Rehabilitation and Inflammation Quiz

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Questions and Answers

What is the primary role of interleukin-1 (IL-1) in inflammation?

  • Produce local and systemic effects (correct)
  • Induce pain
  • Cause platelet aggregation
  • Increase vascular permeability

Which chemical mediator of inflammation is known for its role in increasing platelet aggregation?

  • Cytokines
  • Platelet Activating Factor (correct)
  • Histamine
  • Arachidonic Acid Derivatives

What is a common characteristic of Type I collagen?

  • Random structural arrangement
  • Less tensile strength
  • Involved in leukocyte chemotaxis
  • Thick and strong bundle (correct)

Which pathway produces leukotrienes that aid in chemotaxis of leukocytes?

<p>Lipoxygenase pathway (C)</p> Signup and view all the answers

What is a significant consequence of noncompliance in patients experiencing acute inflammation?

<p>Increased likelihood of chronic inflammation (B)</p> Signup and view all the answers

What is the expected strength of tissue after rehabilitation at best?

<p>80% of pre-injury strength (D)</p> Signup and view all the answers

What approach should be taken during the inflammatory/acute stage of rehabilitation?

<p>Minimize pain and control edema (D)</p> Signup and view all the answers

Which mobilization grades are appropriate during the proliferation/subacute stage?

<p>Grade III/IV mobilizations (C)</p> Signup and view all the answers

Which of the following is NOT recommended during the inflammatory/acute stage?

<p>Aggressive resistance training (C)</p> Signup and view all the answers

What is one of the primary goals during the proliferation/subacute stage of rehabilitation?

<p>Prevent scar contracture (C)</p> Signup and view all the answers

What is a primary goal during the maturation/chronic stage of rehabilitation?

<p>Return to function (C)</p> Signup and view all the answers

Which factor can impede the healing potential of skeletal muscle after an injury?

<p>Completely immobilizing the muscle (C)</p> Signup and view all the answers

Fibrosis in muscle repair is associated with which of the following?

<p>Increased ECM material at the repair site (C)</p> Signup and view all the answers

What characterizes a Grade II soft tissue injury?

<p>Structural tearing of more than 50% of fibers (B)</p> Signup and view all the answers

What is a likely consequence of continued inflammation during muscle healing?

<p>Disorganized collagen formation (A)</p> Signup and view all the answers

What characterizes irreversible cell injury?

<p>Necrosis and cell death (D)</p> Signup and view all the answers

Which of the following is a hallmark of acute inflammation?

<p>Edema from exudate (A)</p> Signup and view all the answers

What occurs during acute reversible cell injury?

<p>Increased intracellular Na and Ca (C)</p> Signup and view all the answers

What is a common response during chronic inflammation?

<p>Accumulation of macrophages and lymphocytes (A)</p> Signup and view all the answers

Which factor does NOT affect the inflammatory response?

<p>Available nutrients (B)</p> Signup and view all the answers

What happens when a stressor is removed during reversible cell injury?

<p>Normal structure and function may return (B)</p> Signup and view all the answers

Which substance is typically released into circulation during irreversible cell injury?

<p>Byproducts measurable by blood tests (C)</p> Signup and view all the answers

Which of the following is a consequence of chronic inflammation?

<p>Tissue hyperplasia and scarring (C)</p> Signup and view all the answers

What are the main factors that determine the body's response to physical stress?

<p>Magnitude of force, time, and direction of force (C)</p> Signup and view all the answers

Which of the following correctly describes irreversible cell injury?

<p>Necrosis that leads to permanent cell loss (B)</p> Signup and view all the answers

What is a primary stage of tissue healing?

<p>Inflammation (A)</p> Signup and view all the answers

How does high-magnitude stress affect tissues?

<p>It leads to cumulative injury or damage (A)</p> Signup and view all the answers

What is NOT a common factor influencing muscle response to stress?

<p>Warm-up duration (C)</p> Signup and view all the answers

Which type of cell injury is characterized by permanent damage?

<p>Necrosis (C)</p> Signup and view all the answers

What sequence represents the correct order in the healing process?

<p>Inflammation, proliferation, remodeling (C)</p> Signup and view all the answers

Which of the following statements is true regarding the effects of physical stress on tissues?

<p>Increased duration of low-magnitude stress can lead to injury (B)</p> Signup and view all the answers

What is the primary type of collagen found in tendon tissue?

<p>Type I collagen (C)</p> Signup and view all the answers

Which of the following is a risk factor for rhabdomyolysis?

