Podcast
Questions and Answers
What is a common pathogenic factor in the renal pathology of malignant hypertension and thrombotic microangiopathies?
What is a common pathogenic factor in the renal pathology of malignant hypertension and thrombotic microangiopathies?
- Endothelial injury (correct)
- Elevated angiotensin II levels
- Increased renin production
- Sodium retention
In cases of malignant hypertension, what percentage of cases may present with microangiopathic hemolytic anemia?
In cases of malignant hypertension, what percentage of cases may present with microangiopathic hemolytic anemia?
- 50%
- 10%
- 30% (correct)
- 20%
What is the primary cause of hypertension secondary to renal artery stenosis?
What is the primary cause of hypertension secondary to renal artery stenosis?
- Sodium retention
- Increased renin production (correct)
- Endothelial injury
- Elevated angiotensin II levels
Which experiments demonstrated that constriction of one renal artery in dogs leads to hypertension?
Which experiments demonstrated that constriction of one renal artery in dogs leads to hypertension?
What effect does the reduction of angiotensin II activity have on individuals with renovascular hypertension?
What effect does the reduction of angiotensin II activity have on individuals with renovascular hypertension?
Which factor contributes to the maintenance of renovascular hypertension after the renin-angiotensin system has initiated it?
Which factor contributes to the maintenance of renovascular hypertension after the renin-angiotensin system has initiated it?
Where is the PKD1 gene located?
Where is the PKD1 gene located?
What is the function of polycystin-1?
What is the function of polycystin-1?
What percentage of cases do mutations in PKD1 account for?
What percentage of cases do mutations in PKD1 account for?
At what age does the likelihood of developing renal failure reach more than 70% for individuals with mutations in PKD1?
At what age does the likelihood of developing renal failure reach more than 70% for individuals with mutations in PKD1?
Which type of cells express polycystin-1 predominantly?
Which type of cells express polycystin-1 predominantly?
Why has the genetic diagnosis of Polycystic Kidney Disease been complicated?
Why has the genetic diagnosis of Polycystic Kidney Disease been complicated?
What is one of the reasons why renal cysts are considered important?
What is one of the reasons why renal cysts are considered important?
What is a major consequence of adult polycystic kidney disease?
What is a major consequence of adult polycystic kidney disease?
How common is autosomal dominant polycystic kidney disease among live births?
How common is autosomal dominant polycystic kidney disease among live births?
In autosomal dominant polycystic kidney disease, how many alleles of the involved genes need to be nonfunctional for the disease to develop?
In autosomal dominant polycystic kidney disease, how many alleles of the involved genes need to be nonfunctional for the disease to develop?
Why are unilateral cases of adult polycystic kidney disease rare?
Why are unilateral cases of adult polycystic kidney disease rare?
What is the inheritance pattern of autosomal dominant polycystic kidney disease?
What is the inheritance pattern of autosomal dominant polycystic kidney disease?
What is the role of the VHL gene in clear cell cancers?
What is the role of the VHL gene in clear cell cancers?
What happens to HIF-1 levels when VHL is inactive?
What happens to HIF-1 levels when VHL is inactive?
Which transcription factor is targeted by the VHL protein for degradation?
Which transcription factor is targeted by the VHL protein for degradation?
What is the consequence of high HIF-1 levels under normoxic conditions?
What is the consequence of high HIF-1 levels under normoxic conditions?
What is the key pathogenic abnormality in most cases of atypical HUS?
What is the key pathogenic abnormality in most cases of atypical HUS?
What is the histologic appearance of diffuse cortical necrosis?
What is the histologic appearance of diffuse cortical necrosis?
What toxin is responsible for producing platelet activation and thrombosis in typical HUS?
What toxin is responsible for producing platelet activation and thrombosis in typical HUS?
What type of necrosis is predominantly seen in massive ischemic necrosis affecting the renal cortex?
What type of necrosis is predominantly seen in massive ischemic necrosis affecting the renal cortex?
Which factor permits the formation of abnormally large multimers of vWF in TTP?
Which factor permits the formation of abnormally large multimers of vWF in TTP?
What are the key characteristics of thrombotic microangiopathy?
What are the key characteristics of thrombotic microangiopathy?
