Rheumatoid Arthritis Oral Agents Quiz
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Questions and Answers

What is the first-line treatment for Multiple Sclerosis (MS) that falls under the category of oral medications?

  • Dimethyl Fumerate (Tecfidera) (correct)
  • Gabapentin
  • Ocrelizumab
  • Baclofen
  • Which medication is commonly used to manage cognitive decline in patients with MS?

  • Donepezil (correct)
  • Pregabalin
  • Amantadine
  • Dalfampridine
  • What is the primary treatment recommended for bowel and bladder dysfunction in MS patients with a hyper-reflexic bladder?

  • Fiber supplements
  • Fingolimod
  • Tizanidine
  • Cholinergic agents (correct)
  • Which medication is indicated for managing spasticity and gait issues in MS patients?

    <p>Baclofen</p> Signup and view all the answers

    What is the tertiary treatment option for Pseudobulbar Palsy in MS patients?

    <p>Dextromethorphan/quinidine</p> Signup and view all the answers

    Which medication is commonly used to address fatigue in MS patients?

    <p>Modafinil</p> Signup and view all the answers

    If a patient with MS experiences acute exacerbations of focal neurologic disturbance lasting more than 24 hours, what is the recommended treatment?

    <p>Methylprednisolone</p> Signup and view all the answers

    What is the primary treatment for UTIs caused by E. coli in patients with MS?

    <p>Bactrim x5-7 days</p> Signup and view all the answers

    What is the recommended pre-medication regimen for Natalizumab (Tysabri) IV infusion?

    <p>Methylprednisolone + Antihistamine + APAP</p> Signup and view all the answers

    Which type of MS is Ocrelizumab (Ocrevus) IV primarily used for?

    <p>Relapsing forms of MS</p> Signup and view all the answers

    What is a common adverse drug reaction (ADR) associated with Alemtuzumab (Lemtrada)?

    <p>Hypothyroidism</p> Signup and view all the answers

    Which medication requires monitoring for JC virus prior to and during therapy?

    <p>Natalizumab (Tysabri)</p> Signup and view all the answers

    Which class of medications is typically used for more severe/progressive forms of MS with less frequent injections?

    <p>Second-Generation Injectables</p> Signup and view all the answers

    What is a common side effect associated with Fingolimod (Gilenya) and similar oral agents?

    <p>Increased liver function tests (LFTs)</p> Signup and view all the answers

    Which medication is a common monotherapy for RRMS in patients unresponsive to other therapies?

    <p>Natalizumab (Tysabri)</p> Signup and view all the answers

    What is a key adverse effect that necessitates close monitoring with Mitoxantrone (Novantrone)?

    <p>Cardiac toxicity</p> Signup and view all the answers

    What is the preferred initial non-biologic agent for mild Rheumatoid Arthritis?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    Which biologic agent is paired with Methotrexate for administration via IV infusion?

    <p>Infliximab</p> Signup and view all the answers

    Which class of medication is NOT recommended to be added immediately after surgery due to its impact on healing?

    <p>mTOR inhibitors</p> Signup and view all the answers

    What is the ADR most commonly associated with Calcineurin Inhibitors like Tacrolimus and Cyclosporine?

    <p>Nephrotoxicity</p> Signup and view all the answers

    Which medication is often used for prophylaxis against Pneumocystis jirovecii pneumonia (PJP) in patients at risk?

    <p>Trimethoprim/sulfamethoxazole</p> Signup and view all the answers

    Which medication is the drug of choice for prophylaxis against cytomegalovirus (CMV) in transplant recipients?

    <p>Valganciclovir</p> Signup and view all the answers

    What is the common treatment regimen for invasive candidiasis?

    <p>Echinocandins</p> Signup and view all the answers

    What is the preferred non-biologic agent for treatment of cutaneous lupus if topical treatments fail?

    <p>Retinoids</p> Signup and view all the answers

    Which antifungal medication requires renal dose adjustment for use in urinary tract infections?

    <p>Fluconazole</p> Signup and view all the answers

    What is the most common adverse effect associated with Flucytosine?

    <p>Myelosuppression</p> Signup and view all the answers

    Which antifungal medication has the highest toxicity level among Amphotericin B, Azoles, and Echinocandins?

    <p>Amphotericin B</p> Signup and view all the answers

    What is the recommended administration requirement for Posaconazole to ensure proper absorption?

    <p>Take with food</p> Signup and view all the answers

    Which HIV medication is associated with the adverse effect of lactic acidosis?

    <p>Zidovudine (AZT)</p> Signup and view all the answers

    Which antifungal medication may lead to long-term skin cancer if used extensively?

    <p>Voriconazole</p> Signup and view all the answers

    Which HIV medication is associated with an increased risk of myocardial infarction (MI)?

    <p>Ziagen (abacavir/ABC)</p> Signup and view all the answers

    Why is renal dose adjustment required for IV Voriconazole despite it being hepatically eliminated?

    <p>'Toxic excipient in IV formulation which is cleared renally'</p> Signup and view all the answers

    Which class of antiretroviral drugs can lead to hepatotoxicity and an increased risk of suicidality?

    <p>Non-nucleoside reverse transcriptase inhibitors</p> Signup and view all the answers

    What is a common side effect associated with the use of Tenofovir disoproxil (TDF)?

    <p>Renal dysfunction (Fanconi’s syndrome)</p> Signup and view all the answers

    Which antiretroviral drug is known for causing lipodystrophy as a long-term complication?

    <p>Reyataz (atazanavir/ATV)</p> Signup and view all the answers

    Which antiretroviral combination drug is approved for use in all populations?

    <p>Truvada (TDF + emtricitabine)</p> Signup and view all the answers

    Which antiretroviral drug is associated with the complication of non-cirrhotic portal hypertension?

    <p>Videx EC (didanosine/ddl)</p> Signup and view all the answers

    What is a common side effect of Non-nucleoside reverse transcriptase inhibitors like Sustiva (efavirenz/EFV)?

    <p>Rash</p> Signup and view all the answers

    Which antiretroviral drug combination should be used with caution in patients with existing psychiatric disease due to its effects?

    <p>Sustiva (efavirenz/EFV) + Viramune (nevirapine/NVP)</p> Signup and view all the answers

    'Biktarvy' is a combination drug that includes which of the following antiretroviral agents?

    <p>*Biktarvy (bictegravir + emtricitabine + TAF)</p> Signup and view all the answers

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