PSW 168 Final Exam Review

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Questions and Answers

In the etiology of Type 1 Diabetes Mellitus (T1DM), which of the following immunological mechanisms is most critically implicated in the pathogenesis?

  • Selective apoptosis of pancreatic beta cells mediated by autoreactive cytotoxic T lymphocytes (CTLs) recognizing beta-cell specific antigens presented on MHC class I molecules. (correct)
  • Aberrant class switching of B cells producing IgE antibodies against pancreatic beta cells, leading to mast cell degranulation and localized inflammation.
  • Deposition of immune complexes composed of insulin and anti-insulin antibodies in the pancreatic interstitium, activating the complement cascade and inducing tissue damage.
  • Dysregulation of regulatory T cells (Tregs) in the thymus, resulting in failure to establish central tolerance to islet antigens and subsequent autoimmune destruction.

Considering the pleiotropic effects of insulin, which of the following scenarios would most accurately exemplify the pathophysiological cascade initiated by insulin deficiency in Type 1 diabetes mellitus?

  • Suppressed ketogenesis and augmented protein synthesis, facilitated by compensatory upregulation of insulin-independent glucose transporters in muscle tissues.
  • Stimulation of lipoprotein lipase activity, causing excessive triglyceride synthesis and hyperlipidemia, offset by increased insulin sensitivity in adipocytes.
  • Increased hepatic glycogenesis coupled with enhanced peripheral glucose uptake, leading to rapid glycogen storage and consequent hypoglycemia.
  • Unrestrained hepatic gluconeogenesis and glycogenolysis, alongside impaired peripheral glucose utilization, culminating in hyperglycemia and osmotic diuresis. (correct)

In the context of sick day management for individuals with Type 1 diabetes, which of the following interventions requires the most critical and nuanced clinical judgment from a Personal Support Worker (PSW)?

  • Administering a fixed 'sick day' bolus dose of rapid-acting insulin, irrespective of current blood glucose levels, to counteract anticipated insulin resistance.
  • Withholding insulin injections if the individual is unable to maintain their usual dietary intake due to nausea or vomiting, to avoid potential hypoglycemic episodes.
  • Frequent monitoring of blood glucose and ketone levels, with adjustments to insulin dosages based on trends and individual responses, while maintaining hydration. (correct)
  • Forcing consumption of carbohydrate-rich fluids (e.g., juice, soda) to prevent hypoglycemia, even in the presence of elevated blood glucose and urinary ketones.

Considering the multifaceted etiology of Parkinson's disease, which of the following pathological processes most precisely characterizes the underlying neurodegenerative mechanism?

<p>Prion-like propagation of misfolded alpha-synuclein protein aggregates, resulting in selective dopaminergic neuron loss in the substantia nigra pars compacta. (A)</p> Signup and view all the answers

In the rehabilitative care of a patient post-stroke experiencing hemiplegia, which of the following therapeutic strategies would be most crucial for promoting neuroplasticity and functional recovery of the affected limb?

<p>Implementing constraint-induced movement therapy (CIMT) to force use of the paretic limb while restricting movement of the unaffected limb. (D)</p> Signup and view all the answers

Considering the complexities of HIV transmission dynamics, which of the following risk scenarios presents the highest per-act probability of HIV acquisition, assuming all individuals involved are not on pre-exposure prophylaxis (PrEP) or antiretroviral therapy (ART)?

<p>Insertive vaginal sex (man on top) with an HIV-positive partner who has a high viral load and the receiving partner is experiencing an active bacterial vaginosis. (C)</p> Signup and view all the answers

Which of the following mechanisms most accurately details the pathophysiology of Celiac disease in response to gluten exposure?

<p>A Type IV hypersensitivity reaction driven by gluten-specific CD4+ T helper cells activating macrophages and inducing chronic inflammation and villous atrophy. (D)</p> Signup and view all the answers

In the context of managing Meniere's disease, which of the following interventions demonstrates the most comprehensive approach to minimizing the risk of falls during an acute episode of vertigo?

