T1 L20: Pharmacological aspects of immunology 2: biological therapies (AMG)
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Questions and Answers

Which of the following biologics is a monoclonal antibody against B cells?

  • Infliximab
  • Etanercept
  • Adalimumab
  • Rituximab (correct)

    • Which of the following biologics is a T cell co-stimulation inhibitor?

  • Abatacept (correct)
  • Rituximab
  • Etanercept
  • Infliximab

    • Which of the following biologics is an IL-1R antagonist?

  • Anakinra (correct)
  • Infliximab
  • Etanercept
  • Rituximab

    • Which of the following biologics is a fully human anti-TNF-a monoclonal antibody?

    <p>Adalimumab</p> Signup and view all the answers

    Which of the following biologics is a PEGylated anti-TNF-a monoclonal antibody fragment?

    <p>Certolizumab pegol</p> Signup and view all the answers

    Which of the following biologics is administered as an intravenous infusion?

    <p>Infliximab</p> Signup and view all the answers

    Which of the following biologics is administered by subcutaneous injection twice a week or weekly?

    <p>Etanercept</p> Signup and view all the answers

    Which of the following is a synthetic DMARD used in the treatment of rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    Which of the following adverse effects is associated with methotrexate?

    <p>Nausea</p> Signup and view all the answers

    Which of the following JAK inhibitors selectively inhibits JAK1 and JAK3?

    <p>Tofacitinib</p> Signup and view all the answers

    Which of the following adverse effects is associated with tofacitinib?

    <p>Diarrhoea</p> Signup and view all the answers

    Which of the following biologic agents is recommended if a patient has failed to respond to treatment with at least two standard DMARDs?

    <p>Anti-TNF drugs</p> Signup and view all the answers

    Which of the following is a common adverse effect of anti-TNF drugs?

    <p>Dyslipidaemia</p> Signup and view all the answers

    Which of the following is a requirement for initiating biological therapy in rheumatoid arthritis?

    <p>Patient's DAS28 score is measured as 5.1 or over</p> Signup and view all the answers

    Which biologic agent is a monoclonal antibody against B cells?

    <p>Rituximab</p> Signup and view all the answers

    Which biologic agent is a T-cell co-stimulation inhibitor?

    <p>Abatacept</p> Signup and view all the answers

    Which biologic agents target IL-6R?

    <p>Tocilizumab and Sarilumab</p> Signup and view all the answers

    Which biologic agent is an IL-1R antagonist?

    <p>Anakinra</p> Signup and view all the answers

    Which mechanism is responsible for the depletion of B cells by rituximab?

    <p>Antibody-dependent cell mediated cytotoxicity</p> Signup and view all the answers

    Which biologic agent is a competitive inhibitor of CD28?

    <p>Abatacept</p> Signup and view all the answers

    Which biologic agent is used in the treatment of systemic juvenile idiopathic arthritis?

    <p>Tocilizumab</p> Signup and view all the answers

    Which biologic agent is administered as a subcutaneous injection?

    <p>Anakinra</p> Signup and view all the answers

    Which adverse effect is associated with biological therapies?

    <p>Increased risk of infections</p> Signup and view all the answers

    Which type of drugs slow the clinical and radiographic progression of rheumatoid arthritis?

    <p>Synthetic DMARDs: MTX, sulfasalazine, hydroxychloroquine, leflunomide</p> Signup and view all the answers

    Which drug is considered the first choice DMARD for rheumatoid arthritis?

    <p>Methotrexate (MTX)</p> Signup and view all the answers

    What is the function of Methotrexate (MTX) in the treatment of rheumatoid arthritis?

    <p>All of the above</p> Signup and view all the answers

    What is the recommended dosage range for Methotrexate (MTX) in the treatment of rheumatoid arthritis?

    <p>Between 7.5 and 25 mg weekly</p> Signup and view all the answers

    What is the role of Methotrexate (MTX) in combination therapies for rheumatoid arthritis?

    <p>All of the above</p> Signup and view all the answers

    What can be taken as a supplement to reduce the side-effects caused by folic acid depletion when taking Methotrexate (MTX)?

    <p>Folic acid</p> Signup and view all the answers

    What is the email address of Dr. Annamaria Gal?

