Respiratory Immunology Quiz

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Questions and Answers

What is the date of the Respiratory System I class?

November 29th, 2023 (correct)

October 29th, 2023

November 30th, 2023

December 1st, 2023

Who is the author of the reading material 'Primer to the Immune Response'?

Mak et al. (correct)

Davidson

Abbas et al.

Walker, Brian R.

What is the name of the book from which Chapter 14 is linked?

Primer to the Immune Response

Cellular and Molecular Immunology (correct)

Davidson's Principles and Practice of Medicine

Host Defense Mechanisms of the Lung

What is Dr. Marc Benson's office hours?

E-mail for appointment or stop by office Signup and view all the answers

What is the title of the book authored by Walker, Brian R.?

Davidson's Principles and Practice of Medicine Signup and view all the answers

What is the email address to contact Dr. Marc Benson?

<a href="mailto:[email protected]">[email protected]</a> Signup and view all the answers

What is the phone number to contact Dr. Marc Benson?

(575) 674-2317 Signup and view all the answers

Where can detailed information about copyright guidelines be found?

<a href="https://bcomnm.org/copyrightguidelines/">https://bcomnm.org/copyrightguidelines/</a> Signup and view all the answers

What is the title of the book authored by Abbas et al.?

Cellular and Molecular Immunology Signup and view all the answers

What is the office number of Dr. Marc Benson?

317 Signup and view all the answers

What are the components of the immune tissue in the respiratory tract?

Diffuse lymphoid tissue, nodular lymphoid tissue, and tonsils Signup and view all the answers

What does systems immunology emphasize?

The relationship between anatomy, function, and immune response Signup and view all the answers

What is the aim of the lung microbiome?

To maintain immune tolerance and prevent aberrant inflammation Signup and view all the answers

What are examples of non-specific secreted factors in the respiratory tract?

Anti-microbial peptides, mucus, and collectins Signup and view all the answers

What is the key function of mucociliary transport in the respiratory tract?

Removing contaminants from the lung and preventing infection Signup and view all the answers

What age-related changes affect immune response in the respiratory tract?

Decreased efficiency of mucociliary transport Signup and view all the answers

What is a key part of respiratory defense involving high-pressure expiration and irritant receptor stimulation?

Cough Signup and view all the answers

What are the objectives of the lecture outline?

Cover innate and adaptive immune responses, mucociliary system, and immune tissue location Signup and view all the answers

What is the main emphasis of innate immune response in the respiratory tract?

Cough, lung microbiome, non-specific secreted factors, and mucociliary transport Signup and view all the answers

What does respiratory tract epithelium need to balance?

Immune response with infection control Signup and view all the answers

Which cells in the respiratory tract sample the lung environment and migrate to draining lymph nodes to present antigens to naïve T cells?

Dendritic cells Signup and view all the answers

What is the primary function of nasal-associated lymphoid tissue (NALT) in the respiratory tract?

Recognize antigens and induce immune responses Signup and view all the answers

Which immunodeficiency is characterized by low IgA levels and is associated with respiratory tract infections, GI infections, and autoimmune diseases?

Selective IgA deficiency (SIgAD) Signup and view all the answers

What is the mechanism by which IgA and IgM are transported across mucosal epithelial surfaces?

Transcytosis mediated by the poly-Ig receptor (pIgR) and the J chain Signup and view all the answers

Which cells are involved in the germinal center reaction and undergo somatic hypermutation and affinity maturation?

B cells Signup and view all the answers

What is the role of the innate immune response in the respiratory tract?

Recognize microbial pathogens and damaged host cells Signup and view all the answers

Which cells form a tight barrier with intercellular junctions and have specialized functions such as ciliary movement and mucin secretion?

Epithelial cells Signup and view all the answers

What is the function of the effector functions of antibodies, including IgA, IgG, and IgM?

Opsonization, antibody-dependent cell-mediated cytotoxicity, complement activation, neutralization, and transport across epithelium Signup and view all the answers

What do resident macrophages in the lungs primarily recognize and dispose of?

Inhaled microbes Signup and view all the answers

Which source provides detailed information on respiratory immunology, as referenced in the text?

Murray and Nadel's Textbook of Respiratory Medicine Signup and view all the answers

Study Notes

Immunological Processes in the Respiratory Tract

Epithelial cells form a tight barrier with intercellular junctions, including tight and adherens junctions, and have specialized functions such as ciliary movement, mucin secretion, and secretion of surfactant proteins.
Resident macrophages in the lungs recognize and dispose of inhaled microbes, phagocytose, present antigens, and produce cytokines, playing a major role in maintaining lung homeostasis.
Dendritic cells in the respiratory tract sample the lung environment and, upon antigen recognition, migrate to draining lymph nodes to present antigens to naïve T cells.
The innate immune response involves the recruitment of immune cells and activation of the adaptive immune response through the recognition of microbial pathogens and damaged host cells by pattern recognition receptors (PRRs).
The nasal-associated lymphoid tissue (NALT) contains immune cells that recognize antigens and induce immune responses, leading to the activation of memory cells and antibody production.
The effector functions of antibodies, including IgA, IgG, and IgM, involve opsonization, antibody-dependent cell-mediated cytotoxicity, complement activation, neutralization, and transport across epithelium.
Selective IgA deficiency (SIgAD) is a primary humoral immunodeficiency characterized by low IgA levels and is associated with respiratory tract infections, GI infections, and autoimmune diseases.
IgA and IgM are transported across mucosal epithelial surfaces through transcytosis mediated by the poly-Ig receptor (pIgR) and the J chain.
The germinal center reaction involves the formation of secondary follicles with dark and light zones, where B cells undergo somatic hypermutation and affinity maturation, and interact with follicular dendritic cells and Tfh cells to induce class switching and differentiation.
The lecture outline covers pre-lecture clicker questions, objectives, immune tissue of the respiratory tract, innate and adaptive immune responses, post-lecture clicker questions, and sample questions.
The text references sources such as "Murray and Nadel's Textbook of Respiratory Medicine" and "Principles of Mucosal Immunology" for detailed information on respiratory immunology.
The content provides a comprehensive understanding of the immunological processes in the respiratory tract, including the innate and adaptive immune responses, effector functions of antibodies, and specific immunodeficiencies.

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Description

Test your knowledge of immunological processes in the respiratory tract with this quiz. Explore topics such as epithelial cell barriers, macrophage functions, dendritic cell migration, innate and adaptive immune responses, antibody effector functions, and specific immunodeficiencies. The quiz covers essential concepts in respiratory immunology and includes references for further reading.