<p>Instructing the individual to immediately lie down in a darkened, quiet room with their eyes closed and avoid any sudden movements or changes in head position. (D)</p> Signup and view all the answers

Among individuals diagnosed with hyperthyroidism, which of the following clinical manifestations most directly results from the effects of elevated thyroid hormone levels on cardiac electrophysiology and myocardial function?

<p>Onset of atrial fibrillation (AF) due to increased sensitivity of atrial myocytes to adrenergic stimulation, leading to shortened refractory periods and re-entrant circuits. (B)</p> Signup and view all the answers

In the context of urinary system physiology, what compensatory mechanism is most critically impaired in individuals with advanced diabetic nephropathy, leading to an inability to effectively regulate fluid and electrolyte balance?

<p>Impaired glomerular filtration rate (GFR) and tubular function, diminishing the kidney's capacity to concentrate urine and excrete excess solutes and fluid. (A)</p> Signup and view all the answers

Flashcards

Celiac Disease

Inborn metabolic disorder where the person is unable to tolerate gluten protein, affects adults and children.

Ileostomy

Surgically created opening between ileum and abdominal wall, with entire colon removed and liquid drainage.

Diabetes

Disorder in which the body cannot produce or properly use insulin, leading to hyperglycemia if untreated.

Hyperthyroidism

A condition in which the thyroid gland is overactive, producing too much thyroid hormone and speeding up body functions.

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Hypothyroidism

A condition caused by an underactive thyroid gland, leading to decreased thyroid hormone production and slowed body processes.

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Hyperglycemia

A condition where sugar builds up in the blood because it cannot get into the cells, often due to insulin deficiency.

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Polydipsia

Occurs when water follows glucose into the urine and causes extreme thirst.

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Retinopathy

Damage to the retina caused by high blood sugar due to diabetes, results in impairment or vision loss.

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Parkinson's Disease

A neurodegenerative disease where dopamine-producing cells die, resulting in tremor, stiffness, and slow movements.

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Hemiplegia

Paralysis of one side of the body, often resulting from a stroke.

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Study Notes

  • Final Exam Review for PSW 168

Celiac Disease

  • It is an inborn metabolic disorder where the individual cannot tolerate gluten protein.
  • Adults and children can be affected.
  • Symptoms include abdominal distension, vomiting, very large amounts of diarrhea, muscle wasting, and lethargy.
  • A gluten-free diet is the most effective treatment.

Ileostomy

  • It is a surgically created opening between the ileum and the abdominal wall.
  • The entire colon is removed.
  • Liquid drainage occurs.

The Urinary System

  • The components kidneys, ureter, bladder, sphincter and urethra are involved.

PSW Role

  • Measures and records hourly urine output.
  • Records intake and restricts fluids.
  • Monitors daily weight.
  • Provides frequent oral care.
  • Implements infection prevention techniques.
  • Prevents bed rest complications.

Diabetes

  • It is a disorder in which the body cannot produce or properly use insulin.
  • Insulin is a hormone secreted by the pancreas.
  • Insulin is needed for the appropriate use of sugar (glucose).
  • Hyperglycemia occurs when there is not enough insulin in the body.
  • If the cells do not have sugar for energy they cannot perform their functions.
  • Untreated diabetes can lead to long-term complications.
  • Severe hyperglycemia can be life-threatening.

What is Occurring in Diabetes?

  • There is a deficiency of insulin available to cells.
  • Sugar builds up in the blood, resulting in hyperglycemia.
  • The kidney's ability to conserve glucose is exceeded, and excess sugar is excreted in urine, a condition called glycosuria.
  • Osmosis causes water to follow glucose into the urine which results in extreme thirst, called polydipsia.
  • When the body shifts from using carbohydrates to using fats for energy it causes weight loss, extreme hunger, called polyphagia.
  • Excessive urination, micturition, and voiding is called polyuria.
  • When fat is metabolized, it results in the production of ketones, called ketoacidosis.
  • Nutritional and energy requirements determine diabetes meal planning.

