QSAR Chapter 18: Steric Factors and Taft's Steric Factor
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Questions and Answers

What is the purpose of Taft's Steric Factor (Es) in QSAR?

  • To compare the rates of hydrolysis of substituted aliphatic esters against a standard ester
  • To measure the rate of hydrolysis of substituted aliphatic esters
  • To calculate the molar refractivity of a substituent
  • To determine the steric effect of substituents on the transition state (correct)

    • What is the limitation of Taft's Steric Factor (Es)?

  • It is limited to substituents that interact sterically with the tetrahedral transition state (correct)
  • It is limited to substituents that interact electrostatically with the transition state
  • It is limited to substituents that interact with the transition state by hydrogen bonding
  • It is limited to substituents that interact with the transition state by resonance

    • What is Molar Refractivity (MR) a measure of?

  • A substituent's volume (correct)
  • A substituent's refractive index
  • A substituent's polarizability
  • A substituent's molecular weight

    • What is the purpose of the Verloop Steric Parameter?

    <p>To give the dimensions of a substituent</p> Signup and view all the answers

    What is the software used to calculate the Verloop Steric Parameter?

    <p>STERIMOL</p> Signup and view all the answers

    What is an example of a substituent for which the Verloop Steric Parameter can be used?

    <p>Carboxylic acid</p> Signup and view all the answers

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