<p>High dose statins (C)</p> Signup and view all the answers

During the maturation phase of tendon healing, which type of collagen replaces Type III collagen?

<p>Type I collagen (A)</p> Signup and view all the answers

What is a common symptom of rhabdomyolysis?

<p>Tea or cola colored urine (C)</p> Signup and view all the answers

What occurs during the initial hemostasis phase of tendon repair?

<p>Fibronectin and fibrin cross-linking (C)</p> Signup and view all the answers

Chronic tendinopathy is characterized by which of the following?

<p>Disordered healing of tendon tissue (D)</p> Signup and view all the answers

Which statement is true regarding the healing of extra-articular ligaments?

<p>They can take up to 3 years to heal (B)</p> Signup and view all the answers

What is the appropriate treatment for severe rhabdomyolysis?

<p>IV fluids and dialysis (D)</p> Signup and view all the answers

In tendon injuries, what typically causes a rupture?

<p>Macroscopic failure from excessive force (C)</p> Signup and view all the answers

What is a potential complication of tendon healing?

<p>Adhesion formation (B)</p> Signup and view all the answers

Flashcards

Reversible Cell Injury

A state where cells are temporarily damaged, but can recover and return to normal function if the stress is removed.

Irreversible Cell Injury

Cell damage that is so severe that the cell cannot recover and dies.

Tissue Healing

A process by which tissues repair themselves after injury.

Physical Stress Theory

A theory that explains how physical stress impacts tissue adaptations and injury.

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Atrophy

A decrease in the size of cells or tissues due to disuse, malnutrition, or other factors.

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Hypertrophy

An increase in the size of cells or tissues due to increased workload or other stimuli.

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Inflammation

The process of inflammation, the body's response to tissue injury, involving redness, swelling, heat, and pain.

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Physical Therapy Interventions

A range of treatments used to help improve function and restore mobility after injury, such as exercise, manual therapy, and modalities.

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Necrosis

A type of cell death characterized by the breakdown of cell structures and the release of their contents into the surrounding tissues.

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Type I Collagen

A type of collagen found in tendons, ligaments, and other tissues that provides strength and flexibility.

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Type III Collagen

A type of collagen found in skin, cartilage, and other tissues that provides elasticity and flexibility.

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Collagen

A protein found in the extracellular matrix that helps to provide structure and support to tissues.

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Acute Reversible Cell Injury

Increased intracellular sodium and calcium levels lead to swelling of the cytosol, mitochondria, and endoplasmic reticulum. This process can be reversed if the stressor is removed.

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Inflammatory Response

The body's response to cell injury aimed at removing harmful agents, dead cells, and debris. It also initiates tissue healing and involves innate immune responses.

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Pro-inflammatory Mediators

This involves the release of pro-inflammatory mediators, including cytokines, interleukins, tumor necrosis factor, and growth factors. These mediators activate the immune response.

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Acute Inflammation

Inflammation with a rapid onset and short duration, characterized by redness, swelling, heat, and pain. It's caused by exudate accumulation.

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Chronic Inflammation

Inflammation that persists for a longer duration, involving an accumulation of macrophages and lymphocytes. It is associated with hypervascularity and fibrosis.

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Causes of Chronic Inflammation

Chronic inflammation can occur when the injurious agent isn't addressed or there is extensive necrosis, like burns or wide wound edges.

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Tissue Healing Strength

After injury, the final healed tissue strength is only approximately 80% of the original tissue's strength.

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Inflammatory/Acute Stage

The initial stage of tissue healing where the body's primary goal is to control swelling and minimize pain.

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Proliferation/Subacute Stage

This stage focuses on stimulating collagen production to help rebuild the damaged tissue.

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Remodeling/Chronic Stage

This stage focuses on regaining strength, flexibility, and neuromuscular control after tissue healing.

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Proliferation

The stage after injury where the body starts to rebuild the damaged tissue with new collagen fibers.

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Skeletal Muscle Healing

The ability of skeletal muscle to repair itself after injury. It can be impaired by factors like re-injury or prolonged inflammation.

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Fibrosis

An excessive amount of extracellular matrix (ECM) material at the site of a muscle injury, leading to disorganized collagen deposition and impaired muscle function.

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Soft Tissue Injury Classification

A grading system used to classify soft tissue injuries based on the severity of the damage to muscle fibers, ranging from mild to severe.

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Grade III Muscle Tear

A type of soft tissue injury characterized by a complete tear of muscle fibers, often accompanied by muscle retraction.

