Immunofluorescence in Glomerular Lesions

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Questions and Answers

What is the characteristic immunofluorescence pattern of antigen-antibody complexes in glomerular lesions?

  • Homogeneous deposition
  • Linear deposition
  • Speckled pattern
  • Granular pattern (correct)

Which type of glomerulonephritis is characterized by loss of BM polyanions and reduced negative charge on the membrane?

  • Minimal Change GN (correct)
  • Membranous GN
  • Focal Segmental GN
  • Post-infectious GN

What is the common complication of Minimal Change GN?

  • Hematuria
  • Proteinuria (correct)
  • Nephritic syndrome
  • Hypertension

What is the likely cause of Minimal Change GN?

<p>Immunologic attack (D)</p> Signup and view all the answers

What is the characteristic electron microscopy finding in Minimal Change GN?

<p>Fusion of foot processes (C)</p> Signup and view all the answers

Which type of antibody is responsible for linear deposition of immune complexes in glomerular lesions?

<p>Anti-GBM antibody (A)</p> Signup and view all the answers

What is the mechanism of antibody-mediated glomerular injury in situ?

<p>Antigen-antibody complexes in the glomerulus (B)</p> Signup and view all the answers

What is the role of T-lymphocytes in Minimal Change GN?

<p>Production of cytokines (D)</p> Signup and view all the answers

What is the primary focus of treatment for diabetic nephropathy?

<p>Managing hypertension and hyperglycemia (A)</p> Signup and view all the answers

What is the characteristic feature of minimal change disease?

<p>Loss of polyanions on the basement membrane (D)</p> Signup and view all the answers

What is the consequence of glycation in diabetic nephropathy?

<p>Hyaline arteriosclerosis of the efferent artery, GBM thickening and dilation of the afferent artery (D)</p> Signup and view all the answers

What is the definition of pyelonephritis?

<p>Inflammation of the kidney mostly due to bacterial infection (B)</p> Signup and view all the answers

What is the complication of diabetic nephropathy that leads to reduced GFR?

<p>Glomerular damage (C)</p> Signup and view all the answers

What is the type of glomerulonephritis characterized by in situ Ag-Ab complexes?

<p>Membranous glomerulonephritis (D)</p> Signup and view all the answers

What is the stage of diabetic nephropathy characterized by hyperfiltration?

<p>Early stage (C)</p> Signup and view all the answers

What is the type of glomerulonephritis characterized by anti-GBM antibody?

<p>Goodpasture's syndrome (D)</p> Signup and view all the answers

What is the primary characteristic of immunofluorescence in membranous GN?

<p>Linear Immune Complex along BM (C)</p> Signup and view all the answers

What is the main cause of iron deficiency anemia in patients with membranous GN?

<p>Chronic blood loss (A)</p> Signup and view all the answers

What is the primary mechanism of damage to the GBM in membranous GN?

<p>BM thickening and inflammation (A)</p> Signup and view all the answers

What is the primary effect of hyperglycemia on the efferent arterioles in diabetic nephropathy?

<p>Constriction (B)</p> Signup and view all the answers

What is the characteristic histopathological feature of diabetic nephropathy?

<p>Kimmelstiel-Wilson nodules (A)</p> Signup and view all the answers

What is the long-term effect of diabetic nephropathy on the glomerular filtration rate?

<p>Decreased GFR (A)</p> Signup and view all the answers

What is the primary effect of non-enzymatic glycation of protein in diabetic nephropathy?

<p>Glycation of basement membrane (B)</p> Signup and view all the answers

What is the final outcome of the progression of mesangial matrix expansion in diabetic nephropathy?

<p>Consumption of the entire glomerulus (B)</p> Signup and view all the answers

What is the primary reason for the concentration of protein in urine in pre-renal causes?

<p>Reduced tissue perfusion leading to reduced GFR (B)</p> Signup and view all the answers

What is the primary indication of glucose in urine?

<p>Renal glycosuria (B)</p> Signup and view all the answers

Which of the following is a hallmark of liver disease?

<p>Presence of urobilinogen in urine (C)</p> Signup and view all the answers

What is the primary indication of hematuria in urine?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary difference between dysmorphic RBC and intact RBC in urine analysis?

<p>Dysmorphic RBC is seen in glomerular disorders, while intact RBC is seen in post-renal disorders (B)</p> Signup and view all the answers

What is the primary indication of myoglobin in urine?

<p>Rhabdomyolysis (D)</p> Signup and view all the answers

What is the primary difference between Bence Jones protein and other proteins in urine analysis?

<p>Bence Jones protein is detectable by electrophoresis, while other proteins are detectable by dipstick (B)</p> Signup and view all the answers

What is the primary indication of hyaline casts in urine?

<p>Reduced tissue perfusion leading to reduced GFR (B)</p> Signup and view all the answers

What is the primary outcome of Renal Tubular Acidosis (RTA)?

<p>Basic pH of urine (B)</p> Signup and view all the answers

What is the underlying mechanism of Polyuria?

<p>Defective renal concentration ability (A)</p> Signup and view all the answers

What is the most common type of stone formed in Nephrolithiasis?

<p>Calcium (B)</p> Signup and view all the answers

What is the primary cause of supersaturation of solute in urine?

<p>All of the above (D)</p> Signup and view all the answers

What is the best test to estimate Glomerular Filtration Rate (GFR)?

<p>Inulin clearance (B)</p> Signup and view all the answers

What is the primary goal of Hemodialysis and Peritoneal Dialysis?

<p>To remove waste products from the blood (A)</p> Signup and view all the answers

What is the characteristic of Distal Renal Tubular Acidosis (RTA)?

<p>Inability to secrete hydrogen ions (D)</p> Signup and view all the answers

What is the primary investigation for Renal Tubular Acidosis (RTA)?

<p>Administration of acid/basic load (A)</p> Signup and view all the answers

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