Drug Administration Routes Quiz
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Questions and Answers

Which route of drug administration is most likely to lead to the first-pass effect?

  • Inhalation
  • Intravenous
  • Subcutaneous
  • Oral (correct)
  • Rectal suppositories intended for adult use usually weigh approximately?

  • 10mg (correct)
  • 5g
  • 20g
  • 2mg
  • Which of the following routes have the highest bioavailability?

  • Inhalation
  • Oral
  • Intravenous (correct)
  • Subcutaneous
  • Vanishing cream is classified as which type of base?

    <p>Water-soluble</p> Signup and view all the answers

    What is the study of absorption, distribution, metabolism and excretion of drugs known as?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What is the advantage of sublingual route of drug administration?

    <p>Avoidance of first-pass metabolism</p> Signup and view all the answers

    What is the principle site of drug absorption for a drug given orally?

    <p>Small intestine</p> Signup and view all the answers

    What is the daily dose of papaverine hydrochloride if a patient is prescribed an intramuscular injection of a 2% solution 1 ml, 2 times a day?

    <p>0.5 g per day</p> Signup and view all the answers

    Which of the following is a phase II drug-metabolizing reaction?

    <p>Glucuronidation</p> Signup and view all the answers

    From which dosage form does a drug, when taken orally, absorb and enter the bloodstream faster?

    <p>Capsule filled with liquid</p> Signup and view all the answers

    What is pharmacokinetics?

    <p>Study of how body interacts with drugs</p> Signup and view all the answers

    Which tissue has the greatest capacity to biotransform drugs?

    <p>Liver</p> Signup and view all the answers

    The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as?

    <p>Passive diffusion</p> Signup and view all the answers

    What characterizes the indicator of pharmacokinetics known as clearance?

    <p>Rate at which drug is removed from plasma relative to its concentration in plasma</p> Signup and view all the answers

    What does the term 'protonation' refer to in pharmacology?

    <p>'Protonation' involves a weak acid becoming less water-soluble and more lipid-soluble at low pH</p> Signup and view all the answers

    What does the volume of distribution (Vd) relate to?

    <p>The amount of drug in the body relative to its concentration in plasma</p> Signup and view all the answers

    Study Notes

    Routes of Drug Administration

    • The oral route is most likely to lead to the first-pass effect.
    • Rectal suppositories intended for adult use usually weigh approximately 1-2 grams.

    Bioavailability

    • The intravenous route has the highest bioavailability.

    Pharmaceutical Bases

    • Vanishing cream is classified as a water-washable base.

    Pharmacokinetics

    • The study of absorption, distribution, metabolism, and excretion of drugs is known as pharmacokinetics.
    • The advantage of sublingual route of drug administration is that it avoids first-pass effect.
    • The principle site of drug absorption for a drug given orally is the small intestine.

    Dosage Calculations

    • If a patient is prescribed an intramuscular injection of 1 ml of 2% papaverine hydrochloride solution, 2 times a day, the daily dose is 40 mg.

    Drug Metabolism

    • Glucuronidation is a phase II drug-metabolizing reaction.

    Drug Absorption

    • A drug taken orally absorbs and enters the bloodstream faster from a solution dosage form.

    Pharmacokinetic Principles

    • Pharmacokinetics is the study of absorption, distribution, metabolism, and excretion of drugs.
    • The liver has the greatest capacity to biotransform drugs.
    • The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as diffusion.
    • Clearance is a pharmacokinetic indicator that characterizes the volume of drug cleared from the body per unit time.
    • Protonation refers to the process of acceptance of a proton (H+ ion) by a drug molecule.
    • The volume of distribution (Vd) relates to the apparent volume of fluid that contains the total amount of drug in the body.

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    Description

    Test your knowledge of drug administration routes with this quiz. Questions cover topics such as first-pass effect, absorption, and the administration of volatile drugs.

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