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Plyometrics

Exercises that involve rapid, explosive movements and are used to improve power, speed, and agility. They are often used in rehabilitation to help athletes regain their pre-injury functional ability.

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What is Rhabdomyolysis?

A state with rapid breakdown of muscle cells that releases muscle components into the blood, potentially leading to kidney failure.

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What are Tendons and Ligaments?

Dense fibrous connective tissue that sustains high tensile loads and provides flexible support.

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Describe the Hemostasis phase of tendon healing.

The initial phase of tendon healing is characterized by a blood clot formation, followed by the creation of a fibrous network by fibrin and fibronectin.

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Describe the Inflammatory/Proliferative phase of tendon healing.

The proliferation phase of tendon healing involves the growth of new tissue, with fibroblasts and tenocytes forming granulation tissue.

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What is the importance of motion during tendon healing?

Tendon repair requires carefully controlled movement to optimize alignment and prevent scar tissue from forming.

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What is Chronic Tendinopathy?

Disordered tendon healing leads to degeneration of tendon tissue.

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How do extra-articular ligaments compare to intra-articular ligaments in terms of healing?

Extra-articular ligaments heal similar to tendon, however intra-articular ligaments can be more complex and may take longer to heal.

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Study Notes

Tissue Healing Overview

  • This lecture covers tissue healing, focusing on medical management for physical therapists.
  • Students will learn about physical stress theory, the body's responses to stress, and the stages of tissue healing.
  • They will also compare and contrast healing times in various tissues like muscle, tendon, ligament, and cartilage.
  • The lecture will cover appropriate physical therapy interventions.
  • It will further help students apply tissue healing concepts to improve musculoskeletal conditions.
  • This includes evaluating the pathology of tissue changes due to trauma and disease.

Pathology

  • Pathology refers to structural or functional changes triggered by disease or trauma in the body.
  • This is a pathway that begins with cell injury, followed by inflammation, and culminates in tissue healing.

Physical Stress Theory

  • Exposure to stress comprises the magnitude of force, time, and direction of force.
  • This theory proposes that tissue adaptation depends on the intensity, duration, and nature of the applied stress.
  • Physical stress theory outlines stages like atrophy, maintenance, hypertrophy, injury, and death, characterized by cumulative damage from traumas.

Other Factors Affecting Response to Stress

  • Age, past medical history (PMH), medications, activity level, obesity, nutrition, and body mechanics influence the body's response to stress and subsequent healing.
  • These factors play a crucial role in how the body adjusts and repairs itself.

How Does Stress Cause Injury?

  • High-magnitude stress over short periods can cause significant damage.
  • Low-magnitude stress repeatedly over a long time can also lead to injury.
  • Moderate-magnitude stress applied frequently can also contribute to injury.

Cell Injury Mechanisms

  • Cell injury can result from various factors, including infection, ischemia, immune response, genetic factors, nutritional deficiencies, chemical exposures, and temperature extremes.
  • This may also be caused by trauma.

Types of Cell Injury

  • Cell injury can be reversible, where the cell can recover, or irreversible, leading to cell death (necrosis).
  • The type of injury depends on the mechanism, severity, and intervention timescale.

Reversible Cell Injury

  • This involves sublethal transient alterations that the cell can adapt to.
  • These alterations may be followed by the removal of stressors leading to a return to normal structure and function.

Acute Reversible Cell Injury

  • Intracellular sodium (Na+) and calcium (Ca2+) levels increase, leading to swelling.
  • Mitochondria and endoplasmic reticulum may exhibit changes.
  • The pH of the cell can drop.
  • Removal of stressors reverses these processes effectively.

Chronic Sublethal Cell Injury

  • Prolonged sublethal injury can lead to possible adaptations such as hypertrophy, hyperplasia, metaplasia, or dysplasia.
  • The type of adaptation depends on stressors maintained.
  • The removal of stress or return to normal activities resolves the adaptation.

Irreversible Cell Injury-Necrosis

  • Cell death typically results in alterations in the nucleus, mitochondria, lysosomes, and the cell membrane.
  • Byproducts of cell death get released into the bloodstream, which can be assessed using blood tests.

Body's Response to Cell Injury- Inflammation

  • Inflammation follows cell injury, acting as a response to clear injured tissues and harmful substances for the body.

Functions of the Inflammatory Response

  • Inactivate the cause of injury (e.g., trauma, bacteria, toxins).
  • Breakdown and remove dead cells.
  • Begin tissue healing.

