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Questions and Answers
Risperidone ISM does not require loading doses or oral supplementation to check for hypersensitivity.
True
Risperidone Doria is currently in a Phase 3 study.
False
All formulations of Risperidone require pre-mixing with oral therapy before treatment.
True
The dosing interval for Risperidone ISM is 2-monthly.
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Risperidone can only be administered via sub-cutaneous injection.
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Aripiprazole lauroxil is intended for repeated dosing in patients requiring long-term treatment.
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Paliperidone palmitate requires a pre-treatment with oral therapy prior to administration.
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Risperidone, as Perseris, is administered through sub-cutaneous injections and requires prior tolerability with oral risperidone.
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The dosage of Paliperidone palmitate is administered every 6 months.
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FDA approval for Aripiprazole lauroxil occurred in 2019.
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Study Notes
Risperidone Long-Acting Injectables
- Risperidone long-acting injectable formulations are available for monthly, bi-monthly, and even six-monthly injections.
- There are various risperidone formulations being investigated, including Risperidone ISM, Risperidone Doria, and Risperidone.
- Risperidone ISM is a long-acting injectable approved by the EMA that does not require loading doses or oral supplementation.
- Risperidone Doria is currently awaiting EMA approval.
- Risperidone is available in two dosing regimens (TV-46000-A & TV-46000-B), both delivered subcutaneously.
- Risperidone ISM is delivered intramuscularly and requires pre-treatment with oral therapy.
Newer Long-Acting Injectable Antipsychotics
- Aristada Initio, containing aripiprazole lauroxil, is a single-dose long-acting injectable for initiating treatment with Aristada.
- Aristada Initio is FDA approved and is administered intramuscularly.
- Aripiprazole requires pre-treatment with oral aripiprazole.
- Paliperidone palmitate is a six-monthly long-acting injectable, currently not available under a trade name.
- It is administered intramuscularly and does not require pre-treatment with oral therapy.
- Perseris is another long-acting injectable containing risperidone. It's FDA approved and administered subcutaneously.
- Perseris does not require loading doses or oral supplementation but may need to establish prior tolerability with oral risperidone.
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Description
Explore the various long-acting injectable formulations of Risperidone and newer alternatives like Aristada Initio. This quiz covers dosing regimens, administration methods, and regulatory approvals for these medications. Test your knowledge on the latest advancements in antipsychotic therapies!
