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25. Retroviruses Overview (C114)

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Questions and Answers

What is the replication strategy of Retroviridae?

Budding of new virions from the host cell membrane

Transcription of RNA genome by viral RNA Pol

Reverse transcription step, DNA copy of genome is integrated into the cellular genome (correct)

Translation of RNA genome into protein directly

What is the common feature of all retrovirus genomes?

They have only unspliced and singly spliced mRNAs

They have a DNA genome

They have three genes: gag, pol, and env (correct)

They have multiple accessory genes

What is the difference between 'simple' and 'complex' retrovirus genomes?

Simple genomes encode only unspliced and singly spliced mRNAs, while complex genomes encode multiply spliced mRNAs (correct)

Complex genomes have a larger genome size

Complex genomes have more unspliced mRNAs

Simple genomes have more accessory genes

What is the function of the env gene in retroviruses?

It codes for the viral envelope protein Signup and view all the answers

How do retroviruses transcribe their mRNAs and progeny RNA genomes?

Using host cell RNA Pol II Signup and view all the answers

What is the main difference between retroviruses with simple genomes and complex retroviruses?

Simple retroviruses encode only unspliced and singly spliced mRNAs, while complex retroviruses encode multiply spliced mRNAs. Signup and view all the answers

How do retroviruses ensure transcription of the entire genome?

The viral genome integrates into a precise location relative to a cellular promoter that ensures transcription of the entire genome. Signup and view all the answers

What is the role of SL1 in the retrovirus replication cycle?

SL1 ensures specific recognition of the genome by Gag. Signup and view all the answers

What is the function of RNAse H in the retrovirus replication cycle?

RNAse H cleaves RNA when in duplex form (RNA:RNA, RNA:DNA). Signup and view all the answers

What is the purpose of the polypurine tract (PPT) in the retrovirus replication cycle?

The PPT serves as a primer for reverse transcription. Signup and view all the answers