6 Questions
What is the purpose of Taft's Steric Factor (Es) in QSAR?
To determine the steric effect of substituents on the transition state
What is the limitation of Taft's Steric Factor (Es)?
It is limited to substituents that interact sterically with the tetrahedral transition state
What is Molar Refractivity (MR) a measure of?
A substituent's volume
What is the purpose of the Verloop Steric Parameter?
To give the dimensions of a substituent
What is the software used to calculate the Verloop Steric Parameter?
STERIMOL
What is an example of a substituent for which the Verloop Steric Parameter can be used?
Carboxylic acid
Test your knowledge of Quantitative Structure-Activity Relationships (QSAR) in Chapter 18, focusing on steric factors and Taft's Steric Factor (Es) in organic chemistry. Learn about the measurement of Es through hydrolysis rates of substituted aliphatic esters. Assess your understanding of the limitations of this method.
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