Podcast
Questions and Answers
Which class of pharmacologic agents is central to the practice of anesthesiology?
Which class of pharmacologic agents is central to the practice of anesthesiology?
- Antidepressants
- Anticoagulants
- Intravenous sedatives and hypnotics (correct)
- Antibiotics
What is the term used for a drug that induces a state of calm or sleep?
What is the term used for a drug that induces a state of calm or sleep?
- Anxiolytic
- Hypnotic
- Antipsychotic
- Sedative (correct)
What is the term used for a drug that induces hypnosis or sleep?
What is the term used for a drug that induces hypnosis or sleep?
- Anxiolytic
- Sedative
- Antipsychotic
- Hypnotic (correct)
Which of the following is a property of propofol?
Which of the following is a property of propofol?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
How does propofol contribute to the suppression of phagocytosis?
How does propofol contribute to the suppression of phagocytosis?
What effect does subhypnotic concentrations of propofol have on pharyngeal contraction force?
What effect does subhypnotic concentrations of propofol have on pharyngeal contraction force?
Which of the following is a potential adverse effect of propofol sedation in children in the ICU?
Which of the following is a potential adverse effect of propofol sedation in children in the ICU?
What laboratory evaluation is recommended when unexpected tachycardia occurs during propofol anesthesia?
What laboratory evaluation is recommended when unexpected tachycardia occurs during propofol anesthesia?
What is the potential mechanism for sporadic propofol-induced metabolic acidosis?
What is the potential mechanism for sporadic propofol-induced metabolic acidosis?
What is the recommended handling technique for propofol to prevent bacterial growth?
What is the recommended handling technique for propofol to prevent bacterial growth?
Which of the following terms refers to a drug that induces a state of calm or sleep?
Which of the following terms refers to a drug that induces a state of calm or sleep?
What is the chemical composition of propofol?
What is the chemical composition of propofol?
Which route of administration is used for propofol?
Which route of administration is used for propofol?
What is the recommended concentration of propofol for intravenous administration?
What is the recommended concentration of propofol for intravenous administration?
What is the primary function of sedative-hypnotics?
What is the primary function of sedative-hypnotics?
Which of the following is NOT a sedative-hypnotic?
Which of the following is NOT a sedative-hypnotic?
Which of the following is a component of the solution used for propofol administration?
Which of the following is a component of the solution used for propofol administration?
What is the term used to describe drugs that reversibly depress the activity of the central nervous system?
What is the term used to describe drugs that reversibly depress the activity of the central nervous system?
Which of the following adverse effects has been observed in children in the ICU with long-term propofol sedation?
Which of the following adverse effects has been observed in children in the ICU with long-term propofol sedation?
What is the potential mechanism for sporadic propofol-induced metabolic acidosis?
What is the potential mechanism for sporadic propofol-induced metabolic acidosis?
What is the recommended laboratory evaluation when unexpected tachycardia occurs during propofol anesthesia?
What is the recommended laboratory evaluation when unexpected tachycardia occurs during propofol anesthesia?
What is the recommended handling technique for propofol to prevent bacterial growth?
What is the recommended handling technique for propofol to prevent bacterial growth?
What is the potential consequence of prolonged propofol infusion for a craniotomy?
What is the potential consequence of prolonged propofol infusion for a craniotomy?
What is the term used for the spontaneous excitatory movements of subcortical origin associated with propofol administration?
What is the term used for the spontaneous excitatory movements of subcortical origin associated with propofol administration?
What is the reported incidence of excitatory movements and associated electrocardiogram changes after propofol administration?
What is the reported incidence of excitatory movements and associated electrocardiogram changes after propofol administration?
What is the term used for the intense dreaming activity, amorous behavior, and hallucinations reported during recovery from low-dose infusions of propofol?
What is the term used for the intense dreaming activity, amorous behavior, and hallucinations reported during recovery from low-dose infusions of propofol?
What is the recommended timeframe for discarding the contents of an opened ampule of propofol if they are not used?