Hyperthyroidism

  • It is an overactive thyroid gland that causes too much thyroid hormone to be produced.
  • All other bodily functions speed up.
  • Signs and symptoms of hyperthyroidism include weight loss, increased hunger, hyperactivity, palpitations, nausea, vomiting, irritability, and depression.
  • Treatments include surgical removal of some or all of the thyroid gland.
  • The administration of one dose of radioactive iodine destroys some of the thyroid cells.
  • Medications can inhibit the production of the thyroid hormone.

Hypothyroidism

  • It is caused by an underactive thyroid gland.
  • A decreased production of thyroid hormones = body process slows.
  • Signs and symptoms of hypothyroidism: weight gain, impaired memory, fatigue, sluggishness, irritability, constipation and slow heart rate.
  • Treatment includes a thyroid supplement.

IDDM (Insulin-Dependent Diabetes Mellitus), Type 1

  • Occurs most often in children and young adults.
  • The pancreas does not produce insulin.
  • Leads to severe hyperglycemia.
  • Develops early symptoms of the disease.
  • Treatment: Daily insulin injections.

NIDDM (Non-Insulin-Dependent Diabetes Mellitus), Type 2

  • It is the most common type of diabetes.
  • Usually occurs after the age of 40, but is increasingly seen in younger individuals due to increasing rates of obesity.
  • The pancreas does not produce enough insulin, or the body does not effectively use the insulin produced.
  • Treatment: Diet and exercise, oral medications and insulin may be needed sometimes.

Hypoglycemia (Low Blood Sugar)

  • Causes of Hypoglycemia:
    • Too much insulin or diabetes medication.
    • Omitting or delaying a meal or snack.
    • Eating too little food.
    • Too much exercise.
    • Vomiting.
  • Signs and Symptoms of Hypoglycemia:
    • Hunger, weakness.
    • Trembling, shakiness.
    • Sweating.
    • Headache, dizziness.
    • Faintness, irritability, anxiety.
    • Disorientation, confusion.
    • Rapid pulse & rapid shallow breathing.
    • Changes in vision.
    • Cold, clammy skin.
    • Unconsciousness.
    • Convulsions.

Hyperglycemia (High Blood Sugar)

  • Causes of Hyperglycemia:
    • Undiagnosed diabetes.
    • Not enough insulin or diabetes medication.
    • Overeating or eating the wrong kind of foods.
    • Too little exercise.
    • Stress: physical or emotional.
  • Signs and Symptoms of Hyperglycemia:
    • Tiredness or fatigue.
    • Hunger, thirst.
    • Frequent urination.
    • Leg cramps, blurred vision.
    • Dry, itchy skin.
    • Flulike achiness.
    • Headache, flushed face.
    • Rapid, weak pulse.
    • Low blood pressure.
    • Sweet breath odor.
    • Slow, deep & labored breathing.
    • Confusion, nausea & vomitting.
    • LOC, convulsions.

Foot Care

  • It is very very important to observe your client's feet every day.
  • Especially for a diabetic clients due to Neuropathy.
  • Foot and leg wounds have very serious consequences like infections and gangrene.

Retinopathy

  • Retinopathy is a disease of the retina which results in impairment or loss of vision.
  • It is caused by high blood sugar due to diabetes.

Role of the PSW

  • Report signs and symptoms of hyperglycemia or hypoglycemia to your supervisor immediately.
  • May make meals and needs to follow a diabetic meal plan.
  • Serve meals and snacks on time.
  • Records the amount of food the client eats at every meal and snack.
  • Calories not consumed at a meal or snack must be replaced during the day or a reaction may occur.

The Neuro System

  • Includes the brain and spinal cord.

Scalp injuries:

  • This includes lacerations (cuts).
  • Hematoma (collection of blood-blood blister).
  • Contusion (bruise).
  • Abrasion to the skin (scrape).

Concussion

  • Signs of a concussion include:
    • Potential loss of consciousness > 5 min.
    • Not remembering what caused the injury to the head.
    • Dizziness.
    • Blurry vision.
    • Headache.
    • Nausea and/or vomiting.
    • Unclear thinking processes-confusion.
    • Repeating phrases, for example, "What happened?".

