10 Questions
What is the primary goal of Quantitative Structure-Activity Relationships (QSAR)?
To find the best compound in the most efficient manner possible
What type of measurements are required for QSAR?
Quantitative measurements for biological and physicochemical properties
What is the significance of the partition coefficient (P) in QSAR?
It is a measure of the hydrophobicity of the molecule in octanol
What is the relationship between the activity of drugs and the partition coefficient (P)?
High P is associated with high hydrophobicity and high activity
What are the types of properties that are commonly studied in QSAR?
Hydrophobicity, electronic, and steric properties
What is the trend observed in the binding of drugs to serum albumin with respect to log P?
Binding increases as log P increases
What is the optimum value of log P for anaesthetic activity in different structural classes?
log P ≈ 2.3
What is the consequence of altering the log P value of drugs away from 2.0?
Decreased CNS side effects
What is the limitation of QSAR equations?
Only applicable to compounds in the same structural class
What is the relationship between log P and the concentration of drug required to achieve a defined level of biological activity?
Log (1/C) is inversely proportional to log P
This quiz covers the concept of QSAR, which involves relating biological activity to physicochemical parameters using mathematical formulas. Learn how to predict biological activity and find the best compounds efficiently. Understand the requirements and goals of QSAR.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