What is the recommended timeframe for discarding the contents of an opened ampule of propofol if they are not used?
What is the recommended timeframe for discarding the tubing and any unused portion of propofol in the ICU?
What is the recommended timeframe for discarding the tubing and any unused portion of propofol in the ICU?
Which of the following is a potential benefit of propofol in disease states such as acute lung injury?
Which of the following is a potential benefit of propofol in disease states such as acute lung injury?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
How can the incidence of pain on propofol injection be decreased?
How can the incidence of pain on propofol injection be decreased?
What is the potential consequence of accidental intra-arterial injection of propofol?
What is the potential consequence of accidental intra-arterial injection of propofol?
How do subhypnotic concentrations of propofol, isoflurane, and sevoflurane affect pharyngeal contraction force?
How do subhypnotic concentrations of propofol, isoflurane, and sevoflurane affect pharyngeal contraction force?
What is the potential mechanism for propofol's neuroprotective effect?
What is the potential mechanism for propofol's neuroprotective effect?
What is the potential benefit of propofol's antioxidant properties in relation to phagocytosis?
What is the potential benefit of propofol's antioxidant properties in relation to phagocytosis?
What is the potential benefit of changing the composition of the carrier fat emulsion for propofol?
What is the potential benefit of changing the composition of the carrier fat emulsion for propofol?
What is the potential consequence of reintroducing molecular oxygen into previously ischemic tissues?
What is the potential consequence of reintroducing molecular oxygen into previously ischemic tissues?
What is the potential consequence of oxygen reacting with polyunsaturated fatty acids of cell membranes?
What is the potential consequence of oxygen reacting with polyunsaturated fatty acids of cell membranes?
Propofol is a sedative-hypnotic drug?
Propofol is a sedative-hypnotic drug?
Propofol is administered intravenously?
Propofol is administered intravenously?
Propofol is chemically distinct from other IV sedative-hypnotics?
Propofol is chemically distinct from other IV sedative-hypnotics?
Propofol can be used to induce general anesthesia?
Propofol can be used to induce general anesthesia?
Propofol is administered as a 1% solution?
Propofol is administered as a 1% solution?
Propofol is administered in a solution containing soybean oil and egg phosphatide?
Propofol is administered in a solution containing soybean oil and egg phosphatide?
Propofol is commonly used for longer than 24 hours?
Propofol is commonly used for longer than 24 hours?
Propofol has a similar dose equivalent to thiopental?
Propofol has a similar dose equivalent to thiopental?
Propofol can be administered at a rate of 75 μg/kg/minute?
Propofol can be administered at a rate of 75 μg/kg/minute?
Propofol is a γ-Aminobutyric Acid Agonist?
Propofol is a γ-Aminobutyric Acid Agonist?
Propofol sedation has been observed to cause severe and fatal bradycardia in children in the ICU.
Propofol sedation has been observed to cause severe and fatal bradycardia in children in the ICU.
Short-term infusions of propofol have been associated with the development of metabolic acidosis.
Short-term infusions of propofol have been associated with the development of metabolic acidosis.
Measurement of arterial blood gases and serum lactate concentrations is recommended when tachycardia occurs during propofol anesthesia.
Measurement of arterial blood gases and serum lactate concentrations is recommended when tachycardia occurs during propofol anesthesia.
Metabolic acidosis caused by propofol administration is reversible with discontinuation of the drug.
Metabolic acidosis caused by propofol administration is reversible with discontinuation of the drug.
Propofol-induced metabolic acidosis is believed to be caused by impaired oxidation of long chain fatty acids.
Propofol-induced metabolic acidosis is believed to be caused by impaired oxidation of long chain fatty acids.
Propofol-induced seizures during anesthesia are thought to be due to cortical epileptic activity.
Propofol-induced seizures during anesthesia are thought to be due to cortical epileptic activity.
Propofol does not produce seizure activity on the EEG when administered to patients with epilepsy.
Propofol does not produce seizure activity on the EEG when administered to patients with epilepsy.
