half-life (C)</p> Signup and view all the answers

<p>Blood (B)</p> Signup and view all the answers

<p>It makes the drug more water-soluble. (B)</p> Signup and view all the answers

<p>The drug's route of administration. (B)</p> Signup and view all the answers

<p>They are easily absorbed due to their affinity for cell membranes. (D)</p> Signup and view all the answers

<p>It reduces the effective concentration of a drug in the body. (C)</p> Signup and view all the answers

<p>Increased drug metabolism. (A)</p> Signup and view all the answers

<p>Filtering and removing water-soluble drug products. (B)</p> Signup and view all the answers

<p>Hydrophilic (affinity for water). (D)</p> Signup and view all the answers

<p>The excretion rate is directly proportional to the drug concentration. (A)</p> Signup and view all the answers

<p>Absorption, Distribution, Metabolism, Excretion (D)</p> Signup and view all the answers

<p>The binding of a drug to non-target tissues, which can delay or reduce its effect. (D)</p> Signup and view all the answers

<p>To convert the drug into a form that can be easily excreted. (C)</p> Signup and view all the answers

<p>Drug actions are the specific molecular changes that occur when the drug binds to a receptor, while drug effects are the resulting physiological or psychological alterations. (A)</p> Signup and view all the answers

<p>Neurotransmission (B)</p> Signup and view all the answers

<p>Pharmacokinetics helps to determine the best way to administer drugs. (A)</p> Signup and view all the answers

<p>An agonist activates a receptor, while an antagonist blocks it. (C)</p> Signup and view all the answers

<p>The study of drug actions on the central nervous system and their effects on behavior (C)</p> Signup and view all the answers

<p>Drug solubility (B)</p> Signup and view all the answers

<p>Stomach (C)</p> Signup and view all the answers

<p>Aspirin becomes more soluble in the blood. (C)</p> Signup and view all the answers

<p>Large molecules are too bulky to pass through the tight junctions of brain capillaries. (C)</p> Signup and view all the answers

<p>A non-polar drug with high lipid solubility (B)</p> Signup and view all the answers

<p>The pKa dictates the ratio of ionized to non-ionized forms of the drug at a given pH. (A)</p> Signup and view all the answers

<p>Drug distribution is influenced by both blood flow and tissue characteristics. (C)</p> Signup and view all the answers

<p>Peripheral capillaries are more permeable than brain capillaries. (B)</p> Signup and view all the answers

<p>The BBB effectively blocks the entry of most drugs into the brain. (A)</p> Signup and view all the answers

<p>Transporters are involved in the active transport of drugs across cell membranes. (A)</p> Signup and view all the answers

The study of how drugs are absorbed, distributed, metabolized, and excreted in the body.

An acronym for Absorption, Distribution, Metabolism, and Excretion of drugs.

The process of a drug entering the body fluids after administration.

The dispersal of a drug throughout the body fluids to target tissues.

The biotransformation or inactivation of drugs into metabolites within the body.

Molecular changes due to drug binding at target sites or receptors.

Overall physiological or psychological changes resulting from drug actions.

The relationship between receptors on cells and the ligands (including drugs) that bind to them.

Proteins that actively remove drugs from the extracellular fluid, like p-glycoprotein.

A selective barrier that protects the brain but has specific sites for direct blood access.

Inactive drug binding sites that decrease drug concentration in circulation and prolong effect.

The effect of a drug on a patient influenced by depot binding characteristics.

Variations in drug effects due to different amounts of drug binding in individuals.

Removal of substances or metabolites from the body.

Different ways to deliver drugs into the body.

Drug delivery via the mouth, safe and economical.

Direct drug delivery into the bloodstream for rapid effect.

Liver metabolizes drug before it reaches systemic circulation.

The characteristic that determines a drug's solubility and membrane crossing ability.

Drug delivery through the lungs for rapid absorption.

Drug delivery through the skin for controlled absorption.

Movement of drugs across membranes without energy, down concentration gradients.

Non-polar drugs that can easily diffuse through cell membranes.

Drug injection into muscle for slower absorption.

The pH at which a drug is 50% ionized and 50% non-ionized.

Drug delivery beneath the skin for slow absorption.

Drug delivery directly to a specific area of skin or mucous membrane.

Ionized drugs are charged, non-ionized drugs are uncharged and can diffuse.

The ability of a drug to dissolve in a solvent, affecting absorption.

Refers to whether molecules are hydrophilic or lipophilic, impacting drug behavior.

Intrinsic drug properties and environmental pH that affect absorption rates.

The primary site for drug absorption due to its large surface area.

Movement of a drug from administration site to the bloodstream.

Dispersion of drugs throughout the body after entering circulation.

Molecules that are water-soluble and hydrophilic.

The chemical alteration of a drug by the body, resulting in metabolites.

Enzymes that metabolize drugs into active or inactive forms.

A type of drug elimination where a constant fraction is removed over time.

Non-polar molecules that are easily absorbed in the body.

Polar molecules that dissolve easily in water and are well distributed.

When multiple drugs compete for the same metabolic pathways, affecting effectiveness.

Repeated drug use increases liver enzymes, enhancing drug biotransformation.

Drugs like MAOIs decrease metabolism of themselves and other drugs by targeting enzymes.

Variations in genes affect metabolism rates among individuals.

Individuals with limited CYP2D6 genes, leading to slower drug metabolism.

Individuals with normal CYP2D6 function, process drugs efficiently.

The time required to eliminate half of a drug from circulation.