2.3
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Questions and Answers

What is a major determinant of Pulmonary Vascular Resistance (PVR)?

  • Heart rate
  • Blood flow rate
  • Transmural pressure difference (correct)
  • Systemic blood pressure

What allows for less resistance to flow in the pulmonary circulation compared to systemic circulation?

  • Heart rate
  • Vessel diameter
  • Transmural pressure difference (correct)
  • Blood viscosity

What type of pressure drop is observed in the pulmonary circulation from the pulmonary artery to the left atrium?

  • ~ 100 mmHg
  • ~ 150 mmHg
  • ~ 50 mmHg
  • ~ 10 mmHg (correct)

What plays a major role in determining Pulmonary Vascular Resistance (PVR) besides active smooth muscle contraction?

<p>Passive factors (A)</p> Signup and view all the answers

How does Pulmonary Vascular Resistance (PVR) compare to Systemic Vascular Resistance (SVR)?

<p>PVR is 1/10 of SVR (A)</p> Signup and view all the answers

In which zone of the lung does capillary pressure never exceed alveolar pressure?

<p>Zone 1 (D)</p> Signup and view all the answers

What characterizes Zone 2 of the lung in terms of blood flow?

<p>Intermittent blood flow (D)</p> Signup and view all the answers

How is pulmonary capillary wedge pressure (PCWP) estimated?

<p>Similar to left atrial pressure (A)</p> Signup and view all the answers

What does a Swan-Ganz catheter balloon tip floated into the pulmonary artery estimate?

<p>Pulmonary capillary wedge pressure (PCWP) (D)</p> Signup and view all the answers

During exercise, which lung zone experiences continuous blood flow?

<p>Zone 3 (D)</p> Signup and view all the answers

What is the primary function of pulmonary circulation?

<p>Gas exchange (D)</p> Signup and view all the answers

How many pulmonary capillaries supply the alveoli in the lungs?

<p>280 billion (C)</p> Signup and view all the answers

Where do lung structures distal to terminal bronchioles receive oxygen from?

<p>Alveolar air (D)</p> Signup and view all the answers

What is the average diameter of pulmonary capillaries?

<p>~6 um (A)</p> Signup and view all the answers

In the absence of pulmonary circulation, what can serve as collateral circulation for gas exchange in the airways?

<p>Bronchial veins (D)</p> Signup and view all the answers

What is the purpose of Hypoxic Pulmonary Vasoconstriction (HPV)?

<p>To divert blood away from poorly ventilated alveoli (C)</p> Signup and view all the answers

What happens when the PO2 of alveoli decreases in the context of Hypoxic Pulmonary Vasoconstriction?

<p>Smooth muscle in arterioles contracts causing vasoconstriction (A)</p> Signup and view all the answers

What does Hypoxic Pulmonary Vasoconstriction aim to mitigate?

<p>Shunt (A)</p> Signup and view all the answers

How does Hypoxic Pulmonary Vasoconstriction affect the resistance to blood flow in hypoventilated alveoli?

<p>Increases resistance to blood flow (A)</p> Signup and view all the answers

What is the volume and distributive aspect of pulmonary circulation when lying down?

<p>Increased blood flow per unit volume in gravity-dependent lung regions (B)</p> Signup and view all the answers

What is the term for the phenomenon where blood flow is directed away from poorly ventilated areas of the lung to well-ventilated regions?

<p>Hypoxic pulmonary vasoconstriction (D)</p> Signup and view all the answers

In pulmonary circulation, what is the main determinant of arterial pressure?

<p>The cardiac output from the left ventricle (B)</p> Signup and view all the answers

How does increased cardiac output affect pulmonary vessels?

<p>Decreases pulmonary vascular resistance (A)</p> Signup and view all the answers

What is the term for the condition where fluid accumulates in the lungs impairing gas exchange?

<p>Pulmonary edema (B)</p> Signup and view all the answers

How does the position of vessels in the lung affect their resistance?

<p>Vessels closer to the pleura have lower resistance (A)</p> Signup and view all the answers

What happens to the alveolar capillary walls when blood volume inside increases?

<p>They distend (D)</p> Signup and view all the answers

At high lung volumes, which of the following statements is true regarding pulmonary vascular resistance?

<p>Alveolar vessel resistance increases (A)</p> Signup and view all the answers

What happens to pulmonary vascular resistance with increased cardiac output?

<p>Pulmonary vascular resistance decreases (B)</p> Signup and view all the answers

How does recruitment affect pulmonary vascular resistance?

<p>Opens closed capillaries (A)</p> Signup and view all the answers

During exercise, what contributes to the decrease in pulmonary vascular resistance?

<p>Distention of blood vessels (C)</p> Signup and view all the answers

How does positive pressure ventilation (PPV) affect pulmonary blood flow?

<p>Decreases pulmonary blood flow by reducing right ventricular preload (A)</p> Signup and view all the answers

What is the main effect of PPV on the afterload of the right ventricle?

<p>Increases afterload by elevating PVR (C)</p> Signup and view all the answers

Which condition is likely to be associated with an increase in Zone 1 in the lungs?

<p>Positive alveolar pressures and decreased venous return (D)</p> Signup and view all the answers

What effect does positive pressure ventilation, especially with PEEP, have on low ventilation-perfusion ratios (shunt)?

<p>Decreases low ventilation-perfusion ratios (D)</p> Signup and view all the answers

How does a decrease in blood volume to the left heart impact left ventricular filling and stroke volume?

<p>Decreases left ventricular filling and stroke volume (C)</p> Signup and view all the answers

What happens to intrathoracic pressure during positive pressure ventilation?

<p>Elevates intrathoracic pressure (C)</p> Signup and view all the answers

How does resistance to pulmonary blood vessels change during inspiration?

<p>Increases during inspiration (D)</p> Signup and view all the answers

What is the effect of negative-pressure (eupnea) breathing on LV filling and stroke volume?

<p>Decreases LV filling and stroke volume (A)</p> Signup and view all the answers

How does decreased CO affect total thoracic blood volume?

<p>Decreases total thoracic blood volume (D)</p> Signup and view all the answers

What is the impact of decreased RV filling & SV on RVCO?

<p>Decreases RVCO (A)</p> Signup and view all the answers

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