    <p><a href="mailto:[email protected]">[email protected]</a></p> Signup and view all the answers

    Which of the following is a potential side effect of anti-inflammatory immunosuppressive drugs?

    <p>Increased risk of infections</p> Signup and view all the answers

    Which molecule is a central player in the pathogenesis of rheumatoid arthritis?

    <p>TNF</p> Signup and view all the answers

    Which drug is considered an anchor drug in the treatment of rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    Which biologic agent is a selective inhibitor of JAK1 and JAK3?

    <p>Baricitinib</p> Signup and view all the answers

    Which of the following is the main cause of rheumatoid arthritis?

    <p>Autoimmunity</p> Signup and view all the answers

    What is the role of anti-inflammatory drugs in the treatment of rheumatoid arthritis?

    <p>To reduce joint pain</p> Signup and view all the answers

    Which type of drugs are used to slow down the progression of rheumatoid arthritis?

    <p>DMARDs</p> Signup and view all the answers

    What is the recommended dosage range for Methotrexate (MTX) in the treatment of rheumatoid arthritis?

    <p>1-10 mg per week</p> Signup and view all the answers

    Which part of the chimeric antibody is mouse-derived?

    <p>Variable region</p> Signup and view all the answers

    Which part of the chimeric antibody is human-derived?

    <p>Constant region</p> Signup and view all the answers

    What is the mechanism by which the chimeric antibody eliminates TNF from the body?

    <p>Antibody-dependent cell-mediated cytotoxicity</p> Signup and view all the answers

    Which biologic therapy is recommended by the National Institute for Clinical Excellence (NICE) only when combined with Ms. Fixate Etanercept?

    <p>Infliximab</p> Signup and view all the answers

    Which pro-inflammatory cytokine is targeted by anti-TNF therapy in the treatment of rheumatoid arthritis?

    <p>IL-1</p> Signup and view all the answers

    What is the trade name of the anti-TNF antibody adalimumab?

    <p>HUMIRA</p> Signup and view all the answers

    Which drug has recently surpassed anti-TNF medications in terms of drug sales?

    <p>Pfizer vaccine</p> Signup and view all the answers

    Which pro-inflammatory cytokine has an important role in the mechanism of rheumatoid arthritis and is a potential target for therapy?

    <p>IL-1</p> Signup and view all the answers

    Which of the following is a biologic drug used in the treatment of rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    What is the normal range for erythrocyte sedimentation rate (ESR) in men?

    <p>1 to 50 millimeters per hour</p> Signup and view all the answers

    Which of the following biologics is a monoclonal antibody against B cells?

    <p>Rituximab</p> Signup and view all the answers

    Which biologic agent is a T-cell co-stimulation inhibitor?

    <p>Abatacept</p> Signup and view all the answers

    Which of the following drugs is a non-steroidal anti-inflammatory drug (NSAID)?

    <p>Ibuprofen</p> Signup and view all the answers

    What is the mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs)?

    <p>Blocking cyclooxygenase enzymes</p> Signup and view all the answers

    Which drug is considered the gold standard for treating rheumatoid arthritis?

    <p>Methotrexate</p> Signup and view all the answers

    Which category of drugs brought a dramatic increase in the quality of life for people with rheumatoid arthritis?

    <p>Biologics</p> Signup and view all the answers

    Which of the following vaccines can be administered to patients without posing a risk for increased risk of infections?

    <p>Polio vaccine</p> Signup and view all the answers

    What is the approach for administering anthrax vaccine to patients?

    <p>Administer for a prolonged time</p> Signup and view all the answers

    What percentage of patients report that their symptoms are not improved with anti-TNF therapy?

    <p>Up to 30%</p> Signup and view all the answers

    What is the main reason for patients not experiencing a biological effect from TNF antibodies?

    <p>Lack of responsiveness</p> Signup and view all the answers

    What are the other options that can be considered if patients can't tolerate anti-TNF therapy?

    <p>Other biologics</p> Signup and view all the answers

    What is the role of other biologics in the treatment of patients who don't respond to anti-TNF therapy?

    <p>To prolong the response to therapy</p> Signup and view all the answers

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