Propofol has been reported to have addictive potential.
Propofol has been reported to have addictive potential.
Propofol strongly supports the growth of Escherichia coli and Pseudomonas aeruginosa.
Propofol strongly supports the growth of Escherichia coli and Pseudomonas aeruginosa.
An aseptic technique should be used when handling propofol to prevent bacterial growth.
An aseptic technique should be used when handling propofol to prevent bacterial growth.
True or false: Propofol can remain sterile at room temperature for several days when drawn into an uncapped syringe?
True or false: Propofol can remain sterile at room temperature for several days when drawn into an uncapped syringe?
True or false: Propofol has antioxidant properties similar to vitamin E?
True or false: Propofol has antioxidant properties similar to vitamin E?
True or false: Propofol's phenol ring structure allows it to inhibit lipid peroxidation by reacting with lipid peroxyl radicals?
True or false: Propofol's phenol ring structure allows it to inhibit lipid peroxidation by reacting with lipid peroxyl radicals?
True or false: Propofol scavenges peroxynitrite, which is a potent bactericidal agent?
True or false: Propofol scavenges peroxynitrite, which is a potent bactericidal agent?
True or false: Propofol's antioxidant potential contributes to its ability to suppress phagocytosis?
True or false: Propofol's antioxidant potential contributes to its ability to suppress phagocytosis?
True or false: Propofol may be beneficial in disease states like acute lung injury?
True or false: Propofol may be beneficial in disease states like acute lung injury?
True or false: Propofol strongly attenuates lipid peroxidation during coronary artery bypass graft surgery?
True or false: Propofol strongly attenuates lipid peroxidation during coronary artery bypass graft surgery?
True or false: Pain on injection is the most commonly reported adverse event associated with propofol administration to awake patients?
True or false: Pain on injection is the most commonly reported adverse event associated with propofol administration to awake patients?
True or false: Preceding propofol with 1% lidocaine or a potent short-acting opioid can decrease the incidence of pain on injection?
True or false: Preceding propofol with 1% lidocaine or a potent short-acting opioid can decrease the incidence of pain on injection?
True or false: Changing the composition of the carrier fat emulsion for propofol can decrease the incidence of pain on injection?
True or false: Changing the composition of the carrier fat emulsion for propofol can decrease the incidence of pain on injection?
Propofol is a type of intravenous sedative-hypnotic drug.
Propofol is a type of intravenous sedative-hypnotic drug.
Sedative refers to a drug that induces hypnosis or sleep.
Sedative refers to a drug that induces hypnosis or sleep.
Propofol is chemically distinct from all other drugs that act as IV sedative-hypnotics.
Propofol is chemically distinct from all other drugs that act as IV sedative-hypnotics.
Propofol is administered intravenously as a 1% solution in soybean oil and egg phosphatide.
Propofol is administered intravenously as a 1% solution in soybean oil and egg phosphatide.
Propofol can be used to induce general anesthesia.
Propofol can be used to induce general anesthesia.
True or false: Long-term propofol sedation in children in the ICU has been associated with severe and fatal bradycardia.
True or false: Long-term propofol sedation in children in the ICU has been associated with severe and fatal bradycardia.
True or false: Short-term infusions of propofol for surgical anesthesia have been linked to the development of metabolic acidosis.
True or false: Short-term infusions of propofol for surgical anesthesia have been linked to the development of metabolic acidosis.
True or false: Propofol-induced metabolic acidosis is reversible with discontinuation of propofol administration.
True or false: Propofol-induced metabolic acidosis is reversible with discontinuation of propofol administration.
True or false: Propofol-induced seizures during induction or emergence from anesthesia are due to cortical epileptic activity.
True or false: Propofol-induced seizures during induction or emergence from anesthesia are due to cortical epileptic activity.
True or false: Propofol strongly supports the growth of Escherichia coli and Pseudomonas aeruginosa.
True or false: Propofol strongly supports the growth of Escherichia coli and Pseudomonas aeruginosa.
True or false: Propofol has antioxidant properties that resemble those of vitamin E?
