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Questions and Answers
Which route of drug administration is most likely to lead to the first-pass effect?
Which route of drug administration is most likely to lead to the first-pass effect?
- Inhalation
- Intravenous
- Subcutaneous
- Oral (correct)
Rectal suppositories intended for adult use usually weigh approximately?
Rectal suppositories intended for adult use usually weigh approximately?
- 10mg (correct)
- 5g
- 20g
- 2mg
Which of the following routes have the highest bioavailability?
Which of the following routes have the highest bioavailability?
- Inhalation
- Oral
- Intravenous (correct)
- Subcutaneous
Vanishing cream is classified as which type of base?
Vanishing cream is classified as which type of base?
What is the study of absorption, distribution, metabolism and excretion of drugs known as?
What is the study of absorption, distribution, metabolism and excretion of drugs known as?
What is the advantage of sublingual route of drug administration?
What is the advantage of sublingual route of drug administration?
What is the principle site of drug absorption for a drug given orally?
What is the principle site of drug absorption for a drug given orally?
What is the daily dose of papaverine hydrochloride if a patient is prescribed an intramuscular injection of a 2% solution 1 ml, 2 times a day?
What is the daily dose of papaverine hydrochloride if a patient is prescribed an intramuscular injection of a 2% solution 1 ml, 2 times a day?
Which of the following is a phase II drug-metabolizing reaction?
Which of the following is a phase II drug-metabolizing reaction?
From which dosage form does a drug, when taken orally, absorb and enter the bloodstream faster?
From which dosage form does a drug, when taken orally, absorb and enter the bloodstream faster?
What is pharmacokinetics?
What is pharmacokinetics?
Which tissue has the greatest capacity to biotransform drugs?
Which tissue has the greatest capacity to biotransform drugs?
The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as?
The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as?
What characterizes the indicator of pharmacokinetics known as clearance?
What characterizes the indicator of pharmacokinetics known as clearance?
What does the term 'protonation' refer to in pharmacology?
What does the term 'protonation' refer to in pharmacology?
What does the volume of distribution (Vd) relate to?
What does the volume of distribution (Vd) relate to?
Flashcards
Pharmacokinetics
Pharmacokinetics
The process by which drugs are absorbed, distributed, metabolized, and excreted by the body.
Clearance (Pharmacokinetics)
Clearance (Pharmacokinetics)
The rate at which a drug is removed from the plasma relative to its concentration in the plasma.
Passive Diffusion
Passive Diffusion
The passage of drug molecules from an area of high concentration to an area of low concentration.
Liver and Drug Metabolism
Liver and Drug Metabolism
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Volume of Distribution (Vd)
Volume of Distribution (Vd)
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Protonation
Protonation
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Pharmacokinetics
Pharmacokinetics
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Drug Metabolism
Drug Metabolism
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Drug Distribution
Drug Distribution
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First-Pass Effect
First-Pass Effect
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Bioavailability
Bioavailability
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Small Intestine
Small Intestine
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Sublingual Route
Sublingual Route
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Rectal Suppository
Rectal Suppository
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Intravenous (IV) Route
Intravenous (IV) Route
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Oral Route
Oral Route
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Study Notes
Routes of Drug Administration
- The oral route is most likely to lead to the first-pass effect.
- Rectal suppositories intended for adult use usually weigh approximately 1-2 grams.
Bioavailability
- The intravenous route has the highest bioavailability.
Pharmaceutical Bases
- Vanishing cream is classified as a water-washable base.
Pharmacokinetics
- The study of absorption, distribution, metabolism, and excretion of drugs is known as pharmacokinetics.
- The advantage of sublingual route of drug administration is that it avoids first-pass effect.
- The principle site of drug absorption for a drug given orally is the small intestine.
Dosage Calculations
- If a patient is prescribed an intramuscular injection of 1 ml of 2% papaverine hydrochloride solution, 2 times a day, the daily dose is 40 mg.
Drug Metabolism
- Glucuronidation is a phase II drug-metabolizing reaction.
Drug Absorption
- A drug taken orally absorbs and enters the bloodstream faster from a solution dosage form.
Pharmacokinetic Principles
- Pharmacokinetics is the study of absorption, distribution, metabolism, and excretion of drugs.
- The liver has the greatest capacity to biotransform drugs.
- The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as diffusion.
- Clearance is a pharmacokinetic indicator that characterizes the volume of drug cleared from the body per unit time.
- Protonation refers to the process of acceptance of a proton (H+ ion) by a drug molecule.
- The volume of distribution (Vd) relates to the apparent volume of fluid that contains the total amount of drug in the body.
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Description
Test your knowledge of drug administration routes with this quiz. Questions cover topics such as first-pass effect, absorption, and the administration of volatile drugs.
