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Questions and Answers
What is the purpose of Taft's Steric Factor (Es) in QSAR?
What is the purpose of Taft's Steric Factor (Es) in QSAR?
- To compare the rates of hydrolysis of substituted aliphatic esters against a standard ester
- To measure the rate of hydrolysis of substituted aliphatic esters
- To calculate the molar refractivity of a substituent
- To determine the steric effect of substituents on the transition state (correct)
What is the limitation of Taft's Steric Factor (Es)?
What is the limitation of Taft's Steric Factor (Es)?
- It is limited to substituents that interact sterically with the tetrahedral transition state (correct)
- It is limited to substituents that interact electrostatically with the transition state
- It is limited to substituents that interact with the transition state by hydrogen bonding
- It is limited to substituents that interact with the transition state by resonance
What is Molar Refractivity (MR) a measure of?
What is Molar Refractivity (MR) a measure of?
- A substituent's volume (correct)
- A substituent's refractive index
- A substituent's polarizability
- A substituent's molecular weight
What is the purpose of the Verloop Steric Parameter?
What is the purpose of the Verloop Steric Parameter?
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What is the software used to calculate the Verloop Steric Parameter?
What is the software used to calculate the Verloop Steric Parameter?
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What is an example of a substituent for which the Verloop Steric Parameter can be used?
What is an example of a substituent for which the Verloop Steric Parameter can be used?
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