Cerebral Palsy

  • It is a disorder affecting muscle control and is progressive.
  • Causes include injury, abnormality in the motor region of the brain (cerebral) and lack of oxygen to the brain.

Parkinson's Disease

  • It is a neurodegenerative disease.
  • Movement is normally controlled by dopamine: chemical carries signals between nerves in the brain.
  • When dopamine-producing cells die, symptoms of Parkinson's appear.
  • Sings: Impaired speech that is monotonous and soft.
  • Loss of automatic movements like fixed staring expression or an unblinking eyes, lack of animation when speaking or a masked face.
  • Therapy includes physical therapy to improves mobility, flexibility, balance as well as speech therapy and ocupational therapy to help with ADL's.
  • Exercise such as walking, swimming, gardening, and dancing helps client.

Falls

  • Precautions to avoid includes wearing walking shoes (not running shoes).
  • The person should also check posture (stand straight, feet 8-10 inches apart) if shuffling.
  • If a person gets stuck in place, also called freezing, they should rock side to side or pretend you're stepping over an object.
  • A client is encouraged to take long steps and exaggerate lifting legs and swing arms.

Avoiding Falls

  • Practice Tai Chi: may improve balance.
  • Remove throw rugs.
  • Install handrails.
  • Grab bars in the bathroom and tub.
  • Carry a cordless phone.

Therapy

  • Improves mobility, flexibility, balance.
  • Can involve speech therapy and occupational therapy too.
  • Beneficial exercise includes walking, swimming, gardening, and dancing.

Stroke - CVA (Cerebral Vascular Accident)

  • It is a sudden loss of brain function
  • Causes: interruption of blood flow to brain (ischemic), rupture of brain blood vessels (hemorrhagic) or death of neurons.

Transient Ischemic Attack (TIA)

  • Referred to as a "mini-stroke."
  • It is a temporary decrease in blood flow to the brain.
  • It is a warning sign of increased risk of stroke.
  • A patient may not know that TIA's are occuring.

Effects of a Stroke

  • Hemiplegia: paralysis of one side of the body.
  • Loss of facial muscle control.
  • Changes emotions.
  • Dysphasia: difficulty swallowing.
  • Dimmed vision or loss of vision.
  • Inability to speak or understand others.
  • Changes in sight, touch, movement, & thought.
  • Urinary frequency, urgency, or incontinence.
  • Aphasia: loss of speech.

Rehabilitation

  • Goals are to restore function to former levels.
  • To improve functional abilities.
  • To learn new skills.
  • To prevent further disability and illness.

HIV Infection

  • HIV is spread when there is exchange of certain body fluids, this includes seminal fluid, vaginal fluid, breast milk and infected blood.
  • High Risk Activities:
    • Vaginal or anal sex without a condom.
    • Sharing used needles includes tattooing or body piercing.
    • HIV +ve mom breast feeding.
    • Re-using condoms.
    • Unsafe sex under the influence of drugs/alcohol.

Hepatitis

  • Hepatitis A, B, and C are the most common types.

Influenza

  • Respiratory tract infection caused by a virus.
  • The flu season is from November - May.
  • It is spread by droplet infection.
  • It is highly contagious with a sudden onset.

Tuberculosis

  • Signs and symptoms include : positive skin test, fever, chills, night sweats, weight loss, SOB, coughing, hemoptysis.
  • Diagnostic tests: Skin Test, Chest X-ray, Sputum Samples.

Ménière’s Disease

  • There is an increase of fluid in the inner ear causing pressure in the middle ear, usually one ear is affected.
  • Symptoms include vertigo, tinnitus, hearing loss, pain/pressure in the affected ear, severe dizziness(nausea/vomiting).
  • Safety measures are needed during vertigo, fall risk so the resident should lie down.

Vision Impairment

  • Differentiate Glaucoma from Cataracts.
  • Also called AMD or ARMD
  • It blurs central vision and causes damage to the macula located in the centre of the retina.
  • The macula is responsible for seeing fine details.

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