Respiratory System Drugs and Antihistamines
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Questions and Answers

Which of the following drugs primarily work as bronchodilators?

  • Theophylline (correct)
  • Cromolyn
  • Mucolytics
  • Caffeine

What is the main function of expectorants?

  • Prevent coughing
  • Relax smooth muscles of bronchial tree
  • Treat allergic reactions
  • Increase secretions and reduce viscosity (correct)

Antihistamines are primarily used for which condition?

  • Increasing vital capacity of lungs
  • Preventing severe asthma attacks
  • Treating symptoms of allergies (correct)
  • Curing respiratory infections

Which class of drugs constricts blood vessels in the respiratory tract?

<p>Decongestants (D)</p> Signup and view all the answers

What is the primary role of mucolytics in respiratory therapy?

<p>Liquefy pulmonary secretions (B)</p> Signup and view all the answers

Which type of drug is generally used as a last resort in the management of allergies?

<p>Anti-leukotrienes (C)</p> Signup and view all the answers

What therapeutic purpose do smoking cessation aids like Nicorette gum serve?

<p>Modify behavior for smoking reduction (B)</p> Signup and view all the answers

Which group of medications is used to relieve bronchospasm and is indicated for COPD?

<p>Bronchodilators (C)</p> Signup and view all the answers

What adverse effect is commonly associated with both β1 and β2 agonists?

<p>Anginal pain (C)</p> Signup and view all the answers

Which of the following is not a known adverse effect of montelukast (Singulair)?

<p>Liver dysfunction (A)</p> Signup and view all the answers

Which condition is not typically treated with leukotriene receptor antagonists?

<p>Hypertension (D)</p> Signup and view all the answers

What is a frequently noted side effect of xanthine derivatives such as theophylline?

<p>Dizziness (D)</p> Signup and view all the answers

Which adverse effect is most commonly associated with the use of β2 agonists such as albuterol?

<p>Tremor (D)</p> Signup and view all the answers

Which mechanism of action is attributed to corticosteroids in respiratory treatment?

<p>Reduction of inflammation (B)</p> Signup and view all the answers

What unique adverse effect is associated with zileuton but not with other leukotriene receptor antagonists?

<p>Liver dysfunction (C)</p> Signup and view all the answers

In which situation is the use of anticholinergics contraindicated?

<p>BPH (Benign Prostatic Hyperplasia) (C)</p> Signup and view all the answers

Flashcards

Bronchodilators

A type of drug that relaxes smooth muscles in the bronchial tree, relieving bronchospasm and expanding lung capacity.

Sympathomimetics (Adrenergics)

A category of bronchodilators that work by mimicking the effects of adrenaline, relaxing airway muscles.

Parasympatholytics (Anticholinergics)

A category of bronchodilators that block the action of acetylcholine, a neurotransmitter that constricts airways.

Mucolytics

A type of drug that liquefies thick mucus in the lungs, making it easier to cough up.

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Expectorants

A type of drug that increases mucus production, making it thinner and easier to expel.

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Antitussives

A type of drug that suppresses coughing by acting on the cough center in the brain.

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Antihistamines

A type of drug that competes with histamine for binding sites, blocking the effects of histamine and reducing allergy symptoms.

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Decongestants

A type of drug that constricts blood vessels in the respiratory tract, reducing swelling and congestion.

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What are beta-agonists?

Beta-agonists are a class of drugs that work by stimulating beta-adrenergic receptors, which are found in the smooth muscles of the bronchi. This stimulation leads to bronchodilation, which means the airways relax and widen, making it easier to breathe.

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What are the adverse effects of beta-agonists?

The primary adverse effects of beta-agonists include cardiac stimulation (increased heart rate), tremor, and anginal pain. These effects are more common with beta-1 agonists, but can also occur with beta-2 agonists. Additionally, beta-2 agonists can cause hypotension or hypertension, vascular headache, and tremor.

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How do xanthine derivatives work?

Xanthine derivatives are a class of drugs that work by inhibiting the breakdown of cAMP, a molecule that plays a role in smooth muscle relaxation. This increased cAMP levels lead to bronchodilation.

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What are the adverse effects of xanthine derivatives?

The main adverse effects of xanthine derivatives include nausea, vomiting, headache, insomnia, and seizures.

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What are antileukotrienes?

