Pulmonary Hypertension: Definition and Diagnosis

Which organization does C.P. Denton NOT report receiving consultancy fees from?

What type of conflict of interest does S. Gu explicitly report?

Which award is associated with S. Gu's reported grants?

Which of the following individuals reports receiving stock or stock options?

D.Khanna's consultancy fees include which of the following companies?

What is one of the primary focuses of the systematic review related to pulmonary arterial hypertension?

What type of pulmonary hypertension is primarily focused on in the COMPERA analysis?

Which of the following studies discusses the effects of exercise on pulmonary arterial wedge pressure?

What is a key outcome measured in the clinical relevance of fluid challenge in pulmonary hypertension evaluations?

What common characteristic is explored among elderly patients with idiopathic pulmonary arterial hypertension in the COMPERA registry?

Pulmonary Hypertension Definition, Classification, and Diagnosis

Pulmonary Hypertension (PH): A haemodynamic condition characterized by elevated mean pulmonary arterial pressure (mPAP) >20 mmHg, measured by right heart catheterization.
Pre-capillary PH: mPAP >20 mmHg, elevated pulmonary vascular resistance (PVR) >2 Wood Units (WU), and pulmonary arterial wedge pressure (PAWP) ≤15 mmHg. Characterizes conditions where the problem is before the capillaries.
Isolated post-capillary PH (ipcPH): mPAP >20 mmHg, PAWP >15 mmHg, and PVR ≤2 WU. Suggests left heart disease.
Combined post- and pre-capillary PH (cpcPH): mPAP >20 mmHg, PAWP >15 mmHg, and PVR >2 WU. Indicates problems in both the capillaries and the area before it.
Exercise PH: mPAP at rest is normal, but increases abnormally during exercise (mPAP/cardiac output slope >3 mmHg/L/min). Demonstrates a response to exertion.

Clinical Classification of PH

The core structure of the clinical classification of PH, including five major groups, is retained.
Key changes include: the re-introduction of "long-term responders to calcium channel blockers" in idiopathic pulmonary arterial hypertension, subgroups within group 2 PH, and a shift to classifying group 3 PH subgroups based on pulmonary diseases instead of functional abnormalities.
The diagnostic approach focuses on identifying patients requiring referral to a PH center for invasive evaluation, with priority given to patients with potential severe pulmonary vascular disease or right-heart failure signs.

This quiz covers the definitions, classifications, and diagnostic criteria for pulmonary hypertension (PH). Learn about pre-capillary, post-capillary, and exercise PH, as well as the hemodynamic parameters involved. Test your understanding of this important cardiovascular condition.