10 Questions
What is the replication strategy of Retroviridae?
Reverse transcription step, DNA copy of genome is integrated into the cellular genome
What is the common feature of all retrovirus genomes?
They have three genes: gag, pol, and env
What is the difference between 'simple' and 'complex' retrovirus genomes?
Simple genomes encode only unspliced and singly spliced mRNAs, while complex genomes encode multiply spliced mRNAs
What is the function of the env gene in retroviruses?
It codes for the viral envelope protein
How do retroviruses transcribe their mRNAs and progeny RNA genomes?
Using host cell RNA Pol II
What is the main difference between retroviruses with simple genomes and complex retroviruses?
Simple retroviruses encode only unspliced and singly spliced mRNAs, while complex retroviruses encode multiply spliced mRNAs.
How do retroviruses ensure transcription of the entire genome?
The viral genome integrates into a precise location relative to a cellular promoter that ensures transcription of the entire genome.
What is the role of SL1 in the retrovirus replication cycle?
SL1 ensures specific recognition of the genome by Gag.
What is the function of RNAse H in the retrovirus replication cycle?
RNAse H cleaves RNA when in duplex form (RNA:RNA, RNA:DNA).
What is the purpose of the polypurine tract (PPT) in the retrovirus replication cycle?
The PPT serves as a primer for reverse transcription.
Test your knowledge of retroviruses, including their structure, genome, and gene expression. Learn about the replication strategy of retroviruses and their ability to cause cancer. This quiz covers the basics of retroviruses and their life cycle.
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