True or false: Propofol has antioxidant properties that resemble those of vitamin E?
True or false: Propofol reacts with lipid peroxyl radicals and inhibits lipid peroxidation?
True or false: Propofol reacts with lipid peroxyl radicals and inhibits lipid peroxidation?
True or false: Propofol's antioxidant potential is at least partially related to its phenol ring structure?
True or false: Propofol's antioxidant potential is at least partially related to its phenol ring structure?
True or false: Propofol's peroxynitrite-scavenging activity contributes to its ability to suppress phagocytosis?
True or false: Propofol's peroxynitrite-scavenging activity contributes to its ability to suppress phagocytosis?
True or false: Changing the composition of the carrier fat emulsion for propofol decreases the incidence of pain on injection?
True or false: Changing the composition of the carrier fat emulsion for propofol decreases the incidence of pain on injection?
Which of the following terms refers to a drug that induces hypnosis or sleep?
Which of the following terms refers to a drug that induces hypnosis or sleep?
What is the recommended timeframe for discarding the tubing and any unused portion of propofol in the ICU?
What is the recommended timeframe for discarding the tubing and any unused portion of propofol in the ICU?
True or false: Preceding propofol with 1% lidocaine or a potent short-acting opioid can decrease the incidence of pain on injection?
True or false: Preceding propofol with 1% lidocaine or a potent short-acting opioid can decrease the incidence of pain on injection?
What is the term used for the intense dreaming activity, amorous behavior, and hallucinations reported during recovery from low-dose infusions of propofol?
What is the term used for the intense dreaming activity, amorous behavior, and hallucinations reported during recovery from low-dose infusions of propofol?
What is the potential benefit of changing the composition of the carrier fat emulsion for propofol?
What is the potential benefit of changing the composition of the carrier fat emulsion for propofol?
What adverse effect has been associated with short-term infusions of propofol for surgical anesthesia?
What adverse effect has been associated with short-term infusions of propofol for surgical anesthesia?
What laboratory evaluation is recommended when unexpected tachycardia occurs during propofol anesthesia?
What laboratory evaluation is recommended when unexpected tachycardia occurs during propofol anesthesia?
What is the potential mechanism for propofol-induced metabolic acidosis?
What is the potential mechanism for propofol-induced metabolic acidosis?
What is the differential diagnosis when propofol-induced lactic acidosis is suspected?
What is the differential diagnosis when propofol-induced lactic acidosis is suspected?
What is the recommended timeframe for discarding the contents of an opened ampule of propofol if they are not used?
What is the recommended timeframe for discarding the contents of an opened ampule of propofol if they are not used?
Which of the following is a potential benefit of propofol's antioxidant properties?
Which of the following is a potential benefit of propofol's antioxidant properties?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
What is the most commonly reported adverse event associated with propofol administration to awake patients?
What is the effect of subhypnotic concentrations of propofol, isoflurane, and sevoflurane on pharyngeal function?
What is the effect of subhypnotic concentrations of propofol, isoflurane, and sevoflurane on pharyngeal function?
What is the reported incidence of thrombosis or phlebitis associated with propofol administration?
What is the reported incidence of thrombosis or phlebitis associated with propofol administration?
What is the effect of changing the composition of the carrier fat emulsion for propofol?
What is the effect of changing the composition of the carrier fat emulsion for propofol?
Which term refers to a drug that induces hypnosis or sleep?
Which term refers to a drug that induces hypnosis or sleep?
What is the chemical composition of propofol?
What is the chemical composition of propofol?
What is the recommended dose of propofol for rapid IV injection?
What is the recommended dose of propofol for rapid IV injection?
Which of the following is NOT a component of the aqueous solution of propofol?
Which of the following is NOT a component of the aqueous solution of propofol?
What is the term used to describe drugs that reduce anxiety?
What is the term used to describe drugs that reduce anxiety?
What is the primary function of sedative-hypnotics?
What is the primary function of sedative-hypnotics?