Inflammatory Reaction

  • The inflammatory response depends heavily on the amount, type, and severity of the injury.
  • The response involves innate immune response (e.g., neutrophils, macrophages).
  • Pro-inflammatory mediators like cytokines (e.g., interleukins, TNF), and growth factors play significant roles.

Acute vs Chronic Inflammation

  • Acute inflammation is characterized by rapid onset and short duration.
  • Chronic inflammation lasts longer and involves the accumulation of macrophages and lymphocytes.
  • Chronic inflammation's hallmarks may include hypervascularity and fibrosis resulting in tissue necrosis.

Causes of Chronic Inflammation

  • Chronic inflammation may arise from various causes, including undiagnosed harmful agents, extensive necrosis (e.g., burns), wide wound edges, inability to regenerate essential cells, frequent acute inflammatory episodes, and/or poor compliance.

Chemical Mediators of Inflammation

  • Histamine, platelet activating factor, and various arachidonic acid derivatives are pivotal players in the inflammatory pathway.
  • These mediators cause vascular changes (e.g., vasodilation, increased permeability), recruit inflammatory cells, and mediate pain, fever, and other symptoms.

Chemical Mediators of Inflammation: Cytokines

  • Cytokines, such as interleukins (ILs) and tumor necrosis factor (TNF), are crucial inflammatory molecules produced by leukocytes.
  • These influence various processes, including local and systemic effects, fever induction, increased metabolic responses, and hemodynamic changes.

Components of Tissue Healing-Collagen

  • Collagen is essential for structural support and tensile strength in various tissues.
  • The arrangement and type of collagen (I, II, III) impact tissue properties.
  • Type III collagen is pivotal during injury repair and undergoes replacement with Type I.

Components of Tissue Healing-Fibronectin, Proteoglycans, and Elastin

  • Fibronectin acts as a scaffold protein.
  • Proteoglycans and elastin hydrate and strengthen tissues.
  • They influence cell movement and tissue organization.

Factors Affecting Tissue Healing

  • Age, existing medical conditions (co-morbidities), medications, infection, activity level, nutrition, local blood supply, smoking, stress, and exercise impact healing outcomes.

Causes of Tissue Damage

  • Repetitive pathologic movement, overuse, trauma, and surgery are potential causes of tissue damage.

Stages of Tissue Healing

  • Tissue healing follows progressive stages.
  • Hemostasis and degeneration, inflammation, proliferation and migration, and maturation/remodeling are clearly defined stages.

Hemostasis and Degeneration Stage

  • The hemostasis stage involves limiting blood loss by closing off the injured area.
  • It triggers a cascade of coagulation pathways, culminating in clot formation to limit blood loss.
  • Damage to the endothelium triggers this response.

Plasma Protein Systems (Blood Coagulation)

  • Clotting systems form blood clots to stop bleeding and prevent infection spread.
  • Thrombin, fibrin, and other clotting factors enhance blood clot formation. Fibrin creates stronger clots, while thrombin activates platelets.

Plasma Protein Systems (Complement System and Kinins)

  • The complement system causes vasodilation, promotes leukocyte chemotaxis, and aids opsonization and lysis of pathogens.
  • Bradykinin is produced by the kinin system, causing vasodilation and pain.

Inflammation Stage

  • Inflammation involves clearing foreign bodies and harmful substances from the wound site.
  • Leukocytes/WBC, plasma proteins, and various other cells are vital.
  • This process typically lasts up to 5 days after injury.

Inflammation and Vascular Response

  • Local vasodilation and increased capillary permeability enable the movement of plasma proteins and WBCs to the injury site.
  • Edema and redness are common clinical signs.

Inflammatory Response (Leukocytes)

  • Leukocytes (WBCs) play a critical role during inflammation.
  • They attach to endothelial cells, migrate from blood vessels, follow chemical gradients to the injury site (chemotaxis), and remove debris/pathogens.
  • The process is crucial for an effective inflammatory response.

Inflammation: Role of Leukocytes

  • Neutrophils are initial immune cells that phagocytize debris.
  • Monocytes/macrophages arrive later and are vital for clearing and stimulating restorative immune responses.

Proliferation & Migration Stage

  • This stage, lasting 4-21 days post-injury, initiates tissue repair.
  • Fibroblasts move to the injury site, producing a scaffold using collagen and other ECM proteins.

Proliferation: Granulation Tissue

  • Granulation tissue forms, composed of fibroblasts and new blood vessels.
  • Fibroblasts transform into myofibroblasts, which aids in wound contraction.
  • Scar formation results, but these are not as strong as the original tissue.