Antileukotrienes, also known as leukotriene receptor antagonists (LRTAs), are medications that work by blocking the actions of leukotrienes. Leukotrienes are inflammatory chemicals that cause bronchoconstriction and contribute to asthma symptoms.

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What are the indications for antileukotrienes?

The main indications for antileukotrienes include the treatment of asthma, particularly in patients who are not adequately controlled with other medications. They are often used as maintenance therapy to prevent asthma attacks rather than for acute relief.

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What are inhaled corticosteroids?

Inhaled corticosteroids are a type of steroid medication that is delivered directly to the lungs. They have anti-inflammatory effects that help reduce airway inflammation and improve lung function. They are often used for long-term maintenance of asthma.

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What are the adverse effects of corticosteroids?

The main adverse effects of corticosteroids are related to their systemic effects when they are absorbed into the bloodstream. These include weight gain, osteoporosis, high blood sugar, and cataracts. However, inhaled corticosteroids have fewer systemic effects due to their targeted delivery to the lungs.

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Study Notes

Respiratory System Drugs and Antihistamines

  • Oxygen: Administration of oxygen, side effects, cautions
  • Key Terms: Ventilation, perfusion, diffusion, pulmonary circulation, surfactant, pneumocytes
  • Respiratory Stimulants: Caffeine, theophylline, carbon dioxide inhalations, bronchodilators
  • Bronchodilators: Relax smooth muscles of bronchial tree, relax bronchospasm, increase vital capacity of lungs; used for acute respiratory conditions and COPD
  • Sympathomimetics (adrenergics): Metered dose inhalers, breath-actuated inhalers
  • Parasympatholytics (anticholinergics):
  • Xanthines:
  • Corticosteroids:
  • Asthma Prophylaxis: Anti-leukotrienes, cromolyn
  • Mucolytics and Expectorants: Mucolytics (liquefy pulmonary secretions), expectorants (increase secretions, reduce viscosity, and expel sputum), antitussives (prevent coughing), antihistamines (treat symptoms of allergies; adjunct treatment of anaphylactic reactions)
  • Decongestants: Used for short-term treatment of respiratory tract
  • Smoking Cessation Aids: Nicotine gum, Nicoderm patch, Nicotrol inhaler, behavior modification

Lower Respiratory Tract Diseases

  • Asthma: Recurrent and reversible shortness of breath, bronchospasm, inflammation and edema of bronchus mucosa, production of thick mucus, wheezing, difficulty breathing, status asthmaticus (prolonged asthma attacks)
  • Chronic Bronchitis: Continuous inflammation of bronchi and bronchioles, often results from exposure to bronchial irritants, characterized by chronic productive cough ("blue bloater"), hypoxemia
  • Emphysema: Air spaces enlarge by destruction of alveolar walls, reduced surface area for gas exchange, difficulty exhaling ("pink puffer")
  • COPD Drugs: Long-term control (antileukotrienes, cromolyn, inhaled steroids, long-acting beta-agonists) and quick-relief (IV/systemic corticosteroids, short-acting beta-agonists, bronchodilators)

Other Drugs

  • Three types of Nonselective adrenergics: Stimulate α, β, (cardiac), and β₂ (respiratory), receptors; examples: Epinephrine.
  • Mechanism of Action: Begins at the specific receptor stimulated; ends with the dilation of the airways.
  • Indications: Relief of bronchospasm, useful in treatment of acute attacks, used in hypotension and shock, used to prevent premature labor, hyperkalemia-stimulates potassium
  • B-Agonists Adverse Effects: Cardiac stimulation, tremor, anginal pain, hypotension, hypertension
  • Nursing Implications: Thorough assessment; baseline vital signs; respiratory assessment; including PO2
  • Antileukotrienes: Uses: prophylaxis and chronic treatment of asthma, NOT for acute attacks
  • Adverse Effects: Headache, dyspepsia, nausea, diarrhea, dizziness, insomnia, liver dysfunction (with montelukast)
  • Corticosteroids: Anti-inflammatory effects, used for chronic asthma and COPD exacerbations, take several weeks to show full effects
  • Inhaled Corticosteroids: Lower systemic effects, examples: beclomethasone, triamcinolone

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Description

This quiz covers essential drugs used in the respiratory system, including oxygen therapy, bronchodilators, and antihistamines. Explore key terms and treatment options for various respiratory conditions, such as asthma and COPD. Test your knowledge on the mechanisms and side effects of these medications.

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