Drug Administration Routes Quiz

Routes of Drug Administration

• The oral route is most likely to lead to the first-pass effect.
• Rectal suppositories intended for adult use usually weigh approximately 1-2 grams.

Bioavailability

• The intravenous route has the highest bioavailability.

Pharmaceutical Bases

• Vanishing cream is classified as a water-washable base.

Pharmacokinetics

• The study of absorption, distribution, metabolism, and excretion of drugs is known as pharmacokinetics.
• The advantage of sublingual route of drug administration is that it avoids first-pass effect.
• The principle site of drug absorption for a drug given orally is the small intestine.

Dosage Calculations

• If a patient is prescribed an intramuscular injection of 1 ml of 2% papaverine hydrochloride solution, 2 times a day, the daily dose is 40 mg.

Drug Metabolism

• Glucuronidation is a phase II drug-metabolizing reaction.

Drug Absorption

• A drug taken orally absorbs and enters the bloodstream faster from a solution dosage form.

Pharmacokinetic Principles

• Pharmacokinetics is the study of absorption, distribution, metabolism, and excretion of drugs.
• The liver has the greatest capacity to biotransform drugs.
• The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as diffusion.
• Clearance is a pharmacokinetic indicator that characterizes the volume of drug cleared from the body per unit time.
• Protonation refers to the process of acceptance of a proton (H+ ion) by a drug molecule.
• The volume of distribution (Vd) relates to the apparent volume of fluid that contains the total amount of drug in the body.