Which of the following adverse events has been associated with long-term propofol sedation in children in the ICU?
Which of the following adverse events has been associated with long-term propofol sedation in children in the ICU?
What is the recommended laboratory evaluation when unexpected tachycardia occurs during propofol anesthesia?
What is the recommended laboratory evaluation when unexpected tachycardia occurs during propofol anesthesia?
What is the potential mechanism for propofol-induced metabolic acidosis?
What is the potential mechanism for propofol-induced metabolic acidosis?
Which of the following is a potential consequence of prolonged propofol infusion for a craniotomy?
Which of the following is a potential consequence of prolonged propofol infusion for a craniotomy?
Which of the following is a reported adverse event during recovery from low-dose infusions of propofol?
Which of the following is a reported adverse event during recovery from low-dose infusions of propofol?
What is the recommended handling technique for propofol to prevent bacterial growth?
What is the recommended handling technique for propofol to prevent bacterial growth?
Which of the following is a potential consequence of oxygen reacting with polyunsaturated fatty acids of cell membranes?
Which of the following is a potential consequence of oxygen reacting with polyunsaturated fatty acids of cell membranes?
True or false: Short-term infusions of propofol for surgical anesthesia have been linked to the development of metabolic acidosis.
True or false: Short-term infusions of propofol for surgical anesthesia have been linked to the development of metabolic acidosis.
What is the recommended handling technique for propofol to prevent bacterial growth?
What is the recommended handling technique for propofol to prevent bacterial growth?
True or false: Propofol's antioxidant potential contributes to its ability to suppress phagocytosis?
True or false: Propofol's antioxidant potential contributes to its ability to suppress phagocytosis?
Which route of administration is used for propofol?
Which route of administration is used for propofol?
True or false: Pain on injection is the most commonly reported adverse event associated with propofol administration to awake patients?
True or false: Pain on injection is the most commonly reported adverse event associated with propofol administration to awake patients?
True or false: Propofol may be beneficial in disease states like acute lung injury?
True or false: Propofol may be beneficial in disease states like acute lung injury?
What is the effect of changing the composition of the carrier fat emulsion for propofol?
What is the effect of changing the composition of the carrier fat emulsion for propofol?
Study Notes
Anesthesiology and Propofol
- Anesthesiology is closely related to sedative-hypnotic drugs, which induce a state of calm or sleep.
- Propofol is a sedative-hypnotic drug commonly used in anesthesiology.
Propofol Characteristics
- Propofol is a type of intravenous sedative-hypnotic drug.
- It is chemically distinct from other IV sedative-hypnotics.
- Propofol is administered intravenously as a 1% solution in soybean oil and egg phosphatide.
- It can be used to induce general anesthesia.
Adverse Effects and Contraindications
- Pain on injection is the most commonly reported adverse event associated with propofol administration to awake patients.
- Long-term propofol sedation in children in the ICU has been associated with severe and fatal bradycardia.
- Short-term infusions of propofol for surgical anesthesia have been linked to the development of metabolic acidosis.
- Propofol-induced metabolic acidosis is reversible with discontinuation of propofol administration.
Pharmacology and Mechanisms
- Propofol has antioxidant properties similar to vitamin E.
- Its phenol ring structure allows it to inhibit lipid peroxidation by reacting with lipid peroxyl radicals.
- Propofol scavenges peroxynitrite, which is a potent bactericidal agent.
- Propofol's antioxidant potential contributes to its ability to suppress phagocytosis.
Handling and Storage
- Propofol can support the growth of Escherichia coli and Pseudomonas aeruginosa.
- An aseptic technique should be used when handling propofol to prevent bacterial growth.
- Discard the contents of an opened ampule of propofol if not used within a recommended timeframe.
- Discard the tubing and any unused portion of propofol in the ICU within a recommended timeframe.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on IV sedatives and hypnotics in anesthesiology with this quiz! From anxiolysis to general anesthesia, this class of drugs plays a crucial role in the practice. Challenge yourself and learn more about their uses, effects, and administration.
