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Questions and Answers
Which form of D-glucose predominates in solution due to reduced steric hindrances?
Which form of D-glucose predominates in solution due to reduced steric hindrances?
What is the ratio of β to α anomer conformations for D-glucose in an equilibrium solution?
What is the ratio of β to α anomer conformations for D-glucose in an equilibrium solution?
Which of the following best describes why D-glucose is an important fuel for most organisms?
Which of the following best describes why D-glucose is an important fuel for most organisms?
Which statement about reducing sugars is correct?
Which statement about reducing sugars is correct?
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What happens during mutarotation of cyclic sugars?
What happens during mutarotation of cyclic sugars?
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Which form of glucose does not react with oxidizing agents?
Which form of glucose does not react with oxidizing agents?
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What is true about the chair and boat forms of β-D-glucose?
What is true about the chair and boat forms of β-D-glucose?
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Which of the following sugars is a known reducing sugar?
Which of the following sugars is a known reducing sugar?
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What is the empirical formula for carbohydrates?
What is the empirical formula for carbohydrates?
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Which of the following describes the structural classification of monosaccharides?
Which of the following describes the structural classification of monosaccharides?
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What is a constitutional isomer?
What is a constitutional isomer?
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How many carbon atoms can monosaccharides contain?
How many carbon atoms can monosaccharides contain?
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Which type of monosaccharide is classified as a pentose?
Which type of monosaccharide is classified as a pentose?
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What term is used to describe sugars that differ in configuration only at a single asymmetric center?
What term is used to describe sugars that differ in configuration only at a single asymmetric center?
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What happens to an aldehyde when it reacts with an alcohol?
What happens to an aldehyde when it reacts with an alcohol?
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What is the role of the anomeric carbon in glucose?
What is the role of the anomeric carbon in glucose?
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Which of the following terms refers to diastereoisomers that are not mirror images of each other?
Which of the following terms refers to diastereoisomers that are not mirror images of each other?
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What type of cyclic structure is formed by sugars that resemble furan?
What type of cyclic structure is formed by sugars that resemble furan?
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Study Notes
Carbohydrates and Glycoproteins
- Carbohydrates are carbon-based molecules with a high proportion of hydroxyl groups.
- Their empirical formula is (CH2O)n, but they can have additional groups or modifications.
- They are better described as polyhydroxy aldehydes and ketones.
- Monosaccharides are the simplest carbohydrates and consist of three to seven carbons.
- They are also called simple sugars.
Monosaccharide Nomenclature
- Nomenclature is based on carbon chain length:
- Three carbons: trioses
- Four carbons: tetroses
- Five carbons: pentoses
- Six carbons: hexoses
- Seven carbons: heptoses
- Nomenclature is also based on the identity of the most oxidized group:
- Keto group: ketose
- Aldehyde group: aldose
Isomers
- Constitutional Isomers: Molecules with identical molecular formulas but differ in the order of their atoms.
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Stereoisomers: Molecules that differ in spatial arrangement but not bonding order.
- They have either D or L configuration.
- Can be enantiomers (mirror images of each other) or diastereoisomers (not mirror images of each other).
- The number of possible stereoisomers is 2n, where n is the number of asymmetric carbon atoms.
Common Monosaccharides
- Epimers: Sugars that are diastereoisomers differing in configuration only at a single asymmetric center.
Cyclic Forms of Monosaccharides
- Most monosaccharides exist primarily in their ring forms.
- An aldehyde can react with an alcohol to form a hemiacetal.
- A ketone can react with an alcohol to form a hemiketal.
Pyranose Formation
- Occurs when a six-membered ring is formed.
- Named after the compound pyran.
Furanose Formation
- Occurs when a five-membered ring is formed.
- Named after the compound furan.
Anomers of Glucose
- Anomer: A diastereoisomeric form of sugars that forms when a cyclic hemiacetal forms and an additional asymmetric center is created.
- In glucose, C-1 (the anomeric carbon atom) becomes an asymmetric center, forming two ring structures:
- α-D-glucopyranose: Hydroxyl group attached to C-1 is on the opposite side of the ring as C-6.
- β-D-glucopyranose: Hydroxyl group attached to C-1 is on the same side of the ring as C-6.
D-Fructose Ring Structures
- C-2 is the anomeric carbon atom.
- The pyranose form predominates in solution due to reduced steric hindrances.
- The furanose form predominates in fructose derivatives.
Chair and Boat Forms of β-D-Glucose
- The chair form predominates because all axial positions are occupied by hydrogens.
- The boat form is disfavored because it is sterically hindered.
D-Glucose as a Fuel
- Blood Sugar: D-glucose circulating in the blood.
- Used as the sole fuel by the brain (in non-starvation conditions) and red blood cells.
- Potential reasons why D-glucose is an important fuel:
- Glucose is formed from formaldehyde under prebiotic conditions and may have been available as a fuel source for primitive biochemical systems.
- It is relatively inert.
- The most stable ring structure is β-D-glucopyranose.
Solutions of Glucose
- Two anomeric forms (α and β) are in equilibrium that passes through the open-chain form.
- The β anomer is more stable in solution.
Reducing Sugars
-
Reducing Sugars: Sugars that react with oxidizing agents.
- All monosaccharides can adopt linear structures in solution.
- Non-Reducing Sugars: Sugars that do not react with oxidizing agents.
- Fehling's solution: Solutions of Cu2+ used to test for the presence of reducing sugars.
Mutarotation
- The change in the specific rotation of a cyclic sugar as it reaches an equilibrium between its alpha and beta anomeric forms.
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