Maturation/Remodeling Stage

  • Scar tissue formation matures (21 days to 1-2 years post-injury).
  • Type I collagen is the predominant type, increasing the scar's mechanical strength and organization.

Results of Tissue Healing

  • Scarring implies structural integrity restoration—but tissue properties may not reach pre-injury levels.
  • Regeneration implies tissue restoration to its original condition.
  • Final tissue structure is weaker than the original.

Rehabilitation Considerations (Inflammatory/Acute Stage)

  • Protection, elevation, avoidance of anti-inflammatories, and compression are initial stages in rehabilitation.
  • Managing edema and pain is important.
  • ROM of the affected area, and passive range of motion are recommended.

Rehabilitation Considerations (Proliferation/Subacute Stage)

  • Gradually increase stress to tissues to optimize collagen alignment.
  • Prevent scar contracture, encourage ROM, and introduce controlled strengthening exercises.
  • Gradual increase in muscle activity helps to restore strength and functional movements.

Rehabilitation Considerations (Maturation/Chronic Stage)

  • Rehabilitation aims to regain full pain-free motion.
  • Progressing to more extensive exercises involving more muscle involvement and force are common strategies for the maturation stage.

Tissue Repair: Skeletal Muscle

  • Muscle has the potential for regeneration.
  • Skeletal muscle recovery often includes myofibroblast activity, leading to scar tissue formation.
  • This stage typically involves a period of healing with potential for re-injury and the development of fibrosis.

Fibrosis

  • Fibrosis results from excess ECM material at the injury site.
  • Chronic inflammation, cytokine release, and excessive myofibroblast activity lead to disorganized, excessive collagen deposition.
  • Fibrosis hinders muscle regeneration.

Soft Tissue Injury Classification (Grades)

  • Soft tissue injuries are often categorized into grades based on the extent of tissue damage.
  • Grade I injuries are minimal, Grade II injuries exhibit moderate tearing, and Grade III injuries have significant, near-complete tearing.
  • Classification aids in treatment decisions (e.g., conservative vs. surgical).

Muscle Retraction

  • Muscle retraction is characterized by the inability to return the muscle to its normal resting position.
  • This condition generally indicates significant and possibly recurring muscle damage.

Tissue Repair: Skeletal Muscle (Satellite Cells)

  • Satellite cells are important for muscle healing.
  • They play a significant role in muscle regeneration because they proliferate, fuse, and synthesize muscle proteins.
  • They lead to the healing and repair process.

Skeletal Muscle: Rhabdomyolysis

  • Rhabdomyolysis involves severe muscle breakdown releasing cellular contents into the bloodstream.
  • Myoglobin is a major culprit.
  • This can cause severe complications, like kidney damage.
  • High-dose statins, ephedrine, and strenuous exercise may increase the risk of rhabdomyolysis. This process needs immediate medical attention.

Tissue Repair: Tendon/Ligament

  • Tendon and ligament healing is typically slower than muscle healing.
  • The low vascularity of these tissues limits healing rates.
  • Scar tissue formation, although weaker than the original structure, may require immobilization to avoid re-injury.
  • Specific mobilization strategies may be employed during rehabilitation to promote healing and prevent complications.

Chronic Tendinopathy

  • Chronic tendinopathy involves disordered tendon healing.
  • Macrophage accumulation, collagen degeneration and necrosis, irregular collagen orientation, and increased ground substance are common traits.
  • Specific treatment plans vary as a function of specific tendon types and the presenting injuries.

Tissue Repair: Ligament

  • Ligament healing is delayed due to limited vascularity.
  • Sprains or tears can compromise joint stability.
  • A longer rehabilitation period is necessary.

Tissue Repair: Cartilage

  • Cartilage has poor healing capabilities due to its avascular, alymphatic, and aneural nature.
  • This is another tissue that heals slowly because of limited blood supply.
  • Repair is often through scar tissue formation.

Tendon Injuries

  • Tendon rupture is often caused by exceeding physiologic limits.
  • Rapid force in an oblique direction is a common cause of rupture.
  • Tendinopathy is frequently triggered by overuse or repeated stress, leading to degeneration or damage.

Tissue Repair: Tendon

  • Tendon healing stages, hemostasis (immediate), inflammation/proliferation, and maturation, are all necessary for complete healing.
  • Type III collagen is initially deposited, gradually transitioning to Type I collagen.
  • Healing is potentially slower and requires proper immobilization strategies to avoid further tissue damage.

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