Propofol Flashcards

Questions and Answers

What is the trade name for propofol?

Anesyl

Hypnex

Sedetol

Diprivan (correct)

What class does propofol belong to?

Antibiotic

Anesthetic, sedative-hypnotic (correct)

Antidepressant

Analgesic

What is the supplied concentration of propofol?

10 mg/mL in 20 mL, 50 mL and 100 mL vials

What are the actions of propofol?

Produces dose-dependent CNS depression similar to benzodiazepines and barbiturates. Signup and view all the answers

What are the indications for using propofol?

Induction and maintenance of general anesthesia in mechanically ventilated patients. Signup and view all the answers

What is the induction dose of propofol for adults?

2-2.5 mg/kg; lower end for those over 55 is 2 mg/kg. Signup and view all the answers

What is the repeat induction dose for adults using propofol?

50% of the induction dose in 10 minutes. Signup and view all the answers

What is the infusion dosage of propofol for adults?

100-200 mcg/kg/min, increase by 5 until effect achieved. Signup and view all the answers

What are the contraindications for using propofol?

Hypovolemia, hypersensitivity to the drug, increased ICP, pregnancy. Signup and view all the answers

What precautions should be taken when administering propofol?

Monitor for hypotension and use cautiously in elderly or impaired patients. Signup and view all the answers

What are the characteristics of propofol regarding solubility?

It is highly lipid soluble and nearly insoluble in water. Signup and view all the answers

What is the onset time for propofol when administered IV?

1-2 minutes Signup and view all the answers

What is the duration of effect for propofol?

3-5 minutes Signup and view all the answers

Study Notes

Propofol Overview

Trade Name: Diprivan
Class: Anesthetic and sedative-hypnotic, inducing central nervous system depression.

Formulation and Supply

Supplied as a 10 mg/mL solution in vial sizes of 20 mL, 50 mL, and 100 mL.

Mechanism of Action

Produces dose-dependent CNS depression akin to benzodiazepines and barbiturates.
Maintains anesthesia through careful titration of doses.

Clinical Indications

Indicated for the induction and maintenance of general anesthesia, particularly in mechanically ventilated patients.

Dosage Guidelines

Adults:
- Induction: 2-2.5 mg/kg (lower end for patients over 55).
- Repeat: 50% of the initial dose in 10 minutes.
- Infusion: Start at 100-200 mcg/kg/min, adjusting by 5 mcg/kg/min until desired effect is achieved.
- Light Sedation for ICU: 5-10 mcg/kg/min.
Elderly/Debilitated Patients:
- Induction: 1-1.5 mg/kg.
- Same infusion and light sedation dosing as adults.
Pediatric Patients:
- Induction: 2-3 mg/kg.
- Infusion: Start at 25-100 mcg/kg/min, adjusting similarly.

Contraindications

Hypovolemia and shock.
Hypersensitivity to propofol or its components (e.g., egg phospholipids, soybean oil).
Increased intracranial pressure or impaired cerebral perfusion.
Pregnancy.

Precautions

Risk of hypotension may arise due to vasodilation.
Use with caution in the elderly, debilitated patients, or those with renal/hepatic impairments (consider halving the initial induction dose).

Key Notes

Highly lipid-soluble, making it nearly insoluble in water; administered in a lipid emulsion.
Rapidly crosses the blood-brain barrier and distributes quickly to well-perfused organs.
May cause pain upon administration; pre-treating with lidocaine (0.5-1 mg/kg) can mitigate this.

Administration Details

Route: IV
Onset of action: 1-2 minutes
Peak: Unknown
Duration: 3-5 minutes

Description

This quiz consists of flashcards focused on propofol, a common anesthetic and sedative-hypnotic. Each card provides key information such as trade name, class, supply details, and actions. Perfect for students and professionals looking to reinforce their understanding of this medication.