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QSAR Chapter 18: Hydrophobicity of Substituents
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QSAR Chapter 18: Hydrophobicity of Substituents

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Questions and Answers

What is the measure of a substituent's hydrophobicity relative to hydrogen?

  • log P
  • P
  • QSAR
  • π (correct)

    • What is the purpose of QSAR equation?

  • To calculate the log P value of a molecule
  • To identify regions of a molecule that interact with hydrophobic regions in the binding site (correct)
  • To determine the importance of a molecule's overall hydrophobicity
  • To measure the overall hydrophobicity of a molecule

    • What is the value of π for the substituent CH3 in aliphatic substituents?

  • 0.50 (correct)
  • 1.68
  • 0.52
  • -1.16

    • What does a positive value of π imply about a substituent?

    <p>The substituent is more hydrophobic than hydrogen</p> Signup and view all the answers

    How is the logarithmic value of the partition coefficient (log P) related to π?

    <p>log P is calculated using π values</p> Signup and view all the answers

    What is the role of log P in a QSAR equation?

    <p>It measures the importance of a molecule's overall hydrophobicity</p> Signup and view all the answers

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